5ODM
 
 | | NtiPr polyamide in complex with 5'CGATGTACTACG3 | | 分子名称: | 3-(3-azaniumylpropanoylamino)propyl-dimethyl-azanium, 4-AMINO-(1-METHYLIMIDAZOLE)-2-CARBOXYLIC ACID, 4-AMINO-(1-METHYLPYRROLE)-2-CARBOXYLIC ACID, ... | | 著者 | Padroni, G, Parkinson, J, Burley, G.A. | | 登録日 | 2017-07-06 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides.
Nucleic Acids Res., 46, 2018
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4FIA
 | | Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound | | 分子名称: | Cholesterol 24-hydroxylase, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Stout, C.D, Pikuleva, I.A, Mast, N. | | 登録日 | 2012-06-08 | | 公開日 | 2013-01-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
J.Biol.Chem., 288, 2013
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5OE2
 | | CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245 | | 分子名称: | Beta-lactamase, CHLORIDE ION, SODIUM ION | | 著者 | Lund, B.A, Leiros, H.K.S. | | 登録日 | 2017-07-07 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis.
Acta Crystallogr F Struct Biol Commun, 73, 2017
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6WVD
 | | Human JAGN1 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Green fluorescent protein, Protein jagunal homolog 1 chimera | | 著者 | Yang, Y, Liu, S, Li, W. | | 登録日 | 2020-05-05 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Termini restraining of small membrane proteins enables structure determination at near-atomic resolution.
Sci Adv, 6, 2020
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4OZU
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4O74
 | | Crystal structure of the first bromodomain of human BRD4 in complex with BI 2536 | | 分子名称: | 1,2-ETHANEDIOL, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 4, ... | | 著者 | Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. | | 登録日 | 2013-12-24 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
Acs Chem.Biol., 9, 2014
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3UU0
 | | Crystal structure of L-rhamnose isomerase from Bacillus halodurans in complex with Mn | | 分子名称: | L-rhamnose isomerase, MANGANESE (II) ION | | 著者 | Doan, T.T.N, Prabhu, P, Kim, J.K, Jeya, M, Kang, L.W, Lee, J.K. | | 登録日 | 2011-11-27 | | 公開日 | 2012-02-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure-based studies on the metal binding of two-metal-dependent sugar isomerases.
Febs J., 281, 2014
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2Y3J
 | | Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35) | | 分子名称: | AMYLOID BETA A4 PROTEIN | | 著者 | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | 登録日 | 2010-12-21 | | 公開日 | 2011-11-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4YYM
 | | Crystal structure of TAF1 BD2 Bromodomain bound to a butyryllysine peptide | | 分子名称: | CALCIUM ION, Histone H4, Transcription initiation factor TFIID subunit 1 | | 著者 | Tang, Y, Bellon, S, Cochran, A.G, Poy, F. | | 登録日 | 2015-03-24 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
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3UVA
 | | Crystal structure of L-rhamnose isomerase mutant W38F from Bacillus halodurans in complex with Mn | | 分子名称: | L-Rhamnose isomerase, MANGANESE (II) ION | | 著者 | Doan, T.T.N, Prabhu, P, Jeya, M, Kim, J.K, Kang, L.W, Lee, J.K. | | 登録日 | 2011-11-29 | | 公開日 | 2012-12-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Structure-based studies on the metal binding of two-metal-dependent sugar isomerases.
Febs J., 281, 2014
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4O7E
 | | Crystal structure of the first bromodomain of human BRD4 in complex with SB-610251-B | | 分子名称: | 1,2-ETHANEDIOL, 3-[2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl]phenol, Bromodomain-containing protein 4 | | 著者 | Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. | | 登録日 | 2013-12-24 | | 公開日 | 2014-03-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
Acs Chem.Biol., 9, 2014
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4YYT
 | | Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (5). | | 分子名称: | 4-(2-hydroxyethyl)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... | | 著者 | Rechlin, C, Heine, A, Klebe, G. | | 登録日 | 2015-03-24 | | 公開日 | 2016-02-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | | 主引用文献 | Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.
