PDB: 498 件ウェブページステータス検索Chemie searchBIRD

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5E10	Crystal Structure of PASTA Domains 1 and 2 of Mycobacterium tuberculosis Protein Kinase B 分子名称: Serine/threonine-protein kinase PknB 著者 Prigozhin, D.M, TB Structural Genomics Consortium (TBSGC) 登録日 2015-09-29 公開日 2016-09-14 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Structural and Genetic Analyses of the Mycobacterium tuberculosis Protein Kinase B Sensor Domain Identify a Potential Ligand-binding Site. J.Biol.Chem., 291, 2016
7V1Z	human Serine beta-lactamase-like protein LACTB 分子名称: Serine beta-lactamase-like protein LACTB, mitochondrial 著者 Zhang, M.H, Yang, M.J. 登録日 2021-08-07 公開日 2022-02-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. Structure, 30, 2022
7V21	human Serine beta-lactamase-like protein LACTB truncation variant 分子名称: Serine beta-lactamase-like protein LACTB, mitochondrial 著者 Zhang, M.H, Yang, M.J. 登録日 2021-08-07 公開日 2022-02-16 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.08 Å) 主引用文献 Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. Structure, 30, 2022
7V1Y	Serine beta-lactamase-like protein LACTB in complex with inhibitor 分子名称: ALA-ALA-B3S, Serine beta-lactamase-like protein LACTB, mitochondrial 著者 Zhang, M.H, Yang, M.J. 登録日 2021-08-07 公開日 2022-02-16 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.82 Å) 主引用文献 Structural basis for the catalytic activity of filamentous human serine beta-lactamase-like protein LACTB. Structure, 30, 2022
2MGV	NMR structure of PASTA domain of PonA2 from Mycobacterium tuberculosis 分子名称: Bifunctional membrane-associated penicillin-binding protein 1A/1B ponA2 著者 Calvanese, L, Falcigno, L, Maglione, C, Marasco, D, Ruggiero, A, Squeglia, F, Berisio, R, D'Auria, G. 登録日 2013-11-11 公開日 2013-12-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis. Biopolymers, 101, 2014
2FFF	Open Form of a Class A Transpeptidase Domain 分子名称: NICKEL (II) ION, penicillin-binding protein 1B 著者 Lovering, A.L, Strynadka, N.C.J. 登録日 2005-12-19 公開日 2006-06-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae. Protein Sci., 15, 2006
1K25	PBP2x from a Highly Penicillin-resistant Streptococcus pneumoniae Clinical Isolate 分子名称: low-affinity PENICILLIN-BINDING PROTEIN 2X 著者 Dessen, A, Mouz, N, Hopkins, J, Dideberg, O. 登録日 2001-09-26 公開日 2001-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations. J.Biol.Chem., 276, 2001
6PL5	Structural coordination of polymerization and crosslinking by a peptidoglycan synthase complex 分子名称: Penicillin-binding protein 2/cell division protein FtsI, Peptidoglycan glycosyltransferase RodA, Unknown peptide 著者 Sjodt, M, Rohs, P.D.A, Erlandson, S.C, Zheng, S, Rudner, D.Z, Bernhardt, T.G, Kruse, A.C. 登録日 2019-06-30 公開日 2020-03-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol, 5, 2020
8VBT	Structure of the monofunctional Staphylococcus aureus PBP1 in its apo form 分子名称: Penicillin-binding protein 1 著者 Bon, C.G, Lee, J, Caveney, N.A, Strynadka, N.C.J. 登録日 2023-12-12 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216, 2024
6FZK	NMR structure of UB2H, regulatory domain of PBP1b from E. coli 分子名称: Penicillin-binding protein 1B 著者 Simorre, J.P, Maya Martinez, R.C, Bougault, C, Egan, A.J.F, Vollmer, W. 登録日 2018-03-15 公開日 2019-02-20 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Induced conformational changes activate the peptidoglycan synthase PBP1B. Mol. Microbiol., 110, 2018
6G9P	Structural basis for the inhibition of E. coli PBP2 分子名称: Peptidoglycan D,D-transpeptidase MrdA 著者 Ruff, M, Levy, N. 登録日 2018-04-11 公開日 2019-05-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62, 2019
6G9S	Structural basis for the inhibition of E. coli PBP2 分子名称: (3~{R},6~{S})-6-(aminomethyl)-4-(1,3-oxazol-5-yl)-3-(sulfooxyamino)-3,6-dihydro-2~{H}-pyridine-1-carboxylic acid, Peptidoglycan D,D-transpeptidase MrdA 著者 Ruff, M, Levy, N. 登録日 2018-04-11 公開日 2019-05-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62, 2019
