PDB: 46308 件ウェブページステータス検索Chemie searchBIRD

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1O9F	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9D	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
6YO8	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 peptide 分子名称: 14-3-3 protein zeta/delta, Glucocorticoid receptor 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-14 公開日 2021-03-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
6YMO	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pS617 peptide 分子名称: 14-3-3 protein zeta/delta, 2-HYDROXYBENZOIC ACID, Glucocorticoid receptor, ... 著者 Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. 登録日 2020-04-09 公開日 2021-03-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
7QI1	Crystal structure of human 14-3-3 protein beta in complex with CFTR peptide pS753pS768 and PPI stabilizer CY007424 分子名称: 14-3-3 protein theta, ARGININE, Cystic fibrosis transmembrane conductance regulator, ... 著者 Stevers, L.M, Ottmann, C. 登録日 2021-12-14 公開日 2022-05-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR. Nat Commun, 13, 2022
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795 分子名称: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator 著者 Stevers, L.M, Leysen, S.F.R, Ottmann, C. 登録日 2015-08-06 公開日 2016-03-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein 分子名称: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... 著者 Ding, S, Shi, Z.B. 登録日 2015-04-18 公開日 2015-09-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
1O9E	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9C	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex 分子名称: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION 著者 Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. 登録日 2002-12-12 公開日 2003-03-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
5EXA	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, Fusicoccin A-THF derivative, ... 著者 Bier, D, Ottmann, C. 登録日 2015-11-23 公開日 2016-05-04 最終更新日 2018-12-19 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
5EWZ	Small-molecule stabilization of the 14-3-3/Gab2 PPI interface 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, GRB2-associated-binding protein 2 著者 Bier, D, Ottmann, C. 登録日 2015-11-23 公開日 2016-05-04 最終更新日 2018-12-19 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. Chemmedchem, 11, 2016
6F09	Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide 分子名称: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8 著者 Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S. 登録日 2017-11-17 公開日 2018-03-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Biophysical and structural insight into the USP8/14-3-3 interaction. FEBS Lett., 592, 2018
6BZD	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide 分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide 著者 Schumacher, M.A. 登録日 2017-12-22 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FNC	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... 著者 Bier, D, Ottann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
6FNB	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... 著者 Bier, D, Ottmann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
7AZ2	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1014 分子名称: 1-[4-methyl-2-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-14 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.081 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7AZ1	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1013 分子名称: 1-[4-methyl-3-(trifluoromethyl)phenyl]-2-phenyl-imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Ottmann, C. 登録日 2020-11-14 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
6FNA	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins 分子名称: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... 著者 Bier, D, Ottmann, C. 登録日 2018-02-02 公開日 2018-07-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
8CHF	cryo-EM Structure of Craf:14-3-3:Mek1 分子名称: 14-3-3 protein zeta isoform X1, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Dedden, D, Ulrich, G. 登録日 2023-02-07 公開日 2024-02-21 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (4.25 Å) 主引用文献 Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
8CPD	Cryo-EM structure of CRaf dimer with 14:3:3 分子名称: 14-3-3 protein zeta isoform X1, RAF proto-oncogene serine/threonine-protein kinase 著者 Dedden, D, Graedler, U, Schwarz, D, Thomsen, M, Leuthner, B, Schneider, E, Nitsche, J. 登録日 2023-03-02 公開日 2024-02-21 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes. J.Mol.Biol., 436, 2024
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. 分子名称: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION 著者 Hothorn, M, Obergfell, E. 登録日 2023-10-12 公開日 2023-10-25 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap 分子名称: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION 著者 Fiorillo, A, Ilari, A. 登録日 2015-05-08 公開日 2016-03-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
3IQU	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) 分子名称: 14-3-3 protein sigma, 6-mer from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... 著者 Ottmann, C, Weyand, M. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.05 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010
2O98	Structure of the 14-3-3 / H+-ATPase plant complex 分子名称: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ... 著者 Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. 登録日 2006-12-13 公開日 2007-04-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy Mol.Cell, 25, 2007
3IQV	Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin 分子名称: 14-3-3 protein sigma, 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... 著者 Ottmann, C, Weyand, M. 登録日 2009-08-21 公開日 2010-09-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol.Cell.Biol., 30, 2010

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