J.Med.Chem., 59, 2016
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6WZ2
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5OGX
 | | Crystal structure of Amycolatopsis cytochrome P450 reductase GcoB. | | 分子名称: | BROMIDE ION, Cytochrome P450 reductase, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Mallinson, S.J.B, Johnson, C.W, Neidle, E.L, Beckham, G.T, McGeehan, J.E. | | 登録日 | 2017-07-13 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion.
Nat Commun, 9, 2018
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2XJZ
 | | Crystal structure of the LMO2:LDB1-LID complex, C2 crystal form | | 分子名称: | CHLORIDE ION, LIM DOMAIN-BINDING PROTEIN 1, RHOMBOTIN-2, ... | | 著者 | El Omari, K, Karia, D, Porcher, C, Mancini, E.J. | | 登録日 | 2010-07-06 | | 公開日 | 2010-07-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of the Leukemia Oncogene Lmo2: Implications for the Assembly of a Hematopoietic Transcription Factor Complex.
Blood, 117, 2011
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4YZP
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3UVX
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K12acK16ac) | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, FORMIC ACID, ... | | 著者 | Filippakopoulos, P, Picaud, S, Keates, T, Ugochukwu, E, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2011-11-30 | | 公開日 | 2012-01-25 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
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2XGY
 | | Complex of Rabbit Endogenous Lentivirus (RELIK)Capsid with Cyclophilin A | | 分子名称: | GLYCEROL, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, RELIK CAPSID N-TERMINAL DOMAIN | | 著者 | Goldstone, D.C, Robertson, L.E, Haire, L.F, Stoye, J.P, Taylor, I.A. | | 登録日 | 2010-06-08 | | 公開日 | 2010-09-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and Functional Analysis of Prehistoric Lentiviruses Uncovers an Ancient Molecular Interface.
Cell Host Microbe, 8, 2010
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6WZ7
 | | Mn-bound structure of a TriCyt3 variant | | 分子名称: | CALCIUM ION, CHLORIDE ION, HEME C, ... | | 著者 | Tezcan, F.A, Kakkis, A. | | 登録日 | 2020-05-13 | | 公開日 | 2020-09-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Metal-Templated Design of Chemically Switchable Protein Assemblies with High-Affinity Coordination Sites.
Angew.Chem.Int.Ed.Engl., 59, 2020
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2XVH
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5OKI
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5AK4
 | | ligand complex structure of soluble epoxide hydrolase | | 分子名称: | 3-METHYL-4-PHENYL-1H-PYRAZOLE, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE | | 著者 | Oster, L, Tapani, S, Xue, Y, Kack, H. | | 登録日 | 2015-03-02 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Successful Generation of Structural Information for Fragment-Based Drug Discovery.
Drug Discov Today, 20, 2015
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2XUE
 | | CRYSTAL STRUCTURE OF JMJD3 | | 分子名称: | 2-OXOGLUTARIC ACID, FE (III) ION, LYSINE-SPECIFIC DEMETHYLASE 6B, ... | | 著者 | Chung, C, Rowland, P, Mosley, J, Thomas, P.J. | | 登録日 | 2010-10-19 | | 公開日 | 2011-12-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response
Nature, 488, 2012
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2Y2A
 | | Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I | | 分子名称: | ACETATE ION, AMYLOID BETA A4 PROTEIN | | 著者 | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | | 登録日 | 2010-12-14 | | 公開日 | 2011-10-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Molecular Basis for Amyloid-{Beta} Polymorphism.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2XDV
 | | Crystal Structure of the Catalytic Domain of FLJ14393 | | 分子名称: | 1,2-ETHANEDIOL, CADMIUM ION, MANGANESE (II) ION, ... | | 著者 | Krojer, T, Muniz, J.R.C, Ng, S.S, Pilka, E, Guo, K, Pike, A.C.W, Filippakopoulos, P, Knapp, S, Kavanagh, K.L, Gileadi, O, Bunkoczi, G, Yue, W.W, Niesen, F, Sobott, F, Fedorov, O, Savitsky, P, Kochan, G, Daniel, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Oppermann, U. | | 登録日 | 2010-05-07 | | 公開日 | 2010-05-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
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