6G9F	Structural basis for the inhibition of E. coli PBP2 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Peptidoglycan D,D-transpeptidase MrdA 著者 Ruff, M, Levy, N. 登録日 2018-04-10 公開日 2019-05-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design. J.Med.Chem., 62, 2019
7KCV	Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) 分子名称: Penicillin-binding protein 4, ZINC ION 著者 Alexander, J.A.N, Strynadka, N.C.J. 登録日 2020-10-07 公開日 2021-06-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus. J.Antimicrob.Chemother., 76, 2021
1PMD	PENICILLIN-BINDING PROTEIN 2X (PBP-2X) 分子名称: PEPTIDOGLYCAN SYNTHESIS MULTIFUNCTIONAL ENZYME 著者 Pares, S, Mouz, N, Dideberg, O. 登録日 1996-02-05 公開日 1997-02-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Nat.Struct.Biol., 3, 1996
3PBN	Crystal Structure of Apo PBP3 from Pseudomonas aeruginosa 分子名称: Penicillin-binding protein 3 著者 Han, S. 登録日 2010-10-20 公開日 2010-12-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc.Natl.Acad.Sci.USA, 107, 2010
6PL6	Structural coordination of polymerization and crosslinking by a peptidoglycan synthase complex 分子名称: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Penicillin-binding protein 2/cell division protein FtsI, Peptidoglycan glycosyltransferase RodA, ... 著者 Sjodt, M, Rohs, P.D.A, Erlandson, S.C, Zheng, S, Rudner, D.Z, Bernhardt, T.G, Kruse, A.C. 登録日 2019-06-30 公開日 2020-03-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol, 5, 2020
8VBU	Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Oxacillin) inhibited form 分子名称: (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, Penicillin-binding protein 1 著者 Bon, C.G, Lee, J, Caveney, N.A, Strynadka, N.C.J. 登録日 2023-12-12 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216, 2024
8VBW	Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Ertapenem) inhibited form 分子名称: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Penicillin-binding protein 1 著者 Bon, C.G, Lee, J, Caveney, N.A, Strynadka, N.C.J. 登録日 2023-12-12 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216, 2024
8VBV	Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Cephalexin) inhibited form 分子名称: (2S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Penicillin-binding protein 1 著者 Bon, C.G, Lee, J, Caveney, N.A, Strynadka, N.C.J. 登録日 2023-12-12 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216, 2024
2J5U	MreC Lysteria monocytogenes 分子名称: MREC PROTEIN 著者 van den Ent, F, Leaver, M, Bendezu, F, Errington, J, de Boer, P, Lowe, J. 登録日 2006-09-19 公開日 2006-12-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Dimeric Structure of the Cell Shape Protein Mrec and its Functional Implications. Mol.Microbiol., 62, 2006
3ZFZ	Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by soaking 分子名称: CADMIUM ION, CHLORIDE ION, Ceftaroline, ... 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2012-12-13 公開日 2013-10-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110, 2013
4UG1	GpsB N-terminal domain 分子名称: CELL CYCLE PROTEIN GPSB, IMIDAZOLE, NICKEL (II) ION 著者 Rismondo, J, Cleverley, R.M, Lane, H.V, Grohennig, S, Steglich, A, Muller, L, Krishna Mannala, G, Hain, T, Lewis, R.J, Halbedel, S. 登録日 2015-03-20 公開日 2015-11-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of the Bacterial Cell Division Determinant Gpsb and its Interaction with Penicillin Binding Proteins. Mol.Microbiol., 99, 2016
4UG3	B. subtilis GpsB N-terminal Domain 分子名称: CELL CYCLE PROTEIN GPSB 著者 Rismondo, J, Cleverley, R.M, Lane, H.V, Grohennig, S, Steglich, A, Moller, L, Krishna Mannala, G, Hain, T, Lewis, R.J, Halbedel, S. 登録日 2015-03-21 公開日 2015-11-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the Bacterial Cell Division Determinant Gpsb and its Interaction with Penicillin Binding Proteins. Mol.Microbiol., 99, 2016
3ZG0	Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by cocrystallization 分子名称: CADMIUM ION, CHLORIDE ION, Ceftaroline, ... 著者 Otero, L.H, Rojas-Altuve, A, Hermoso, J.A. 登録日 2012-12-13 公開日 2013-10-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110, 2013

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