PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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4WTM	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP 分子名称: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER CC, ... 著者 Edwards, T.E, Appleby, T.C, Fox III, D. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTI	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-ACGG, RNA PRIMER 5'-PCC, MN2+, AND GDP 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTK	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-AGCC, RNA PRIMER 5'-PGG, MN2+, AND CDP 分子名称: 1,2-ETHANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTL	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UACC, RNA PRIMER 5'-PGG, MN2+, AND UDP 分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
6QCT	Influenza B polymerase elongation complex 分子名称: 3 end, 5 end, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2018-12-30 公開日 2019-06-05 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
4WTD	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ... 著者 Edwards, T.E, Fox III, D, Appleby, T.C. 登録日 2014-10-29 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTF	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU 分子名称: 2'-C-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ... 著者 Edwards, T.E, Appleby, T.C, Mcgrath, M.E. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTA	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH UDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU 分子名称: CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER TEMPLATE CAAAAUUU, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-29 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTC	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH CDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AGAAAUUU 分子名称: CHLORIDE ION, CYTIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-29 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTE	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GDP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-ACAAAUUU 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-29 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WTG	CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH SOFOSBUVIR DIPHOSPHATE GS-607596, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU 分子名称: 2'-deoxy-2'-fluoro-2'-methyluridine 5'-(trihydrogen diphosphate), CHLORIDE ION, MANGANESE (II) ION, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-30 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4WT9	APO CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH E86Q E87Q S15G C223H V321I AND DELTA8 MUTATIONS 分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... 著者 Edwards, T.E, Appleby, T.C. 登録日 2014-10-29 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015
4NLT	Poliovirus Polymerase - S291P Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2014-03-26 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
7EU1	The cryo-EM structure of A. thaliana Pol IV-RDR2 holoenzyme 分子名称: DNA-directed RNA polymerase IV subunit 1, DNA-directed RNA polymerases II and IV subunit 5A, DNA-directed RNA polymerases II, ... 著者 Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. 登録日 2021-05-15 公開日 2021-12-29 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.86 Å) 主引用文献 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA. Science, 374, 2021
7EU0	The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex 分子名称: DNA (33-MER), DNA (5'-D(*CP*TP*GP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase IV subunit 1, ... 著者 Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. 登録日 2021-05-15 公開日 2021-12-29 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.16 Å) 主引用文献 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA. Science, 374, 2021
4NLX	Poliovirus Polymerase - G289A/C290V Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2014-03-26 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
3CJ2	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: 4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}aniline, NICKEL (II) ION, RNA-directed RNA polymerase 著者 Kissinger, c. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
6QCS	Influenza B polymerase pre-initiation complex 分子名称: 3 end, 5 end, Capped RNA, ... 著者 Cusack, S, Kouba, T. 登録日 2018-12-30 公開日 2019-06-05 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
7RKP	The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with cyclic compound SJ001034733 分子名称: (5R)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2,6(28),11(27),12,14,22,24-octaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2021-07-22 公開日 2022-07-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
4NLQ	Poliovirus Polymerase - C290F Loop Mutant 分子名称: ACETIC ACID, PENTAETHYLENE GLYCOL, RNA-directed RNA polymerase 3D-POL, ... 著者 Sholders, A.J, Peersen, O.B. 登録日 2013-11-14 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Distinct conformations of a putative translocation element in poliovirus polymerase. J.Mol.Biol., 426, 2014
1HI0	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 plus initiation complex 分子名称: DNA (5'-(*TP*TP*TP*CP*C)-3'), GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. 登録日 2000-12-31 公開日 2001-03-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
5QJ1	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide 分子名称: 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, RNA-dependent RNA polymerase, ... 著者 Sheriff, S. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
5QJ0	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide 分子名称: 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, GLYCEROL, NONAETHYLENE GLYCOL, ... 著者 Sheriff, S. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
2ZTT	Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus 分子名称: Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit 著者 Sugiyama, K, Obayashi, E, Park, S.-Y. 登録日 2008-10-08 公開日 2009-06-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase Embo J., 28, 2009
3CJ5	Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments 分子名称: N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide, RNA-directed RNA polymerase 著者 Hendle, j. 登録日 2008-03-12 公開日 2008-04-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008

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