PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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7NKV	PaaR2 regulator N-terminal domain 分子名称: Phage repressor protein CI 著者 Prolic-Kalinsek, M, Loris, R, Volkov, A.N. 登録日 2021-02-19 公開日 2022-03-02 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Regulation of the Escherichia coli paaR2-paaA2-ParD2 toxin-antitoxin system To Be Published
6VOA	Cryo-EM structure of the BBSome-ARL6 complex 分子名称: ADP-ribosylation factor-like protein 6, BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, ... 著者 Yang, S, Walz, T, Nachury, M.V. 登録日 2020-01-30 公開日 2020-06-24 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes. Elife, 9, 2020
6VRB	Cryo-EM structure of AcrVIA1-Cas13(crRNA) complex 分子名称: AcrVIA1, CRISPR-associated endoribonuclease Cas13a, RNA (52-MER) 著者 Jia, N, Meeske, A.J, Marraffini, L.A, Patel, D.J. 登録日 2020-02-07 公開日 2020-06-10 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science, 369, 2020
7NTH	Structure of TAK1 in complex with compound 54 分子名称: 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{R})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{H}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. 登録日 2021-03-09 公開日 2021-04-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
7NTI	Structure of TAK1 in complex with compound 22 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, ... 著者 Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. 登録日 2021-03-09 公開日 2021-04-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
7NPL	ALPHA-1 ANTITRYPSIN (C232S) COMPLEXED WITH cmpd 11 分子名称: Alpha-1-antitrypsin, GLYCEROL, N-((1S,2R)-1-(3-chloro-2-methylphenyl)-1-hydroxypentan-2-yl)-2-oxoindoline-4-carboxamide 著者 Chung, C. 登録日 2021-02-27 公開日 2021-04-07 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 The development of highly potent and selective small molecule correctors of Z alpha 1 -antitrypsin misfolding. Bioorg.Med.Chem.Lett., 41, 2021
1KPF	PKCI-SUBSTRATE ANALOG 分子名称: ADENOSINE MONOPHOSPHATE, PROTEIN KINASE C INTERACTING PROTEIN 著者 Lima, C.D, Klein, M.G, Hendrickson, W.A. 登録日 1997-09-25 公開日 1998-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-based analysis of catalysis and substrate definition in the HIT protein family. Science, 278, 1997
1KXU	CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE 分子名称: CYCLIN H 著者 Kim, K.K, Chamberin, H.M, Morgan, D.O, Kim, S.-H. 登録日 1996-08-08 公開日 1997-01-27 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Nat.Struct.Biol., 3, 1996
7NPK	ALPHA-1 ANTITRYPSIN C232S COMPLEXED WITH CMPD3 分子名称: Alpha-1-antitrypsin, GLYCEROL, N-((1S,2R)-1-hydroxy-1-(o-tolyl)pentan-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxamide 著者 Chung, C. 登録日 2021-02-27 公開日 2021-04-07 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 The development of highly potent and selective small molecule correctors of Z alpha 1 -antitrypsin misfolding. Bioorg.Med.Chem.Lett., 41, 2021
4PLI	Structure of the chromodomain of MRG2 in complex with H3K36me3 分子名称: At1g02740, H3K36me3 著者 Liu, Y, Huang, Y. 登録日 2014-05-18 公開日 2015-07-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.651 Å) 主引用文献 Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. Plos Genet., 10, 2014
5HW7	Candida albicans FKBP12 apo protein in P21212 space group 分子名称: FK506-binding protein 1 著者 Tonthat, N.K, Schumacher, M.A. 登録日 2016-01-28 公開日 2016-09-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.291 Å) 主引用文献 Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio, 7, 2016
4PN7	Crystal Structure of the TFIIH p34 N-terminal Domain 分子名称: Putative transcription factor 著者 Schmitt, D.R, Kuper, J, Elias, A, Kisker, C. 登録日 2014-05-23 公開日 2014-07-23 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 The Structure of the TFIIH p34 Subunit Reveals a Von Willebrand Factor A Like Fold. Plos One, 9, 2014
5HYR	Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-SP2 and Estradiol 分子名称: ESTRADIOL, Estrogen receptor, GLYCEROL, ... 著者 Fanning, S.W, Speltz, T.E, Mayne, C.G, Tajkhorshid, E, Greene, G.L, Moore, T.W. 登録日 2016-02-01 公開日 2016-05-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.271 Å) 主引用文献 Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew.Chem.Int.Ed.Engl., 55, 2016
