PDB: 37224 件ウェブページステータス検索Chemie searchBIRD

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6XX2	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Cu(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin 分子名称: COPPER (II) ION, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, Proto-oncogene tyrosine-protein kinase Src 著者 Camara-Artigas, A. 登録日 2020-01-26 公開日 2020-04-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6MX9	Lysozyme bound to 3-Aminophenol 分子名称: 1,2-ETHANEDIOL, 3-aminophenol, BENZAMIDINE, ... 著者 Blackburn, A, Partowmah, S.H, Brennan, H.M, Mestizo, K.E, Stivala, C.D, Petreczky, J, Perez, A, Horn, A, McSweeney, S. 登録日 2018-10-30 公開日 2018-12-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A simple technique to improve microcrystals using gel exclusion of nucleation inducing elements To Be Published
6XX7	Arabidopsis thaliana Casein Kinase 2 (CK2) alpha-1 crystal in complex with ANP 分子名称: CHLORIDE ION, Casein kinase II subunit alpha-1, MAGNESIUM ION, ... 著者 Demulder, M, De Veylder, L, Loris, R. 登録日 2020-01-27 公開日 2020-04-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of Arabidopsis thaliana casein kinase 2 alpha 1. Acta Crystallogr.,Sect.F, 76, 2020
6N6Q	Crystal structure of a Cytochrome P450 (CYP102L1) 分子名称: CACODYLATE ION, Cytochrome P450 (CYP102L1), PROTOPORPHYRIN IX CONTAINING FE 著者 Follmer, A.H, Poulos, T.L. 登録日 2018-11-26 公開日 2019-06-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 On the occurrence of cytochrome P450 in viruses. Proc.Natl.Acad.Sci.USA, 116, 2019
5YEF	Crystal structure of CTCF ZFs2-8-Hs5-1aE 分子名称: DNA (27-MER), Transcriptional repressor CTCF, ZINC ION 著者 Yin, M, Wang, J, Wang, M, Li, X, Wang, Y. 登録日 2017-09-17 公開日 2017-11-29 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.807 Å) 主引用文献 Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites Cell Res., 27, 2017
5YF9	Crystal structure of CK2a2 form-2 分子名称: Casein kinase II subunit alpha', NICOTINIC ACID, SULFATE ION 著者 Tsuyuguchi, M, Kinoshita, T. 登録日 2017-09-20 公開日 2018-05-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal structures of human CK2 alpha 2 in new crystal forms arising from a subtle difference in salt concentration Acta Crystallogr F Struct Biol Commun, 74, 2018
6N02	CO-bound Sperm Whale Myoglobin, room temperature structure, first 2 degrees of 5 degree total oscillation 分子名称: CARBON MONOXIDE, Myoglobin, CO-bound, ... 著者 Finke, A.D, Wierman, J.L, Pare-Labrosse, O, Sarrachini, A, Besaw, J, Mehrabi, P, Gruner, S.M, Miller, R.J.D. 登録日 2018-11-06 公開日 2019-03-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fixed-target serial oscillation crystallography at room temperature. IUCrJ, 6, 2019
6XVR	Human myelin protein P2 mutant L35S 分子名称: Myelin P2 protein, PALMITIC ACID, SULFATE ION 著者 Ruskamo, S, Lehtimaki, M, Kursula, P. 登録日 2020-01-22 公開日 2020-04-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice. J.Biol.Chem., 295, 2020
8EML	Crystal Structure of Gsx2 Homeodomain in Complex with DNA 分子名称: DNA (5'-D(P*GP*AP*GP*CP*TP*AP*AP*TP*TP*AP*AP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*TP*TP*AP*AP*TP*TP*AP*GP*CP*TP*C)-3'), GS homeobox 2, ... 著者 Webb, J.A, Kovall, R.A. 登録日 2022-09-28 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal Structure of Gsx2 Homeodomain in Complex with DNA To Be Published
5YJ9	Crystal structure of Tribolium castaneum PINK1 kinase domain in complex with AMP-PNP 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase PINK1, ... 著者 Okatsu, K, Sato, Y, Fukai, S. 登録日 2017-10-09 公開日 2018-07-25 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Structural insights into ubiquitin phosphorylation by PINK1. Sci Rep, 8, 2018
8YA1	HEN EGG WHITE LYSOZYME 分子名称: Lysozyme C 著者 Zhang, C.Y, Xu, Q, Wang, W.W, Zhou, H. 登録日 2024-02-07 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Crystallographic data collection using a multilayer monochromator on an undulator beamline at SSRF To Be Published
8YBG	Crystal structure of lysozyme by serial synchrotron crystallography 分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION 著者 Nam, K.H. 登録日 2024-02-14 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of lysozyme by serial synchrotron crystallography To Be Published
