PDB: 37932 件ウェブページステータス検索Chemie searchBIRD

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8PK8	Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (persulfide on ISCU2) 分子名称: Acyl carrier protein, Cysteine desulfurase, FE (II) ION, ... 著者 Steinhilper, R, Murphy, B.J. 登録日 2023-06-26 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2. Nat Commun, 15, 2024
7QFZ	BrxR, a WYL-domain containing transcriptional regulator 分子名称: SULFATE ION, WYL domain-containing protein 著者 Picton, D.M, Blower, T.R. 登録日 2021-12-07 公開日 2022-05-18 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands. Nucleic Acids Res., 50, 2022
8PK9	Structure of the human mitochondrial iron-sulfur cluster biosynthesis complex during persulfide transfer (persulfide on NFS1 and ISCU2) 分子名称: Acyl carrier protein, Cysteine desulfurase, FE (II) ION, ... 著者 Steinhilper, R, Murphy, B.J. 登録日 2023-06-26 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.58 Å) 主引用文献 Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2. Nat Commun, 15, 2024
7LGO	Crystal structure of the nucleic acid binding domain (NAB) of Nsp3 from SARS-CoV-2 分子名称: Non-structural protein 3 著者 Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2021-01-20 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structure of the nucleic acid binding domain (NAB) of Nsp3 from SARS-CoV-2 To Be Published
7QHM	Cytochrome bcc-aa3 supercomplex (respiratory supercomplex III2/IV2) from Corynebacterium glutamicum (stigmatellin and azide bound) 分子名称: (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, AZIDE ION, ... 著者 Kao, W.-C, Hunte, C. 登録日 2021-12-13 公開日 2022-05-18 最終更新日 2024-10-09 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis for safe and efficient energy conversion in a respiratory supercomplex. Nat Commun, 13, 2022
7L9R	Crystal Structure of a putative deoxyhypusine synthase from Entamoeba histolytica 分子名称: CHLORIDE ION, Deoxyhypusine synthase, putative 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-01-04 公開日 2021-02-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of a putative deoxyhypusine synthase from Entamoeba histolytica to be published
8CTI	Cryo-EM structure of human METTL1-WDR4-tRNA(Val) complex 分子名称: tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, tRNA-Val-TAC-2-1 著者 Li, J, Wang, L, Fontana, P, Hunkeler, M, Roy-Burman, S.S, Wu, H, Fischer, E.S, Gregory, R.I. 登録日 2022-05-14 公開日 2022-12-07 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature, 613, 2023
7LHJ	Crystal structure of Q108K:K40L:T51V:T53C:R58W:T29L:Y19W:Q4A mutant of cellular retinol binding protein II complex with 15-cis-retinal 分子名称: ACETATE ION, GLYCEROL, RETINAL, ... 著者 Ehyaei, N, Geiger, J.H, Borhan, B. 登録日 2021-01-25 公開日 2021-02-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Crystal structure of Q108K:K40L:T51V:T53C:R58W:T29L:Y19W:Q4A mutant of cellular retinol binding protein II complex with 15cis- retinal To Be Published
8DG1	Crystal Structure of EcDsbA in a complex with DMSO 分子名称: COPPER (II) ION, DIMETHYL SULFOXIDE, Thiol:disulfide interchange protein DsbA 著者 Whitehouse, R.L, Ilyichova, O.V, Taylor, A.J. 登録日 2022-06-23 公開日 2022-12-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores. Rsc Med Chem, 14, 2023
6UGQ	Human Carbonic Anhydrase IX-mimic complexed with SB4-206 分子名称: 5-chloro-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione, Carbonic anhydrase IX-mimic, ZINC ION 著者 Murray, A.B, Lomelino, C.L, McKenna, R. 登録日 2019-09-26 公開日 2019-12-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.305 Å) 主引用文献 "A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. J.Med.Chem., 63, 2020
7LD8	Crystal Structure of Putative non-heme bromoperoxidase BpoC from Mycobacterium tuberculosis H37Rv 分子名称: 1,2-ETHANEDIOL, Putative non-heme bromoperoxidase BpoC, SODIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-01-12 公開日 2021-01-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal Structure of Putative non-heme bromoperoxidase BpoC from Mycobacterium tuberculosis H37Rv to be published
7LDB	G150A Pseudomonas fluorescens isocyanide hydratase (G150A-3) at 274K, Phenix-refined 分子名称: Isonitrile hydratase InhA 著者 Su, Z, Dasgupta, M, Yoon, C.H, Wilson, M.A. 登録日 2021-01-13 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Reproducibility of protein x-ray diffuse scattering and potential utility for modeling atomic displacement parameters. Struct Dyn., 8, 2021
