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1GL9
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Archaeoglobus fulgidus reverse gyrase complexed with ADPNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, REVERSE GYRASE
著者Rodriguez, A.C, Stock, D.
登録日2001-08-30
公開日2002-02-11
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal Structure of Reverse Gyrase: Insights Into the Positive Supercoiling of DNA.
Embo J., 21, 2002
6RML
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BU of 6rml by Molmil
Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
5L3J
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BU of 5l3j by Molmil
ESCHERICHIA COLI DNA GYRASE B IN COMPLEX WITH BENZOTHIAZOLE-BASED INHIBITOR
分子名称: 2-[[2-[[4,5-bis(bromanyl)-1~{H}-pyrrol-2-yl]carbonylamino]-1,3-benzothiazol-6-yl]amino]-2-oxidanylidene-ethanoic acid, DNA gyrase subunit B, IODIDE ION
著者Gjorgjieva, M, Tomasic, T, Barancokova, M, Katsamakas, S, Ilas, J, Montalvao, S, Tammella, P, Peterlin Masic, L, Kikelj, D.
登録日2016-05-23
公開日2016-08-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors.
J.Med.Chem., 59, 2016
8QQU
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Asymetric subunit of E. coli DNA gyrase bound to a linear part of a DNA minicircle
分子名称: DNA (16-MER), DNA gyrase subunit A, DNA gyrase subunit B
著者Vayssieres, M, Lamour, V.
登録日2023-10-06
公開日2024-04-10
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of DNA crossover capture by Escherichia coli DNA gyrase.
Science, 384, 2024
8QQS
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E. coli DNA gyrase bound to a linear part of a DNA minicircle
分子名称: DNA (30-MER), DNA gyrase subunit A, DNA gyrase subunit B
著者Vayssieres, M, Lamour, V.
登録日2023-10-06
公開日2024-04-10
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of DNA crossover capture by Escherichia coli DNA gyrase.
Science, 384, 2024
8QDX
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E. coli DNA gyrase bound to a DNA crossover
分子名称: DNA gyrase subunit A, DNA gyrase subunit B, DNA minicircle
著者Vayssieres, M, Lamour, V.
登録日2023-08-30
公開日2024-04-10
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of DNA crossover capture by Escherichia coli DNA gyrase.
Science, 384, 2024
8BP2
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BU of 8bp2 by Molmil
2.8A STRUCTURE OF ZOLIFLODACIN WITH S.AUREUS DNA GYRASE AND DNA
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA (20-MER), DNA gyrase subunit A, ...
著者Bax, B.D, Morgan, H, Warren, A.J.
登録日2022-11-15
公開日2023-02-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A 2.8 angstrom Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA Gyrase.
Int J Mol Sci, 24, 2023
6YD9
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Ecoli GyrB24 with inhibitor 16a
分子名称: 1,2-ETHANEDIOL, DNA gyrase subunit B, N-[6-(3-azanylpropanoylamino)-1,3-benzothiazol-2-yl]-3,4-bis(chloranyl)-5-methyl-1H-pyrrole-2-carboxamide
著者Barancokova, M, Skok, Z, Benek, O, Cruz, C.D, Tammela, P, Tomasic, T, Zidar, N, Masic, L.P, Zega, A, Stevenson, C.E.M, Mundy, J, Lawson, D.M, Maxwell, A.M, Kikelj, D, Ilas, J.
登録日2020-03-20
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.
Acs Med.Chem.Lett., 11, 2020
6Z1A
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Ternary complex of Staphylococcus aureus DNA gyrase with AMK12 and DNA
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Kolaric, A, Germe, T, Hrast, M, Stevenson, C.E.M, Lawson, D.M, Burton, N, Voros, J, Maxwell, A, Minovski, N, Anderluh, M.
登録日2020-05-13
公開日2020-11-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds.
