PDB: 621 件ウェブページステータス検索Chemie searchBIRD

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6YPL	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-037 分子名称: (2-methylsulfonylphenyl)methanol, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-16 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YPY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-123 分子名称: 14-3-3 protein sigma, 4-(4-ethanoylpiperazin-1-yl)sulfonylbenzaldehyde, p65pS45 著者 Wolter, M, Ottmann, C. 登録日 2020-04-16 公開日 2020-09-23 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YQ2	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-129 分子名称: 14-3-3 protein sigma, 4-[(2~{R},6~{S})-2,6-dimethylmorpholin-4-yl]sulfonylbenzaldehyde, p65pS45 著者 Wolter, M, Ottmann, C. 登録日 2020-04-16 公開日 2020-09-23 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YR5	14-3-3 sigma in complex with hDMX-367 peptide 分子名称: 14-3-3 protein sigma, Protein Mdm4, SULFATE ION 著者 Wolter, M, Srdanovic, S, Ottman, C, Warriner, S, Wilson, A. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR6	14-3-3 sigma in complex with hDM2-186 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IODIDE ION, ... 著者 Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR7	14-3-3 sigma in complex with hDMX-342+367 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein Mdm4 著者 Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.105 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6ZBT	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342 分子名称: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like 著者 Joshi, R, Kalabova, D, Obsil, T, Obsilova, V. 登録日 2020-06-09 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.79948521 Å) 主引用文献 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
6ZC9	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448 分子名称: 1,1,1,3,3,3-hexafluoropropan-2-ol, 14-3-3 protein gamma, E3 ubiquitin-protein ligase NEDD4-like 著者 Pohl, P, Kalabova, D, Obsil, T, Obsilova, V. 登録日 2020-06-10 公開日 2021-07-21 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.89895988 Å) 主引用文献 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
6ZCJ	14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-06-11 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. Febs Lett., 595, 2021
6ZFD	14-3-3 zeta bound to the phosphorylated 18E6 C-terminus 分子名称: 14-3-3 protein zeta/delta,Protein E6, GLYCEROL 著者 Gogl, G, Tugaeva, K.V, Sluchanko, N.N, Trave, G. 登録日 2020-06-17 公開日 2021-02-17 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
6ZFG	14-3-3 zeta chimera with 18E6 and fusicoccin 分子名称: 14-3-3 protein zeta/delta,Protein E6, FUSICOCCIN, GLYCEROL 著者 Gogl, G, Tugaeva, K, Sluchanko, N.N, Trave, G. 登録日 2020-06-17 公開日 2021-02-17 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms. Nat Commun, 12, 2021
6ZVB	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 24h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVC	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 48h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVD	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVE	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
7A6R	Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif 分子名称: 14-3-3 protein gamma, DAPK2 C-terminal peptide 著者 Horvath, M, Obsilova, V, Obsil, T. 登録日 2020-08-26 公開日 2021-08-25 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
7A6Y	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A 分子名称: 14-3-3 protein gamma, DAPK2 C-terminal peptide, FUSICOCCIN 著者 Horvath, M, Obsilova, V, Obsil, T. 登録日 2020-08-27 公開日 2021-08-25 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
7AEW	14-3-3 sigma bound to bis-phosphorylated aminopeptidase N (APN, CD13) via canonical and non-canonical binding motifs 分子名称: 14-3-3 protein sigma, Aminopeptidase N, CHLORIDE ION, ... 著者 Kiehstaller, S, Hennig, S. 登録日 2020-09-18 公開日 2020-11-04 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 MMP activation-associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J.Biol.Chem., 295, 2020
7AOG	14-3-3 sigma in complex with Pin1 binding site pS72 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-10-14 公開日 2021-06-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AXN	14-3-3 sigma in complex with Pin1 binding site pS72 and covalently bound TCF521-026 分子名称: 14-3-3 protein sigma, 3-chloranyl-4-imidazol-1-yl-benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-10 公開日 2021-06-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AYF	14-3-3 sigma with Pin1 binding site pS72 and covalently bound TCF521-110 分子名称: 14-3-3 protein sigma, 6-(2-bromanylimidazol-1-yl)pyridine-3-carbaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-12 公開日 2021-06-16 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.752 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ1	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 分子名称: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-14 公開日 2021-06-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ2	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 分子名称: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-14 公開日 2021-06-16 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.081 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7B13	14-3-3sigma in complex with SHN3pS542 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pS542 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-11-23 公開日 2021-09-29 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 14-3-3 sigma in complex with phosphopeptides To Be Published
7B15	14-3-3sigma in complex with SHN3pT869 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SHN3pT869 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-11-23 公開日 2021-09-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 14-3-3 sigma in complex with phosphopeptides To Be Published

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