PDB: 1500 件ウェブページステータス検索Chemie searchBIRD

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2JNB	Solution Structure of RNA-binding protein 15.5K 分子名称: NHP2-like protein 1 著者 Soss, S.E, Flynn, P.F. 登録日 2007-01-04 公開日 2007-12-18 最終更新日 2023-12-20 実験手法 SOLUTION NMR 主引用文献 Functional Implications for a Prototypical K-Turn Binding Protein from Structural and Dynamical Studies of 15.5K Biochemistry, 46, 2007
2MKC	Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex 分子名称: Pre-mRNA leakage protein 1, Pre-mRNA-splicing factor CWC26, U2 snRNP component IST3 著者 Wysoczanski, P, Schneider, C, Xiang, S, Munari, F, Trowitzsch, S, Wahl, M.C, Luhrmann, R, Becker, S, Zweckstetter, M. 登録日 2014-02-04 公開日 2014-09-03 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nat.Struct.Mol.Biol., 21, 2014
4YHV	Yeast Prp3 C-terminal fragment 325-469 分子名称: ACETIC ACID, U4/U6 small nuclear ribonucleoprotein PRP3 著者 Liu, S, Wahl, M.C. 登録日 2015-02-27 公開日 2015-07-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. Elife, 4, 2015
4YHU	Yeast Prp3 C-terminal fragment 296-469 分子名称: U4/U6 small nuclear ribonucleoprotein PRP3, YTTRIUM (III) ION 著者 Liu, S, Wahl, M.C. 登録日 2015-02-27 公開日 2015-07-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. Elife, 4, 2015
6V0P	PRMT5 complex bound to covalent PBM inhibitor BRD6711 分子名称: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide, CHLORIDE ION, GLYCEROL, ... 著者 McMillan, B.J, McKinney, D.C. 登録日 2019-11-19 公開日 2020-11-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021
3NVK	Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle 分子名称: 50S ribosomal protein L7Ae, Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase, NOP5/NOP56 related protein, ... 著者 Xue, S, Wang, R, Li, H. 登録日 2010-07-08 公開日 2011-07-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.209 Å) 主引用文献 Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. Mol.Cell, 39, 2010
3NVM	Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle 分子名称: Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase, NOP5/NOP56 related protein 著者 Xue, S, Wang, R, Li, H. 登録日 2010-07-08 公開日 2011-07-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.408 Å) 主引用文献 Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. Mol.Cell, 39, 2010
7VH9	Solution structure of the chimeric peptide of the first SURP domain of Human SF3A1 and the interacting region of SF1. 分子名称: Splicing factor 3A subunit 1,Splicing factor 1 著者 Muto, Y, Kuwasako, K, Takizawa, M, Kobayashi, N, Sakamoto, T. 登録日 2021-09-21 公開日 2022-09-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1. Protein Sci., 31, 2022
6S8O	Human Brr2 Helicase Region M641C/A1582C 分子名称: U5 small nuclear ribonucleoprotein 200 kDa helicase 著者 Vester, K, Santos, K.F, Wahl, M.C. 登録日 2019-07-10 公開日 2020-01-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.172 Å) 主引用文献 The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
2P8R	Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 carrying R2303K mutant 分子名称: Pre-mRNA-splicing factor Prp8 著者 Zhang, L, Shen, J, Guarnieri, M.T, Heroux, A, Yang, K, Zhao, R. 登録日 2007-03-22 公開日 2007-05-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants Protein Sci., 16, 2007
2P87	Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 分子名称: Pre-mRNA-splicing factor Prp8 著者 Zhang, L, Shen, J, Guarnieri, M.T, Heroux, A, Yang, K, Zhao, R. 登録日 2007-03-21 公開日 2007-05-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants Protein Sci., 16, 2007
7BDK	Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, ... 著者 Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. 登録日 2020-12-21 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
7BDL	Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ADP 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... 著者 Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. 登録日 2020-12-21 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
7BDJ	Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and mant-ATPgammaS 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... 著者 Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. 登録日 2020-12-21 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
7BDI	Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and ATPgammaS 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Pre-mRNA-processing-splicing factor 8, ... 著者 Vester, K, Santos, K.F, Absmeier, E, Wahl, M.C. 登録日 2020-12-21 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2. J.Biol.Chem., 297, 2021
2DT6	Solution structure of the first SURP domain of human splicing factor SF3a120 分子名称: Splicing factor 3 subunit 1 著者 Kuwasako, K, He, F, Inoue, M, Tanaka, A, Sugano, S, Guentert, P, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-07-11 公開日 2006-12-26 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP Structure, 14, 2006
6RMA	Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... 著者 Hamann, F, Neumann, P, Ficner, R. 登録日 2019-05-06 公開日 2020-02-05 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proc.Natl.Acad.Sci.USA, 117, 2020
4MFV	Crystal structure of human CTNNBL1(residues 33~563) 分子名称: Beta-catenin-like protein 1 著者 Ahn, J.W, Kim, S, Kim, K.J. 登録日 2013-08-28 公開日 2014-03-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex Acta Crystallogr.,Sect.D, 70, 2014
6RMC	Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative mRNA splicing factor, ... 著者 Hamann, F, Neumann, P, Schmitt, A, Ficner, R. 登録日 2019-05-06 公開日 2020-02-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proc.Natl.Acad.Sci.USA, 117, 2020
6RM8	Crystal structure of the DEAH-box ATPase Prp2 in complex with Spp2 and ADP 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... 著者 Hamann, F, Neumann, P, Ficner, R. 登録日 2019-05-06 公開日 2020-02-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2. Proc.Natl.Acad.Sci.USA, 117, 2020
4N0T	Core structure of the U6 small nuclear ribonucleoprotein at 1.7 Angstrom resolution 分子名称: SULFATE ION, U4/U6 snRNA-associated-splicing factor PRP24, U6 snRNA 著者 Montemayor, E.J, Curran, E.C, Liao, H, Andrews, K.L, Treba, C.N, Butcher, S.E, Brow, D.A. 登録日 2013-10-02 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Core structure of the U6 small nuclear ribonucleoprotein at 1.7- angstrom resolution. Nat.Struct.Mol.Biol., 21, 2014
7M05	CryoEM structure of PRMT5 bound to covalent PBM-site inhibitor BRD-6988 分子名称: 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McMillan, B.J, McKinney, D.C, Timm, D.E. 登録日 2021-03-10 公開日 2021-03-17 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (2.39 Å) 主引用文献 Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction. J.Med.Chem., 64, 2021
7MXN	PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06939999 分子名称: (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-19 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
7MX7	PRMT5:MEP50 complexed with inhibitor PF-06939999 分子名称: (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-18 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
7MXA	PRMT5:MEP50 complexed with inhibitor PF-06855800 分子名称: 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 McTigue, M, Deng, Y.L, Liu, W, Brooun, A. 登録日 2021-05-18 公開日 2021-11-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.713 Å) 主引用文献 SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022

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