Nat Commun, 12, 2021
4MOT
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BU of 4mot by Molmil
Structure of Streptococcus pneumonia pare in complex with AZ13072886
分子名称: 1-[4-(3-methylbutyl)-5-oxo-6-(pyridin-3-yl)-4,5-dihydro[1,3]thiazolo[5,4-b]pyridin-2-yl]-3-prop-2-en-1-ylurea, Topoisomerase IV subunit B
著者Ogg, D, Boriack-Sjodin, P.A.
登録日2013-09-12
公開日2013-11-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Thiazolopyridone ureas as DNA gyrase B inhibitors: Optimization of antitubercular activity and efficacy.
Bioorg.Med.Chem.Lett., 24, 2014
4N0A
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BU of 4n0a by Molmil
Crystal structure of Lsm2-3-Pat1C complex from Saccharomyces cerevisiae
分子名称: DNA topoisomerase 2-associated protein PAT1, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3
著者Wu, D.H.
登録日2013-10-01
公開日2013-12-04
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation
Cell Res., 24, 2014
3IG0
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BU of 3ig0 by Molmil
crystal structure of the second part of the Mycobacterium tuberculosis DNA gyrase reaction core: the TOPRIM domain at 2.1 A resolution
分子名称: DNA gyrase subunit B
著者Piton, J, Aubry, A, Delarue, M, Mayer, C.
登録日2009-07-27
公開日2010-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
Plos One, 5, 2010
3UEO
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BU of 3ueo by Molmil
Crystal structure of TopBP1 BRCT4/5 domains in complex with a phospho-peptide
分子名称: DNA topoisomerase 2-binding protein 1, phospho-peptide
著者Leung, C.C, Glover, J.N.M.
登録日2011-10-31
公開日2013-07-03
最終更新日2014-03-26
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control.
Structure, 21, 2013
7P2W
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BU of 7p2w by Molmil
E.coli GyrB24 with inhibitor LMD92 (EBL2682)
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[[3,4-bis(chloranyl)-5-methyl-1H-pyrrol-2-yl]carbonylamino]-4-[(3-carboxyphenyl)methoxy]-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B, ...
著者Stevenson, C.E.M, Lawson, D.M, Maxwell, A.M, Henderson, S.R, Kikelj, D, Durcik, M, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P.
登録日2021-07-06
公開日2022-07-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
J.Med.Chem., 66, 2023
7P2M
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BU of 7p2m by Molmil
E.coli GyrB24 with inhibitor LMD43 (EBL2560)
分子名称: 2-[[3,4-bis(chloranyl)-5-methyl-1~{H}-pyrrol-2-yl]carbonylamino]-4-phenylmethoxy-1,3-benzothiazole-6-carboxylic acid, DNA gyrase subunit B, PHOSPHATE ION
著者Stevenson, C.E.M, Lawson, D.M, Maxwell, A.M, Henderson, S.R, Kikelj, D, Durcik, M, Zega, A, Zidar, N, Ilas, J, Tomasic, T, Masic, L.P.
登録日2021-07-06
公開日2022-07-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.16 Å)
主引用文献Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
J.Med.Chem., 66, 2023
5NPK
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BU of 5npk by Molmil
1.98A STRUCTURE OF THIOPHENE1 WITH S.AUREUS DNA GYRASE AND DNA
分子名称: CHLORIDE ION, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A, ...
著者Bax, B.D, Chan, P.F, Stavenger, R.A.
登録日2017-04-17
公開日2017-07-12
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NPP
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BU of 5npp by Molmil
2.22A STRUCTURE OF THIOPHENE2 AND GSK945237 WITH S.AUREUS DNA GYRASE AND DNA
分子名称: (1R)-1-[(4-{[(6,7-dihydro[1,4]dioxino[2,3-c]pyridazin-3-yl)methyl]amino}piperidin-1-yl)methyl]-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one, DIMETHYL SULFOXIDE, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ...
著者Bax, B.D, Chan, P.F, Stavenger, R.A.
