8SVA
| Structure of the Rhodococcus sp. USK13 DarR-20 bp DNA complex | 分子名称: | DNA (5'-D(*TP*AP*GP*AP*TP*AP*CP*TP*CP*CP*GP*GP*AP*GP*TP*AP*TP*CP*TP*A)-3'), PHOSPHATE ION, TetR/AcrR family transcriptional regulator | 著者 | Schumacher, M.A. | 登録日 | 2023-05-15 | 公開日 | 2023-11-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Structures of the DarR transcription regulator reveal unique modes of second messenger and DNA binding. Nat Commun, 14, 2023
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8SUA
| Structure of M. baixiangningiae DarR-ligand complex | 分子名称: | 3-azanyl-3-(hydroxymethyl)-1,5,7,11-tetraoxa-6$l^{4}-boraspiro[5.5]undecan-9-ol, DarR | 著者 | Schumacher, M.A. | 登録日 | 2023-05-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structures of the DarR transcription regulator reveal unique modes of second messenger and DNA binding. Nat Commun, 14, 2023
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8SVD
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8SLZ
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8T3P
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8T1B
| Cryo-EM structure of full-length human TRPV4 in apo state | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera, ... | 著者 | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1D
| Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD | 分子名称: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1F
| Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1C
| Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4-Enhanced green fluorescent protein chimera | 著者 | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1E
| Closed-state cryo-EM structure of full-length human TRPV4 in the presence of 4a-PDD | 分子名称: | (2R)-2-{[(4-O-hexopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-4-{[(25R)-5beta,14beta,17beta-spirostan-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, SODIUM ION, Transient receptor potential cation channel subfamily V member 4,Enhanced green fluorescent protein, ... | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T2U
| Cryo-EM Structures of Full-length Integrin alphaIIbbeta3 in Native Lipids complexed with Eptifibatide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Adair, B, Xiong, J.P, Yeager, M, Arnaout, M.A. | 登録日 | 2023-06-06 | 公開日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of full-length integrin alpha IIb beta 3 in native lipids. Nat Commun, 14, 2023
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7SQ4
| Designed trefoil knot protein, variant 2 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Designed trefoil knot protein, variant 2, ... | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | 登録日 | 2021-11-04 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.493 Å) | 主引用文献 | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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7SQ3
| Designed trefoil knot protein, variant 1 | 分子名称: | CHLORIDE ION, Designed trefoil knot protein, variant 1, ... | 著者 | Takushi, B, Doyle, L, Stoddard, B.L, Bradley, P. | 登録日 | 2021-11-04 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.453 Å) | 主引用文献 | De novo design of knotted tandem repeat proteins. Nat Commun, 14, 2023
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2NRY
| Crystal structure of IRAK-4 | 分子名称: | STAUROSPORINE, interleukin-1 receptor-associated kinase 4 | 著者 | Wang, Z, Liu, J, Walker, N.P.C. | 登録日 | 2006-11-02 | 公開日 | 2006-12-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper. Structure, 14, 2006
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7SJS
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8T1P
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8SZC
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8T3K
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7SU1
| Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Fab heavy chain, ... | 著者 | Lee, P.S, Chau, B, Strop, P. | 登録日 | 2021-11-15 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Improved therapeutic index of an acidic pH-selective antibody. Mabs, 14, 2022
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8QME
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2OBD
| Crystal Structure of Cholesteryl Ester Transfer Protein | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Qiu, X. | 登録日 | 2006-12-18 | 公開日 | 2007-01-23 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat.Struct.Mol.Biol., 14, 2007
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8T7E
| Cryo-EM structure of the Backtracking Initiation Complex (VII) of Human Mitochondrial DNA Polymerase Gamma | 分子名称: | DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-2, mitochondrial, ... | 著者 | Nayak, A.R, Buchel, G, Herbine, K.H, Sarfallah, A, Sokolova, V.O, Zamudio-Ochoa, A, Temiakov, D. | 登録日 | 2023-06-20 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis for DNA proofreading. Nat Commun, 14, 2023
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2OKK
| The X-ray crystal structure of the 65kDa isoform of Glutamic Acid Decarboxylase (GAD65) | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, GLYCEROL, Glutamate decarboxylase 2 | 著者 | Buckle, A.M, Fenalti, G, Law, R.H.P, Whisstock, J.C. | 登録日 | 2007-01-17 | 公開日 | 2007-03-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat.Struct.Mol.Biol., 14, 2007
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2NRU
| Crystal structure of IRAK-4 | 分子名称: | 1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)AMINO]-1H-BENZIMIDAZOL-5-YL PIVALATE, Interleukin-1 receptor-associated kinase 4, SULFATE ION | 著者 | Wang, Z, Liu, J, Walker, N.P.C. | 登録日 | 2006-11-02 | 公開日 | 2006-12-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper. Structure, 14, 2006
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8RP4
| Alpha-Methylacyl-CoA racemase from Mycobacterium tuberculosis (D156A mutant) | 分子名称: | 1,2-ETHANEDIOL, Alpha-methylacyl-CoA racemase, DI(HYDROXYETHYL)ETHER | 著者 | Mojanaga, O.O, Acharya, K.R, Lloyd, M.D. | 登録日 | 2024-01-12 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | alpha-Methylacyl-CoA Racemase from Mycobacterium tuberculosis -Detailed Kinetic and Structural Characterization of the Active Site. Biomolecules, 14, 2024
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