8TTE
 
 | | Protonated state of NorA at pH 5.0 | | 分子名称: | FabDA1 CDRH3 loop, Quinolone resistance protein NorA | | 著者 | Li, J.P, Li, Y, Koide, A, Kuang, H.H, Torres, V.J, Koide, S, Wang, D.N, Traaseth, N.J. | | 登録日 | 2023-08-13 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Proton-coupled transport mechanism of the efflux pump NorA.
Nat Commun, 15, 2024
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8TTB
 | | Cryo-EM structure of the PP2A:B55-ARPP19 complex | | 分子名称: | FE (III) ION, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... | | 著者 | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | | 登録日 | 2023-08-13 | | 公開日 | 2023-10-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Nature, 625, 2024
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8TT7
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8TT5
 | | Pseudomonas fluorescens isocyanide hydratase pH=8.3 | | 分子名称: | 1,2-ETHANEDIOL, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | | 主引用文献 | Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography.
Biorxiv, 2023
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8TT4
 | | Pseudomonas fluorescens isocyanide hydratase pH=6.0 | | 分子名称: | 1,2-ETHANEDIOL, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography.
Biorxiv, 2023
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8TT3
 | | S. thermodepolymerans KpsM-KpsE in Glycolipid 2 state with rigid body fitted KpsT | | 分子名称: | (2R,5S,8S)-2,5-dihydroxy-5,10-dioxo-8-[(undecanoyloxy)methyl]-4,6,9-trioxa-5lambda~5~-phosphahenicosan-1-yl 3-deoxy-alpha-L-altro-oct-2-ulopyranosidonic acid, ABC transporter ATP-binding protein, Capsular biosynthesis protein, ... | | 著者 | Kuklewicz, J, Zimmer, J. | | 登録日 | 2023-08-12 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular insights into capsular polysaccharide secretion.
Nature, 628, 2024
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8TT2
 | | Pseudomonas fluorescens isocyanide hydratase pH=5.4 | | 分子名称: | 1,2-ETHANEDIOL, Isonitrile hydratase InhA | | 著者 | Wilson, M.A, Smith, N, Dasgupta, M, Dolamore, C. | | 登録日 | 2023-08-12 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography.
Biorxiv, 2023
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8TT1
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8TT0
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8TSZ
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8TSY
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8TSX
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8TSW
 | | S. thermodepolymerans KpsMT-KpsE Apo 1 | | 分子名称: | ABC transporter ATP-binding protein, Capsular biosynthesis protein, Transport permease protein | | 著者 | Kuklewicz, J, Zimmer, J. | | 登録日 | 2023-08-12 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Molecular insights into capsular polysaccharide secretion.
Nature, 628, 2024
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8TSV
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8TSU
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8TSS
 | | Open, inward-facing MsbA structure (OIF3) | | 分子名称: | ATP-binding transport protein MsbA | | 著者 | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | 登録日 | 2023-08-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSR
 | | Open, inward-facing MsbA structure (OIF4) | | 分子名称: | ATP-binding transport protein MsbA | | 著者 | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | 登録日 | 2023-08-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSQ
 | | Open, inward-facing MsbA structure (OIF2) | | 分子名称: | ATP-binding transport protein MsbA | | 著者 | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | 登録日 | 2023-08-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSP
 | | Open, inward-facing MsbA structure (OIF1) | | 分子名称: | ATP-binding transport protein MsbA | | 著者 | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | 登録日 | 2023-08-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSO
 | | KDL bound, nucleotide-free MsbA in open, outward-facing conformation | | 分子名称: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ATP-binding transport protein MsbA, PENTAETHYLENE GLYCOL MONODECYL ETHER | | 著者 | Yang, B, Zhang, T, Lyu, J, Laganowsky, A.D, Zhao, M. | | 登録日 | 2023-08-11 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Native mass spectrometry captures snapshots of the MsbA transport cycle
To Be Published
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8TSL
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8TSI
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8TSH
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8TSD
 | | Human PI3K p85alpha/p110alpha bound to RLY-2608 | | 分子名称: | N-{(3R,6M)-3-(2-chloro-5-fluorophenyl)-6-[(4S)-5-cyano[1,2,4]triazolo[1,5-a]pyridin-6-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}-3-fluoro-5-(trifluoromethyl)benzamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024
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8TSC
 | | Human PI3K p85alpha/p110alpha H1047R bound to compound 3 | | 分子名称: | (1S)-7-[3-fluoro-5-(trifluoromethyl)benzamido]-N-methyl-1-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-isoindole-5-carboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Holliday, M, Tang, Y, Bulku, A, Wilbur, J, Fraser, J. | | 登録日 | 2023-08-11 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.62 Å) | | 主引用文献 | Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3K alpha Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov, 14, 2024
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