登録日2017-04-18
公開日2017-07-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6FQV
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BU of 6fqv by Molmil
2.60A BINARY COMPLEX OF S.AUREUS GYRASE with UNCLEAVED DNA
分子名称: DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*GP*GP*CP*CP*GP*TP*AP*CP*GP*CP*TP*T)-3'), DNA gyrase subunit A, DNA gyrase subunit B,DNA gyrase subunit B, ...
著者Bax, B.D, Germe, T, Basque, E, Maxwell, A.
登録日2018-02-14
公開日2018-04-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Nucleic Acids Res., 46, 2018
6FQS
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3.11A complex of S.Aureus gyrase with imidazopyrazinone T3 and DNA
分子名称: 5-cyclopropyl-8-fluoranyl-7-pyridin-4-yl-imidazo[1,2-a]quinoxalin-4-one, DNA (5'-D(*GP*AP*GP*AP*GP*TP*AP*T*GP*GP*CP*CP*AP*TP*AP*CP*TP*CP*TP*T)-3'), DNA gyrase subunit A, ...
著者Bax, B.D, Germe, T, Basque, E, Maxwell, A.
登録日2018-02-14
公開日2018-04-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Nucleic Acids Res., 46, 2018
6FQM
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BU of 6fqm by Molmil
3.06A COMPLEX OF S.AUREUS GYRASE with imidazopyrazinone T1 AND DNA
分子名称: 7-[(3~{S})-3-azanylpyrrolidin-1-yl]-5-cyclopropyl-8-fluoranyl-imidazo[1,2-a]quinoxalin-4-one, DNA (5'-D(*GP*AP*GP*AP*GP*TP*AP*T*GP*GP*CP*CP*AP*TP*AP*CP*TP*CP*T)-3'), DNA gyrase subunit A, ...
著者Bax, B.D, Germe, T, Basque, E, Maxwell, A.
登録日2018-02-14
公開日2018-04-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Nucleic Acids Res., 46, 2018
6RMM
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BU of 6rmm by Molmil
Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
6QTK
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2.31A structure of gepotidacin with S.aureus DNA gyrase and doubly nicked DNA
分子名称: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*G*GP*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), DNA gyrase subunit A, ...
著者Bax, B.D.
登録日2019-02-25
公開日2019-03-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
Acs Infect Dis., 5, 2019
6QTP
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2.37A structure of gepotidacin with S.aureus DNA gyrase and uncleaved DNA
分子名称: (3~{R})-3-[[4-(3,4-dihydro-2~{H}-pyrano[2,3-c]pyridin-6-ylmethylamino)piperidin-1-yl]methyl]-1,4,7-triazatricyclo[6.3.1.0^{4,12}]dodeca-6,8(12),9-triene-5,11-dione, DNA (5'-D(*GP*AP*GP*CP*GP*TP*AP*CP*AP*GP*CP*TP*GP*TP*AP*CP*GP*CP*TP*T)-3'), DNA gyrase subunit A, ...
著者Bax, B.D.
登録日2019-02-25
公開日2019-03-13
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
Acs Infect Dis., 5, 2019
4DDV
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BU of 4ddv by Molmil
Thermotoga maritima reverse gyrase, triclinic form
分子名称: Reverse gyrase, ZINC ION
著者Rudolph, M.G, Klostermeier, D.
登録日2012-01-19
公開日2012-12-26
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.46 Å)
主引用文献Crystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling.
Nucleic Acids Res., 41, 2013
5LM5
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BU of 5lm5 by Molmil
Structure of C-terminal domain from S. cerevisiae Pat1 decapping activator bound to Dcp2 HLM2 peptide (region 435-451)
分子名称: DNA topoisomerase 2-associated protein PAT1, mRNA decapping protein 2
著者Charenton, C, Gaudon-Plesse, C, Fourati, Z, Taverniti, V, Back, R, Kolesnikova, O, Seraphin, B, Graille, M.
登録日2016-07-29
公開日2017-08-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5'-3' mRNA exonuclease in yeast.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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