PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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5GGA	Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-GDP, 8-oxo-GMP and pyrophosphate 分子名称: Hydrolase, NUDIX family protein, MAGNESIUM ION, ... 著者 Arif, S.M, Patil, A.G, Varshney, U, Vijayan, M. 登録日 2016-06-15 公開日 2017-04-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association Acta Crystallogr D Struct Biol, 73, 2017
4NL3	Crystal Structure of Listeria monocytogenes Hfq in complex with U6 RNA 分子名称: 5'-R(*UP*UP*UP*UP*UP*U)-3', Protein hfq 著者 Kovach, A.R, Brennan, R.G. 登録日 2013-11-13 公開日 2014-09-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. Rna, 20, 2014
5GGD	Crystal structure of Mycobacterium smegmatis MutT1 in complex with phosphate and magnesium ions (excess magnesium, II) 分子名称: Hydrolase, NUDIX family protein, MAGNESIUM ION, ... 著者 Arif, S.M, Patil, A.G, Varshney, U, Vijayan, M. 登録日 2016-06-15 公開日 2017-04-19 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association Acta Crystallogr D Struct Biol, 73, 2017
7MLK	Crystal structure of human PI3Ka (p110a subunit) with MMV085400 bound to the active site determined at 2.9 angstroms resolution 分子名称: 4-[6-(3,4,5-trimethoxyanilino)pyrazin-2-yl]benzamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 著者 Krake, S.H, Martinez, P.D.G, Poggi, M.L, Ferreira, M.S, Aguiar, A.C.C, Souza, G.E, Wenlock, M, Jones, B, Steinbrecher, T, Day, T, McPhail, J, Burke, J, Yeo, T, Mok, S, Uhlemann, A.C, Fidock, D.A, Chen, P, Grodsky, N, Deng, Y.L, Guido, R.V.C, Campbell, S.F, Willis, P.A, Dias, L.C. 登録日 2021-04-28 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Discovery of 2,6-disubstituted pyrazines as potent PI4K inhibitors with antimalarial activity To Be Published
8JYH	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid C 分子名称: 7-[5-[(2~{S})-2-azanyl-3-oxidanyl-3-oxidanylidene-propyl]-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
8JYJ	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid A 分子名称: 7-[5-(2-acetamidoethyl)-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,HIV-1 Reverse Transcriptase RNase H active domain, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
4O01	Crystal Structure of D. radiodurans Bacteriophytochrome Photosensory Core Module in its Illuminated Form 分子名称: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome 著者 Takala, H, Ihalainen, J.A, Westenhoff, S. 登録日 2013-12-13 公開日 2014-05-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 Signal amplification and transduction in phytochrome photosensors Nature, 509, 2014
8JYI	Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with laccaic acid E 分子名称: 7-[5-(2-azanylethyl)-2-oxidanyl-phenyl]-3,5,6,8-tetrakis(oxidanyl)-9,10-bis(oxidanylidene)anthracene-1,2-dicarboxylic acid, MANGANESE (II) ION, Pol protein,Pol protein,Ribonuclease H, ... 著者 Ito, Y, Lu, H, Kitajima, M, Ishikawa, H, Nakata, Y, Iwatani, Y, Hoshino, T. 登録日 2023-07-03 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. J.Nat.Prod., 86, 2023
5GJK	Crystal Structure of BAF47 and BAF155 Complex 分子名称: GLYCEROL, PHOSPHATE ION, SWI/SNF complex subunit SMARCC1, ... 著者 Yan, L, Qian, C. 登録日 2016-06-30 公開日 2017-06-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.052 Å) 主引用文献 Structural Insights into BAF47 and BAF155 Complex Formation. J. Mol. Biol., 429, 2017
5GQD	Crystal structure of covalent glycosyl-enzyme intermediate of xylanase mutant (T82A, N127S, and E128H) from Streptomyces olivaceoviridis E-86 分子名称: Beta-xylanase, GLYCEROL, beta-D-xylopyranose-(1-4)-alpha-D-xylopyranose 著者 Suzuki, R, Fujimoto, Z, Kaneko, S, Kuno, A. 登録日 2016-08-07 公開日 2017-08-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Azidolysis by the Formation of Stable Ser-His Catalytic Dyad in a Glycoside Hydrolase Family 10 Xylanase Mutant J.Appl.Glyosci., 65, 2019
4ORC	Crystal structure of mammalian calcineurin 分子名称: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... 著者 Ma, L, Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. 登録日 2014-02-11 公開日 2015-05-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published
