PDB: 236060 件ウェブページステータス検索Chemie searchBIRD

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7MT8	Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin 分子名称: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ... 著者 Chen, Q, Chen, C.-L, Tesmer, J.J.G. 登録日 2021-05-13 公開日 2021-07-07 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1. Nature, 595, 2021
6Q8P	Structure of CLK1 with bound N-methyl-10-nitropyrido[3,4-g]quinazolin-2-amine 分子名称: Dual specificity protein kinase CLK1, POTASSIUM ION, ~{N}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine 著者 Joerger, A.C, Chatterjee, D, Schroeder, M, Tazarki, H, Zeinyeh, W, Esvan, Y.J, Khiari, J, Josselin, B, Baratte, B, Bach, S, Ruchaud, S, Anizon, F, Giraud, F, Moreau, P, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2018-12-15 公開日 2019-02-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur J Med Chem, 166, 2019
1FKM	CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P 分子名称: PROTEIN (GYP1P) 著者 Rak, A, Fedorov, R, Alexandrov, K, Albert, S, Goody, R.S, Gallwitz, D, Scheidig, A.J. 登録日 2000-08-09 公開日 2001-02-09 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins. EMBO J., 19, 2000
7YO2	Cryo-EM structure of RCK1-RCK2 mutated human Slo1 apo 分子名称: Calcium-activated potassium channel subunit alpha-1 著者 Yamanouchi, D, Nureki, O. 登録日 2022-08-01 公開日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex To Be Published
5I21	Y55W Hfq from Pseudomonas aeruginosa 分子名称: CHLORIDE ION, RNA-binding protein Hfq 著者 Nikulin, A.D, Lekontseva, N.V. 登録日 2016-02-08 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Y55W Hfq from Pseudomonas aeruginosa To Be Published
6YM5	Crystal structure of BAY-091 with PIP4K2A 分子名称: (2~{R})-2-[[3-cyano-2-[4-(2-fluoranyl-3-methyl-phenyl)phenyl]-1,7-naphthyridin-4-yl]amino]butanoic acid, PHOSPHATE ION, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 著者 Holton, S.J, Wortmann, L, Braeuer, N, Irlbacher, H, Weiske, J, Lechner, C, Meier, R, Puetter, V, Christ, C, ter Laak, T, Lienau, P, Lesche, R, Nicke, B, Bauser, M, Haegebarth, A, von Nussbaum, F, Mumberg, D, Lemos, C. 登録日 2020-04-07 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64, 2021
3I9P	Crystal structure of human transthyretin - wild type 分子名称: Transthyretin 著者 Lima, L.M.T.R, Foguel, D. 登録日 2009-07-12 公開日 2009-10-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of human transthyretin - wild type To be Published
6WYQ	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with 4-iodo-SAHA 分子名称: Histone deacetylase 6, N~1~-hydroxy-N~8~-(4-iodophenyl)octanediamide, POTASSIUM ION, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2020-05-13 公開日 2020-09-02 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.90001464 Å) 主引用文献 Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallogr.,Sect.F, 76, 2020
8RF7	Crystal structure of maize adenosine kinase 2 (ADK2) apoform 分子名称: ACETATE ION, Adenosine kinase, GLYCEROL, ... 著者 Morera, S, Kopecny, D, Vigouroux, A. 登録日 2023-12-12 公開日 2025-01-01 最終更新日 2025-04-09 実験手法 X-RAY DIFFRACTION (2.051 Å) 主引用文献 A monomer-dimer switch modulates the activity of plant adenosine kinase. J.Exp.Bot., 2025
4QGM	Acireductone dioxygenase from Bacillus anthracis with cadmium ion in active center 分子名称: Acireductone dioxygenase, CADMIUM ION 著者 Milaczewska, A.M, Chruszcz, M, Shabalin, I.G, Cooper, D.R, Borowski, T, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2014-05-23 公開日 2014-06-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Acireductone dioxygenase from Bacillus anthracis with cadmium ion in active center To be Published
1C26	CRYSTAL STRUCTURE OF P53 TETRAMERIZATION DOMAIN 分子名称: P53 TUMOR SUPPRESSOR 著者 Jeffrey, P.D, Gorina, S, Pavletich, N.P. 登録日 1999-07-22 公開日 1999-07-27 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science, 267, 1995
6MQG	Crystal structure of KRAS V14I-GDP demonstrating open switch 1 conformation - Form 1 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE 著者 Bera, A.K, Westover, K.D. 登録日 2018-10-09 公開日 2019-07-31 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural basis of the atypical activation mechanism of KRASV14I. J.Biol.Chem., 294, 2019
6TRO	Crystal structure of the T-cell receptor GVY01 bound to HLA A2*01-GVYDGREHTV 分子名称: Beta-2-microglobulin, MAGE-A4 peptide (amino acids 230-239), MHC class I antigen, ... 著者 Coles, C.H, McMurran, C, Lloyd, A, Hibbert, L, Lupardus, P.J, Cole, D.K, Harper, S. 登録日 2019-12-19 公開日 2020-06-24 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4. J.Biol.Chem., 295, 2020
