PDB: 47998 件ウェブページステータス検索Chemie searchBIRD

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3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) 分子名称: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... 著者 Ottmann, C, Weyand, M. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
7PWZ	Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228 分子名称: 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ... 著者 Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. 登録日 2021-10-07 公開日 2022-12-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. 登録日 2023-05-10 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
6FNC	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... 著者 Bier, D, Ottann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin 分子名称: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... 著者 Ottmann, C, Weyand, M. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
2O98	Structure of the 14-3-3 / H+-ATPase plant complex 分子名称: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ... 著者 Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. 登録日 2006-12-13 公開日 2007-04-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy Mol.Cell, 25, 2007
6FNB	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... 著者 Bier, D, Ottmann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
6FNA	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... 著者 Bier, D, Ottmann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
5MYC	Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS910 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. 登録日 2017-01-26 公開日 2017-03-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.459 Å) 主引用文献 Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
5MY9	Crystal structure of human 14-3-3 sigma in complex with LRRK2 peptide pS935 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Stevers, L.M, de Vries, R.M.J.M, Ottmann, C. 登録日 2017-01-26 公開日 2017-03-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.327 Å) 主引用文献 Structural interface between LRRK2 and 14-3-3 protein. Biochem. J., 474, 2017
6YOS	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide 分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor,Glucocorticoid receptor 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-15 公開日 2021-03-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6FN9	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, GLYCEROL, ... 著者 Bier, D, Ottmann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
2NPM	crystal structure of Cryptosporidium parvum 14-3-3 protein in complex with peptide 分子名称: 14-3-3 domain containing protein, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS 著者 Dong, A, Lew, J, Wasney, G, Ren, H, Lin, L, Hassanali, A, Qiu, W, Zhao, Y, Doyle, D, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) 登録日 2006-10-27 公開日 2006-11-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide 分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-14 公開日 2021-03-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide 分子名称: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-09 公開日 2021-03-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
4DAT	Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif II 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, Peptidylarginine Deiminase type VI 著者 Rose, R, Rose, M, Ottmann, C. 登録日 2012-01-13 公開日 2012-06-13 最終更新日 2012-10-24 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. J.Struct.Biol., 180, 2012
7BA7	Cys-42-tethered stabilizer 9 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-[3,5-bis(chloranyl)phenoxy]-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7BA5	Cys-42-tethered stabilizer 7 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(4-fluoranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7BA9	Cys-42-tethered stabilizer 11 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-methyl-2-(4-methylphenoxy)-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7BAA	Cys-42-tethered stabilizer 12 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(4-bromanyl-3-methoxy-phenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7BA8	Cys-42-tethered stabilizer 10 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-methyl-2-phenoxy-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7B9T	Cys-45-tethered stabilizer 5 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(4-chlorophenyl)sulfanyl-~{N}-(3-sulfanylpropyl)ethanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-14 公開日 2021-07-07 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7BA6	Cys-42-tethered stabilizer 8 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-[3,5-bis(fluoranyl)phenoxy]-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7BAB	Cys-42-tethered stabilizer 13 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-[2-chloranyl-4-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenoxy]-2-methyl-~{N}-(2-sulfanylethyl)propanamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-15 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021
7B9M	Cys-45-tethered stabilizer 3 of 14-3-3(sigma)/ERa PPI 分子名称: 14-3-3 protein sigma, 2-(2-cyanophenyl)sulfanyl-~{N}-(2-sulfanylethyl)benzamide, Estrogen receptor, ... 著者 Sijbesma, E, Ottmann, C. 登録日 2020-12-14 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Med.Chem.Lett., 12, 2021

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