8CXE	Crystal Structure of EcDsbA in a complex with 1H-imidazole 分子名称: IMIDAZOLE, Thiol:disulfide interchange protein DsbA 著者 Whitehouse, R.L, Ilyichova, O.V, Taylor, A.J. 登録日 2022-05-20 公開日 2022-12-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores. Rsc Med Chem, 14, 2023
8D10	Crystal Structure of EcDsbA in a complex with (1-methyl-1H-pyrazol-5-yl)methanamine 分子名称: 1-(1-methyl-1H-pyrazol-5-yl)methanamine, COPPER (II) ION, Thiol:disulfide interchange protein DsbA 著者 Whitehouse, R.L, Ilyichova, O.V, Taylor, A.J. 登録日 2022-05-26 公開日 2022-12-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores. Rsc Med Chem, 14, 2023
8DG2	Crystal Structure of EcDsbA in a complex with DMSO 分子名称: COPPER (II) ION, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Whitehouse, R.L, Ilyichova, O.V, Taylor, A.J. 登録日 2022-06-23 公開日 2022-12-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores. Rsc Med Chem, 14, 2023
7L9U	Crystal Structure of S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis in complex with a 12-mer PEG 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DODECAETHYLENE GLYCOL, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-01-05 公開日 2021-02-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal Structure of S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis in complex with a 12-mer PEG to be published
6UFC	Carbonic anhydrase 2 with inhibitor (2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-N-(4-sulfamoylphenyl)butanamide (11d/D4) 分子名称: (2Z)-2-[(4-methoxyphenyl)methylidene]-3-oxo-N-(4-sulfamoylphenyl)butanamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Peat, T.S. 登録日 2019-09-24 公開日 2020-08-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.325 Å) 主引用文献 Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. J.Med.Chem., 63, 2020
8DAL	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinonitrile 分子名称: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carbonitrile, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-06-13 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
7CNC	cystal structure of human ERH in complex with DGCR8 分子名称: Enhancer of rudimentary homolog, Microprocessor complex subunit DGCR8 著者 Li, F, Shen, S. 登録日 2020-07-30 公開日 2020-10-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8. Nucleic Acids Res., 48, 2020
8DDB	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 4-(benzyloxy)-6-bromo-3-hydroxypicolinic acid 分子名称: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-06-17 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
8DJY	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-Bromo-2-(4,5-dihydro-1H-imidazol-2-yl)-3-hydroxypyridin-4(1H)-one 分子名称: (2M)-6-bromo-2-(4,5-dihydro-1H-imidazol-2-yl)-3-hydroxypyridin-4(1H)-one, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-07-01 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
8FN0	CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator 分子名称: 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. 登録日 2022-12-26 公開日 2023-03-29 最終更新日 2023-04-19 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry, 62, 2023
8D11	Crystal Structure of EcDsbA in a complex with 1-methyl-1H-pyrazol-5-amine 分子名称: 1-methyl-1H-pyrazol-5-amine, COPPER (II) ION, Thiol:disulfide interchange protein DsbA 著者 Whitehouse, R.L, Ilyichova, O.V, Taylor, A.J. 登録日 2022-05-26 公開日 2022-12-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores. Rsc Med Chem, 14, 2023
8CS7	[CCG/CCG] Self-Assembled 3D DNA Hexagonal Tensegrity Triangle 分子名称: DNA (5'-D(*CP*CP*GP*CP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), DNA (5'-D(*CP*CP*GP*TP*GP*AP*TP*GP*T)-3'), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), ... 著者 Lu, B, Vecchioni, S, Ohayon, Y.P, Seeman, N.C, Mao, C, Sha, R. 登録日 2022-05-12 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (6.67 Å) 主引用文献 Programmable 3D Hexagonal Geometry of DNA Tensegrity Triangles. Angew.Chem.Int.Ed.Engl., 62, 2023
8PK2	Cryo EM structure of the type 1m polymorph of alpha-synuclein 分子名称: Alpha-synuclein 著者 Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. 登録日 2023-06-24 公開日 2024-05-29 最終更新日 2024-09-11 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation. Elife, 12, 2024

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