1LIF	THE ADIPOCYTE LIPID-BINDING PROTEIN AT 1.6 ANGSTROMS RESOLUTION: CRYSTAL STRUCTURES OF THE APOPROTEIN AND WITH BOUND SATURATED AND UNSATURATED FATTY ACIDS 分子名称: ADIPOCYTE LIPID-BINDING PROTEIN, STEARIC ACID 著者 Zu, Z, Bernlohr, D.A, Banaszak, L.J. 登録日 1993-12-21 公開日 1994-04-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The adipocyte lipid-binding protein at 1.6-A resolution. Crystal structures of the apoprotein and with bound saturated and unsaturated fatty acids. J.Biol.Chem., 268, 1993
5THU	Crystal Structure of G304A HDAC8 in complex with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, POTASSIUM ION, ... 著者 Porter, N.J, Christianson, D.W. 登録日 2016-09-30 公開日 2016-12-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8. Biochemistry, 55, 2016
5TLD	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol 分子名称: (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol, Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-11 公開日 2017-01-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.375 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5TMO	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Arene Core OBHS derivative, phenyl 4,4''-dihydroxy-[1,1':2',1''-terphenyl]-4'-sulfonate 分子名称: Estrogen receptor, Nuclear receptor coactivator 2, phenyl 4,4''-dihydroxy-[1,1':2',1''-terphenyl]-4'-sulfonate 著者 Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-13 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.172 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5HTG	Structure of apo P1 form of Candida albicans FKBP12 分子名称: FK506-binding protein 1 著者 Schumacher, M.A. 登録日 2016-01-26 公開日 2016-09-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio, 7, 2016
5HUW	Structure of HSV-1 Large Terminase NLS bound to importin alpha 分子名称: HSV1 large terminase NLS, Importin subunit alpha-1 著者 Sankhala, R.S, Lokareddy, R.K, Cingolani, G. 登録日 2016-01-27 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. J.Biol.Chem., 291, 2016
4NYV	Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand 分子名称: 6-bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one, CREB-binding protein 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, Martin, S, Monteiro, O.P, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-12-11 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand TO BE PUBLISHED
4O0P	Crystal Structure of D. radiodurans Bacteriophytochrome Photosensory Core Module in its Dark Form 分子名称: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome 著者 Takala, H, Ihalainen, J.A, Westenhoff, S. 登録日 2013-12-14 公開日 2014-05-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Signal amplification and transduction in phytochrome photosensors Nature, 509, 2014
5TLL	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with (E)-2-chloro-4'-hydroxy-4-((hydroxyiminio)methyl)-[1,1'-biphenyl]-3-olate 分子名称: 2-chloro-4-[(E)-(hydroxyimino)methyl][1,1'-biphenyl]-3,4'-diol, Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-11 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.423 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
5TLT	Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with octane-1,8-diyl bis(2,3-bis(4-hydroxyphenyl)pentanoate) 分子名称: 8-{[2,3-bis(4-hydroxyphenyl)pentanoyl]oxy}octyl (2R,3S)-2,3-bis(4-hydroxyphenyl)pentanoate, Estrogen receptor, NUCLEAR RECEPTOR COACTIVATOR 2 著者 Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Nowak, J, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2016-10-12 公開日 2017-01-18 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.903 Å) 主引用文献 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017
8WZD	The Crystal Structure of PKCi from Biortus 分子名称: Adenosine 5'-monophosphoramidase HINT1 著者 Wang, F, Cheng, W, Lv, Z, Ju, C, Ni, C. 登録日 2023-11-01 公開日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 The Crystal Structure of PKCi from Biortus To Be Published
1NON	PyrR, the regulator of the pyrimidine biosynthetic operon in Bacillus caldolyticus 分子名称: PyrR bifunctional protein 著者 Switzer, R.L, Chander, P, Smith, J.L, Halbig, K.M, Miller, J.K, Bonner, H.K, Grabner, G.K. 登録日 2003-01-16 公開日 2004-05-25 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of the Nucleotide Complex of PyrR, the pyr Attenuation Protein from Bacillus caldolyticus, Suggests Dual Regulation by Pyrimidine and Purine Nucleotides J.Bacteriol., 187, 2005

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