2O6D
 
 | | Structure of native rTp34 from Treponema pallidum | | 分子名称: | 1,2-ETHANEDIOL, 34 kDa membrane antigen, CHLORIDE ION, ... | | 著者 | Machius, M, Brautigam, C.A, Deka, R.K, Tomchick, D.R, Lumpkins, S.B, Norgard, M.V. | | 登録日 | 2006-12-07 | | 公開日 | 2006-12-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin.
J.Biol.Chem., 282, 2007
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6MWD
 | | NavAb Voltage-gated Sodium Channel, residues 1-239 with mutation T206S | | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ACETATE ION, ... | | 著者 | Lenaeus, M.J, Catterall, W.A. | | 登録日 | 2018-10-29 | | 公開日 | 2018-12-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.327 Å) | | 主引用文献 | Molecular dissection of multiphase inactivation of the bacterial sodium channel NaVAb.
J. Gen. Physiol., 151, 2019
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7KJR
 | | Cryo-EM structure of SARS-CoV-2 ORF3a | | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein | | 著者 | Kern, D.M, Hoel, C.M, Kotecha, A, Brohawn, S.G. | | 登録日 | 2020-10-26 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.08 Å) | | 主引用文献 | Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
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4Q6D
 | | Crystal structure of human carbonic anhydrase isozyme II with 4-[(Z)-azepan-1-yldiazenyl]benzenesulfonamide | | 分子名称: | 4-[(E)-azepan-1-yldiazenyl]benzenesulfonamide, BICINE, Carbonic anhydrase 2, ... | | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | | 登録日 | 2014-04-22 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | 4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases.
Molecules, 19, 2014
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3BVP
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7K21
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6FIF
 | | Crystal structure of the BRI1 Gly644-Asp (bri1-6) mutant from Arabidopsis thaliana. | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hothorn, M, Santiago, J, Hohmann, U. | | 登録日 | 2018-01-18 | | 公開日 | 2018-01-31 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4MBH
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1YXP
 | | HIV-1 DIS RNA subtype F- Zn soaked | | 分子名称: | 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3', ZINC ION | | 著者 | Ennifar, E, Dumas, P. | | 登録日 | 2005-02-22 | | 公開日 | 2006-01-31 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Polymorphism of Bulged-out Residues in HIV-1 RNA DIS Kissing Complex and Structure Comparison with Solution Studies.
J.Mol.Biol., 356, 2006
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6SHM
 | | An inactive (D136A and D137A) variant of alpha-1,6-mannanase, GH76A of Salegentibacter sp. HEL1_6 in complex with alpha-1,6-mannotetrose | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Mutant alpha-1,6-mannanase GH76A, ... | | 著者 | Hehemann, J.H, Solanki, V. | | 登録日 | 2019-08-07 | | 公開日 | 2020-09-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Glycoside hydrolase from the GH76 family indicates that marine Salegentibacter sp. Hel_I_6 consumes alpha-mannan from fungi.
Isme J, 2022
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3L6T
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7K41
 | | Bacterial O-GlcNAcase (OGA) with compound | | 分子名称: | 1,2-ETHANEDIOL, 4-(4-methylpiperidin-1-yl)-N-(2-phenylethyl)pyrimidin-2-amine, ACETATE ION, ... | | 著者 | Lane, W, Tjhen, R, Snell, G, Sang, B. | | 登録日 | 2020-09-14 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of a Novel and Brain-Penetrant O -GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.
J.Med.Chem., 64, 2021
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1NY0
 | | Crystal Structure of the complex between M182T mutant of TEM-1 and a boronic acid inhibitor (NBF) | | 分子名称: | Beta-lactamase TEM, PHOSPHATE ION, POTASSIUM ION, ... | | 著者 | Wang, X, Minasov, G, Blazquez, J, Caselli, E, Prati, F, Shoichet, B.K. | | 登録日 | 2003-02-11 | | 公開日 | 2003-08-26 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Recognition and Resistance in TEM beta-lactamase
Biochemistry, 42, 2003
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3KU3
 | | Crystal structure of a H2N2 influenza virus hemagglutinin, avian like | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Xu, R, Wilson, I.A. | | 登録日 | 2009-11-26 | | 公開日 | 2010-01-19 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic.
J.Virol., 84, 2010
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1X9H
 | | Crystal structure of phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum in complex with fructose 6-phosphate | | 分子名称: | FRUCTOSE -6-PHOSPHATE, GLYCEROL, SULFATE ION, ... | | 著者 | Swan, M.K, Hansen, T, Schoenheit, P, Davies, C. | | 登録日 | 2004-08-21 | | 公開日 | 2004-12-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.