5YJM	Human chymase in complex with 7-oxo-3-(phenoxyimino)-1,4-diazepane derivative 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-4-((R)-1-((R,Z)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carboxamido)propyl)benzoic acid, ZINC ION, ... 著者 Sugawara, H. 登録日 2017-10-11 公開日 2017-12-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors Bioorg. Med. Chem. Lett., 28, 2018
6N3N	Identification of novel, potent and selective GCN2 inhibitors as first-in-class anti-tumor agents 分子名称: N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide, eIF-2-alpha kinase GCN2,eIF-2-alpha kinase GCN2 著者 Hoffman, I.D, Fujimoto, J, Kurasawa, O, Takagi, T, Klein, M.G, Kefala, G, Ding, S.C, Cary, D.R, Mizojiri, R. 登録日 2018-11-15 公開日 2019-10-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.01 Å) 主引用文献 Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode. Acs Med.Chem.Lett., 10, 2019
8ENJ	Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK) 分子名称: Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide 著者 Park, H, Mersal, K.I. 登録日 2022-09-30 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells. Eur.J.Med.Chem., 261, 2023
5YID	Crystal Structure of KNI-10395 bound Plasmepsin II (PMII) from Plasmodium falciparum 分子名称: (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-{[S-methyl-N-(phenylacetyl)-L-cysteinyl]amino}-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Plasmepsin II, ... 著者 Mishra, V, Rathore, I, Bhaumik, P. 登録日 2017-10-04 公開日 2018-07-11 最終更新日 2019-05-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights. Febs J., 285, 2018
6N48	Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator 分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ... 著者 Liu, X, Masoudi, A, Kahsai, A.W, Huang, L.Y, Pani, B, Hirata, K, Ahn, S, Lefkowitz, R.J, Kobilka, B.K. 登録日 2018-11-17 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. Science, 364, 2019
5YKW	Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems 分子名称: Thioredoxin-3, mitochondrial, peptide THR-PRO-VAL-CYS-THR-THR-GLU-VAL 著者 Li, C.C, Yang, J, Yang, M.J, Liu, L, Peng, C.T, Li, T, He, L.H, Song, Y.J, Zhu, Y.B, Zhao, N.L, Zhao, C, Bao, R. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2019-11-06 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems to be published
8ERN	Cyclin-free CDK2 in complex with Cpd21 分子名称: Cyclin-dependent kinase 2, GLYCEROL, N,3-dimethyl-4-({7-[(2S)-2-methylpyrrolidine-1-carbonyl]quinazolin-2-yl}amino)benzene-1-sulfonamide 著者 Murray, J.M, Oh, A. 登録日 2022-10-12 公開日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Cyclin-free CDK2 in complex with Cpd21 To Be Published
8YA4	Crystal structure of a lysozyme form hen egg white 分子名称: Lysozyme C 著者 Zhang, C.Y, Xu, Q, Wang, W.W, Zhou, H. 登録日 2024-02-07 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystallographic data collection using a multilayer monochromator on an undulator beamline at SSRF To Be Published
8OIL	Plasmodium falciparum circumsporozoite protein C-terminal domain 分子名称: Circumsporozoite protein 著者 Sterckx, Y.G.-J, Volkov, A.N, Geens, R. 登録日 2023-03-23 公開日 2024-02-28 最終更新日 2024-10-09 実験手法 SOLUTION NMR, SOLUTION SCATTERING 主引用文献 Plasmodium falciparum circumsporozoite protein C-terminal domain To Be Published
6MQG	Crystal structure of KRAS V14I-GDP demonstrating open switch 1 conformation - Form 1 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE 著者 Bera, A.K, Westover, K.D. 登録日 2018-10-09 公開日 2019-07-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural basis of the atypical activation mechanism of KRASV14I. J.Biol.Chem., 294, 2019
8YBH	Crystal structure of lysozyme by macromolecular crystallography 分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION 著者 Nam, K.H. 登録日 2024-02-14 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of lysozyme by macromolecular crystallography To Be Published
8Y9W	CRYSTAL STRUCTURE OF A LYSOZYME FROM HEN EGG WHITE 分子名称: Lysozyme C 著者 Zhang, C.Y, Xu, Q, Zhou, H, Wang, Q.S. 登録日 2024-02-07 公開日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic data collection using a multilayer monochromator on an undulator beamline at SSRF To Be Published
8OZ3	Crystal structure of scFv ATOR 1017 bound to human 4-1BB 分子名称: Single chain Fv, Tumor necrosis factor receptor superfamily member 9 著者 Hakansson, M, Von Schantz, L, Rose, N. 登録日 2023-05-08 公開日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1. Cancer Immunol.Immunother., 72, 2023

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