6VBU	Structure of the bovine BBSome complex 分子名称: BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, Bardet-Biedl syndrome 2 protein homolog, ... 著者 Singh, S.K, Gui, M, Koh, F, Yip, M.C.J, Brown, A. 登録日 2019-12-19 公開日 2020-01-29 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure and activation mechanism of the BBSome membrane protein trafficking complex. Elife, 9, 2020
5UJD	SbnI from Staphylococcus pseudintermedius 分子名称: FORMIC ACID, Siderophore biosynthesis protein SbnI 著者 Murphy, M.E.P, Verstraete, M.M. 登録日 2017-01-17 公開日 2018-01-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus . J.Biol.Chem., 294, 2019
8DML	Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt chenodeoxycholate 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHENODEOXYCHOLIC ACID, ... 著者 Tomchick, D.R, Orth, K, Zou, A.J. 登録日 2022-07-08 公開日 2023-06-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus. J.Biol.Chem., 299, 2023
5T10	PelC dodecamer from Paraburkholderia phytofirmans, space group P6 分子名称: Uncharacterized protein 著者 Marmont, L.S, Howell, P.L. 登録日 2016-08-17 公開日 2017-03-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4987 Å) 主引用文献 Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8DO6	The structure of S. epidermidis Cas10-Csm bound to target RNA 分子名称: CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, CRISPR system Cms protein Csm4, ... 著者 Paraan, M, Stagg, S.M, Dunkle, J.A. 登録日 2022-07-12 公開日 2023-06-21 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems. Plos One, 18, 2023
5FPE	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site. 分子名称: 3-AMINO-1,2,4-TRIAZOLE, HEAT SHOCK-RELATED 70KDA PROTEIN 2 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
7NH4	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
7NH5	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 6 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{H}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
6VBV	Structure of the bovine BBSome:ARL6:GTP complex 分子名称: ADP-ribosylation factor-like protein 6, BBS1 domain-containing protein, Bardet-Biedl syndrome 18 protein, ... 著者 Singh, S.K, Gui, M, Koh, F, Yip, M.C.J, Brown, A. 登録日 2019-12-19 公開日 2020-01-29 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure and activation mechanism of the BBSome membrane protein trafficking complex. Elife, 9, 2020
1LIB	THE ADIPOCYTE LIPID-BINDING PROTEIN AT 1.6 ANGSTROMS RESOLUTION: CRYSTAL STRUCTURES OF THE APOPROTEIN AND WITH BOUND SATURATED AND UNSATURATED FATTY ACIDS 分子名称: ADIPOCYTE LIPID-BINDING PROTEIN 著者 Zu, Z, Bernlohr, D.A, Banaszak, L.J. 登録日 1993-12-21 公開日 1994-04-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The adipocyte lipid-binding protein at 1.6-A resolution. Crystal structures of the apoprotein and with bound saturated and unsaturated fatty acids. J.Biol.Chem., 268, 1993
5FPY	Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 5-bromo-1-methyl-1H-indole-2-carboxylic acid (AT21457) in an alternate binding site. 分子名称: 5-bromo-1-methyl-1H-indole-2-carboxylic acid, SERINE PROTEASE NS3 著者 Davies, T.G, Jhoti, H, Ludlow, R.F, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-12-03 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPD	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site. 分子名称: HEAT SHOCK-RELATED 70KDA PROTEIN 2, PYRAZINE-2-CARBOXAMIDE 著者 Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. 登録日 2015-11-28 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
4OR9	Crystal structure of human calcineurin 分子名称: CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... 著者 Li, S.J, Wang, J, Wu, J.W, Wang, Z.X. 登録日 2014-02-11 公開日 2015-05-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Cooperative autoinhibition and multi-level activation mechanisms of calcineurin To be Published
7NBW	Crystal structure of PqsR (MvfR) ligand-binding domain in complex with a pyridin agonist 分子名称: Transcriptional regulator MvfR, ~{N}-[3-(4-fluorophenyl)prop-2-ynyl]-2-(trifluoromethyl)pyridin-4-amine 著者 Schmelz, S, Blankenfeldt, W. 登録日 2021-01-28 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR. Eur.J.Med.Chem., 226, 2021

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