Biochemistry, 43, 2004
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1RML
 | | NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-NAPHTHALENE TRISULPHONATE, 26 STRUCTURES | | 分子名称: | ACIDIC FIBROBLAST GROWTH FACTOR, NAPHTHALENE TRISULFONATE | | 著者 | Lozano, R.M, Jimenez, M.A, Santoro, J, Rico, M, Gimenez-Gallego, G. | | 登録日 | 1998-05-21 | | 公開日 | 1998-11-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of acidic fibroblast growth factor bound to 1,3, 6-naphthalenetrisulfonate: a minimal model for the anti-tumoral action of suramins and suradistas.
J.Mol.Biol., 281, 1998
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4KCB
 | | Crystal Structure of Exo-1,5-alpha-L-arabinanase from Bovine Ruminal Metagenomic Library | | 分子名称: | Arabinan endo-1,5-alpha-L-arabinosidase, PHOSPHATE ION | | 著者 | Santos, C.R, Polo, C.C, Costa, M.C.M.F, Nascimento, A.F.Z, Wong, D.W.S, Murakami, M.T. | | 登録日 | 2013-04-24 | | 公開日 | 2014-02-05 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Mechanistic strategies for catalysis adopted by evolutionary distinct family 43 arabinanases.
J.Biol.Chem., 289, 2014
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4HO0
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5HF9
 | | Crystal structure of human acetylcholinesterase in complex with paraoxon and HI6 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Franklin, M.F, Rudolph, M.J, Ginter, C, Cassidy, M.S, Cheung, J. | | 登録日 | 2016-01-06 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface.
Proteins, 84, 2016
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3B3F
 | | The 2.2 A crystal structure of the catalytic domain of coactivator-associated arginine methyl transferase I(CARM1,142-478), in complex with S-adenosyl homocysteine | | 分子名称: | Histone-arginine methyltransferase CARM1, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Troffer-Charlier, N, Cura, V, Hassenboehler, P, Moras, D, Cavarelli, J. | | 登録日 | 2007-10-22 | | 公開日 | 2007-11-06 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains.
Embo J., 26, 2007
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2W83
 | | Crystal structure of the ARF6 GTPase in complex with a specific effector, JIP4 | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ADP-RIBOSYLATION FACTOR 6, C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4, ... | | 著者 | Isabet, T, Montagnac, G, Regazzoni, K, Raynal, B, El Khadali, F, Franco, M, England, P, Chavrier, P, Houdusse, A, Menetrey, J. | | 登録日 | 2009-01-08 | | 公開日 | 2009-07-14 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | The Structural Basis of Arf Effector Specificity: The Crystal Structure of Arf6 in a Complex with Jip4.
Embo J., 28, 2009
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5SLA
 | | PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z1003207278 | | 分子名称: | 1-cyclohexyl-N-methylmethanesulfonamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ... | | 著者 | Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A. | | 登録日 | 2022-03-03 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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1HW4
 | | STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS | | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, THYMIDYLATE SYNTHASE | | 著者 | Phan, J, Steadman, J.D, Koli, S, Ding, W.C, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L. | | 登録日 | 2001-01-09 | | 公開日 | 2001-01-24 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
J.Biol.Chem., 276, 2001
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1ZKY
 | | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-3M and A Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide | | 分子名称: | 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, Estrogen receptor, Nuclear receptor coactivator 2 | | 著者 | Rajan, S.S, Hsieh, R.W, Sharma, S.K, Hahm, J.B, Nettles, K.W, Greene, G.L. | | 登録日 | 2005-05-04 | | 公開日 | 2006-05-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
J.Biol.Chem., 281, 2006
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4KIU
 | | Design and structural analysis of aromatic inhibitors of type II dehydroquinate dehydratase from Mycobacterium tuberculosis - compound 49d [5-[(3-nitrobenzyl)oxy]benzene-1,3-dicarboxylic acid] | | 分子名称: | 3-dehydroquinate dehydratase, 5-[(3-nitrobenzyl)oxy]benzene-1,3-dicarboxylic acid | | 著者 | Dias, M.V.B, Howard, N.G, Blundell, T.L, Abell, C. | | 登録日 | 2013-05-02 | | 公開日 | 2014-05-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Design and Structural Analysis of Aromatic Inhibitors of Type II Dehydroquinase from Mycobacterium tuberculosis.
Chemmedchem, 10, 2015
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