6QLT	Galectin-3C in complex with fluoroaryltriazole monothiogalactoside derivative-7 分子名称: (2~{R},3~{R},4~{S},5~{R},6~{S})-4-[4-(2-fluorophenyl)-1,2,3-triazol-1-yl]-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyl-oxane-3,5-diol, DI(HYDROXYETHYL)ETHER, Galectin-3 著者 Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T. 登録日 2019-02-01 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structure and Energetics of Ligand-Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides: Insight into Solvation Effects and Multipolar Interactions. Chemmedchem, 14, 2019
1FC8	NMR SOLUTION STRUCTURE OF A CHIMERIC OLIGONUCLEOTIDE HAIRPIN R(GGAC)D(TTCG)2'F-A(GTCC) 分子名称: 5'-R(*GP*GP*AP*CP)D(*TP*TP*CP*GP*(GFL)P*(TAF)P*(CFL)P*(CFL))-3' 著者 Trempe, J.-F, Gehring, K. 登録日 2000-07-18 公開日 2001-05-30 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of an oligonucleotide hairpin with a 2'F-ANA/RNA stem: implications for RNase H specificity toward DNA/RNA hybrid duplexes. J.Am.Chem.Soc., 123, 2001
5LA8	Room temperature X-ray diffraction of tetragonal HEWL. Third data set (0.93 MGy) 分子名称: ACETATE ION, CHLORIDE ION, Lysozyme C 著者 Castellvi, A, Juanhuix, J. 登録日 2016-06-13 公開日 2016-12-21 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Uridine as a new scavenger for synchrotron-based structural biology techniques. J Synchrotron Radiat, 24, 2017
6QGG	Structure of human Bcl-2 in complex with analogue of ABT-737 分子名称: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, [(3~{R})-3-[[4-[[4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]phenyl]carbonylsulfamoyl]-2-nitro-phenyl]amino]-4-phenylsulfanyl-butyl]-(2-hydroxy-2-oxoethyl)-dimethyl-azanium 著者 Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. 登録日 2019-01-11 公開日 2019-06-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4, 2019
7UGG	Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Dyclonine, SODIUM ION, ... 著者 Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. 登録日 2022-03-24 公開日 2022-06-08 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine. Nat Commun, 13, 2022
6YRZ	Crystal structure of FAP et pH 8.5 after illumination at 150K 分子名称: CARBON DIOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, Fatty acid photodecarboxylase, ... 著者 Sorigue, D, Legrand, P, Blangy, S, Beisson, F, Arnoux, P. 登録日 2020-04-20 公開日 2021-04-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.824 Å) 主引用文献 Mechanism and dynamics of fatty acid photodecarboxylase. Science, 372, 2021
6TQB	X-ray structure of Roquin ROQ domain in complex with a UCP3 CDE1 SL RNA motif 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... 著者 Binas, O, Tants, J.-N, Peter, S.A, Janowski, R, Davydova, E, Braun, J, Niessing, D, Schwalbe, H, Weigand, J.E, Schlundt, A. 登録日 2019-12-16 公開日 2020-05-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural basis for the recognition of transiently structured AU-rich elements by Roquin. Nucleic Acids Res., 48, 2020
6WKE	Crystal structure of pentalenene synthase mutant F76Y 分子名称: GLYCEROL, Pentalenene synthase 著者 Prem Kumar, R, Matos, J.O, Oprian, D.D. 登録日 2020-04-16 公開日 2020-08-26 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase. Biochemistry, 59, 2020
6YM3	Crystal structure of Compound 1 with PIP4K2A 分子名称: (2~{R})-2-[[3-cyano-2-[4-(2-ethoxyphenyl)phenyl]-5,8-dihydro-1,7-naphthyridin-4-yl]amino]propanoic acid, PHOSPHATE ION, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 著者 Holton, S.J, Wortmann, L, Braeuer, N, Irlbacher, H, Weiske, J, Lechner, C, Meier, R, Puetter, V, Christ, C, ter Laak, T, Lienau, P, Lesche, R, Nicke, B, Bauser, M, Haegebarth, A, von Nussbaum, F, Mumberg, D, Lemos, C. 登録日 2020-04-07 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64, 2021
6YM4	Crystal structure of BAY-297 with PIP4K2A 分子名称: (2~{R})-2-[[2-[4-(3-chloranyl-2-fluoranyl-phenyl)phenyl]-3-cyano-1,7-naphthyridin-4-yl]amino]butanamide, GLYCEROL, Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 著者 Holton, S.J, Wortmann, L, Braeuer, N, Irlbacher, H, Weiske, J, Lechner, C, Meier, R, Puetter, V, Christ, C, ter Laak, T, Lienau, P, Lesche, R, Nicke, B, Bauser, M, Haegebarth, A, von Nussbaum, F, Mumberg, D, Lemos, C. 登録日 2020-04-07 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A. J.Med.Chem., 64, 2021
8H2T	Cryo-EM structure of IadD/E dioxygenase bound with IAA 分子名称: 1H-INDOL-3-YLACETIC ACID, Aromatic-ring-hydroxylating dioxygenase beta subunit, FE (III) ION, ... 著者 Yu, G, Li, Z, Zhang, H. 登録日 2022-10-07 公開日 2023-06-14 最終更新日 2024-01-03 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Structural and biochemical characterization of the key components of an auxin degradation operon from the rhizosphere bacterium Variovorax. Plos Biol., 21, 2023
5KKS	ROCK 1 bound to azaindole thiazole inhibitor 分子名称: 2-[3-(methylsulfonylamino)phenyl]-~{N}-[4-(1~{H}-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]ethanamide, Rho-associated protein kinase 1 著者 Jacobs, M.D. 登録日 2016-06-22 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors Bioorg.Med.Chem.Lett., 2018

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