7KFN
| Structure of Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA containing a 2'-deoxy Benner's Base Z opposite the edited base | 分子名称: | Double-stranded RNA-specific editase 1, Gli1 1W5 23mer RNA, Gli1 8AZ 23mer RNA, ... | 著者 | Wilcox, X.E, Fisher, A.J, Beal, P.A. | 登録日 | 2020-10-14 | 公開日 | 2021-06-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J.Am.Chem.Soc., 143, 2021
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7KEF
| RNA polymerase II elongation complex with unnatural base dTPT3, rNaM in swing state | 分子名称: | (1S)-1,4-anhydro-1-(3-methoxynaphthalen-2-yl)-5-O-phosphono-D-ribitol, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | 著者 | Oh, J, Wang, D. | 登録日 | 2020-10-10 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.89 Å) | 主引用文献 | Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II. Nat.Chem.Biol., 17, 2021
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7KJS
| Crystal structure of CDK2/cyclin E in complex with PF-06873600 | 分子名称: | 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | 著者 | McTigue, M.A, He, Y, Ferre, R.A. | 登録日 | 2020-10-26 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.187 Å) | 主引用文献 | Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7L0J
| Structure of AMH bound to AMHR2-ECD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-Muellerian hormone type-2 receptor, Muellerian-inhibiting factor, ... | 著者 | Hart, K.N, Thompson, T.B. | 登録日 | 2020-12-11 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family. Proc.Natl.Acad.Sci.USA, 118, 2021
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7L6X
| Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to GNE-371 | 分子名称: | 1,2-ETHANEDIOL, 6-(but-3-en-1-yl)-4-[1-methyl-6-(morpholine-4-carbonyl)-1H-benzimidazol-4-yl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one, Transcription initiation factor TFIID subunit 1 | 著者 | Karim, M.R, Schonbrunn, E. | 登録日 | 2020-12-24 | 公開日 | 2021-06-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
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7L4Z
| Structure of SARS-CoV-2 spike RBD in complex with cyclic peptide | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-DTY-LYS-ALA-GLY-VAL-VAL-TYR-GLY-TYR-ASN-ALA-TRP-ILE-ARG-CYS-NH2, Spike protein S1 | 著者 | Christie, M, Mackay, J.P, Passioura, T, Payne, R.J. | 登録日 | 2020-12-21 | 公開日 | 2021-06-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.96 Å) | 主引用文献 | Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display. Acs Cent.Sci., 7, 2021
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7KEE
| RNA polymerase II elongation complex with unnatural base dTPT3, rNaMTP bound to E-site | 分子名称: | (1S)-1,4-anhydro-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-1-(3-methoxynaphthalen-2-yl)-D-ribitol, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | 著者 | Oh, J, Wang, D. | 登録日 | 2020-10-10 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II. Nat.Chem.Biol., 17, 2021
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7KIL
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7KIH
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7KIQ
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7KRI
| FR6-bound SARS-CoV-2 Nsp9 RNA-replicase | 分子名称: | 1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione, MALONATE ION, Non-structural protein 9, ... | 著者 | Littler, D.R, Gully, B.S, Rossjohn, J. | 登録日 | 2020-11-20 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9. J.Biol.Chem., 297, 2021
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7L1W
| Unlocking the structural features for the exo-xylobiosidase activity of an unusual GH11 member identified in a compost-derived consortium | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Exo-B-1,4-beta-xylanase | 著者 | Kadowaki, M.A.S, Polikarpov, I, Briganti, L, Evangelista, D.E. | 登録日 | 2020-12-15 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Unlocking the structural features for the xylobiohydrolase activity of an unusual GH11 member identified in a compost-derived consortium. Biotechnol.Bioeng., 118, 2021
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7L1Y
| Unlocking the structural features for the exo-xylobiosidase activity of an unusual GH11 member identified in a compost-derived consortium-xylobiose complex | 分子名称: | 1,2-ETHANEDIOL, Exo-B-1,4-beta-xylanase, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose | 著者 | Kadowaki, M.A.S, Polikarpov, I, Briganti, L, Evangelista, D.E. | 登録日 | 2020-12-15 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Unlocking the structural features for the xylobiohydrolase activity of an unusual GH11 member identified in a compost-derived consortium. Biotechnol.Bioeng., 118, 2021
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7KPR
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7L1Z
| Unlocking the structural features for the exo-xylobiosidase activity of an unusual GH11 member identified in a compost-derived consortium - NT-truncated form | 分子名称: | 1,2-ETHANEDIOL, Exo-B-1,4-beta-xylanase, SULFATE ION | 著者 | Kadowaki, M.A.S, Polikarpov, I, Briganti, L, Evangelista, D.E. | 登録日 | 2020-12-15 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Unlocking the structural features for the xylobiohydrolase activity of an unusual GH11 member identified in a compost-derived consortium. Biotechnol.Bioeng., 118, 2021
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7L16
| Crystal structure of sugar-bound melibiose permease MelB | 分子名称: | Melibiose carrier protein, dodecyl 6-O-alpha-D-galactopyranosyl-beta-D-glucopyranoside | 著者 | Guan, L. | 登録日 | 2020-12-14 | 公開日 | 2021-08-04 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB. Commun Biol, 4, 2021
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7L4C
| Crystal structure of the DRM2-CTT DNA complex | 分子名称: | DNA (5'-D(*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*TP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | 著者 | Fang, J, Song, J. | 登録日 | 2020-12-18 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
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7L4H
| Crystal structure of the DRM2-CTG DNA complex | 分子名称: | DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*TP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*AP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | 著者 | Fang, J, Song, J. | 登録日 | 2020-12-19 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
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7L4K
| Crystal structure of the DRM2-CCG DNA complex | 分子名称: | DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*CP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*GP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | 著者 | Fang, J, Song, J. | 登録日 | 2020-12-19 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv, 7, 2021
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7KKR
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7KKA
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7L4I
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7KK8
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7KKB
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7L4J
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