PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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7JH2	CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C IN COMPLEX WITH A POTENT, SELECTIVE AND ORALLY BIOAVAILABLE ROR-GAMMA-T INVERSE AGONIST 分子名称: 2-({[2-(4-{(3R)-1-(4-acetylpiperazine-1-carbonyl)-3-[(4-fluorophenyl)sulfonyl]pyrrolidin-3-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-yl]oxy}methyl)-3-fluorobenzonitrile, Nuclear receptor ROR-gamma, SULFATE ION 著者 Sack, J.S. 登録日 2020-07-20 公開日 2020-08-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.367 Å) 主引用文献 Discovery of 2,6-difluorobenzyl ether series of phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfones as surprisingly potent, selective and orally bioavailable ROR gamma t inverse agonists. Bioorg.Med.Chem.Lett., 30, 2020
2FOF	Structure of porcine pancreatic elastase in 80% isopropanol 分子名称: CALCIUM ION, ISOPROPYL ALCOHOL, SULFATE ION, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
2BJW	PspF AAA domain 分子名称: PSP OPERON TRANSCRIPTIONAL ACTIVATOR 著者 Rappas, M, Schumacher, J, Beuron, F, Niwa, H, Bordes, P, Wigneshweraraj, S, Keetch, C.A, Robinson, C.V, Buck, M, Zhang, X. 登録日 2005-02-08 公開日 2005-03-31 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Insights Into the Activity of Enhancer-Binding Proteins Science, 307, 2005
2FWO	MHC Class I H-2Kd heavy chain in complex with beta-2microglobulin and peptide derived from influenza nucleoprotein 分子名称: Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ... 著者 Mitaksov, V, Fremont, D.H. 登録日 2006-02-02 公開日 2006-02-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Definition of the H-2Kd Peptide-binding Motif. J.Biol.Chem., 281, 2006
2FOB	Structure of porcine pancreatic elastase in 40/50/10 cyclohexane 分子名称: CALCIUM ION, ISOPROPYL ALCOHOL, SULFATE ION, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
3VIB	Structural basis for multidrug recognition and antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, MtrR, PHOSPHATE ION 著者 Kumaraswami, M, Shafer, W.M, Brennan, R.G. 登録日 2011-09-27 公開日 2012-10-03 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for multidrug recognitionand antimicrobial resistance by MTRR, an efflux pump regulator from Neisseria Gonorrhoeae TO BE PUBLISHED
7KPX	Structure of the yeast CKM 分子名称: Mediator of RNA polymerase II transcription subunit 12, Mediator of RNA polymerase II transcription subunit 13, Meiotic mRNA stability protein kinase SSN3, ... 著者 Li, Y.C, Chao, T.C, Kim, H.J, Cholko, T, Chen, S.F, Nakanishi, K, Chang, C.E, Murakami, K, Garcia, B.A, Boyer, T.G, Tsai, K.L. 登録日 2020-11-12 公開日 2021-01-27 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Sci Adv, 7, 2021
1PRG	LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 分子名称: PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA) 著者 Nolte, R.T, Wisely, G.B, Milburn, M.V. 登録日 1998-07-02 公開日 2001-01-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature, 395, 1998
2BJV	Crystal Structure of PspF(1-275) R168A mutant 分子名称: PSP OPERON TRANSCRIPTIONAL ACTIVATOR 著者 Rappas, M, Schumacher, J, Beuron, F, Niwa, H, Bordes, P, Wigneshweraraj, S, Keetch, C.A, Robinson, C.V, Buck, M, Zhang, X. 登録日 2005-02-08 公開日 2005-03-31 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Insights Into the Activity of Enhancer-Binding Proteins Science, 307, 2005
2FOA	Structure of porcine pancreatic elastase in 40/50/10 % benzene 分子名称: CALCIUM ION, ISOPROPYL ALCOHOL, SULFATE ION, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
2FO9	Structure of porcine pancreatic elastase in 95% acetone 分子名称: ACETONE, CALCIUM ION, SULFATE ION, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
2FOH	Structure of porcine pancreatic elastase in 40% trifluoroethanol 分子名称: CALCIUM ION, SULFATE ION, TRIFLUOROETHANOL, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
3MH0	Mutagenesis of p38 MAP Kinase eshtablishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-07 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry, 46, 2007
2FZ2	Structure of Turnip Yellow Mosaic Virus at 100 K 分子名称: 5'-R(*CP*CP*C)-3', Coat protein 著者 Larson, S.B, Lucas, R.W, McPherson, A. 登録日 2006-02-08 公開日 2006-02-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The RNA of turnip yellow mosaic virus exhibits icosahedral order. Virology, 334, 2005
6M95	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1 分子名称: (4-benzylpiperidin-1-yl)[2-methoxy-4-(methylsulfanyl)phenyl]methanone, Mitogen-activated protein kinase 14 著者 Lane, W, Okada, K. 登録日 2018-08-22 公開日 2019-04-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1. Chemmedchem, 14, 2019
4N8R	Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 分子名称: 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha 著者 Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. 登録日 2013-10-17 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
2FZ1	Structure of Empty Head Turnip Yellow Mosaic Virus (ATC) at 100 K 分子名称: Coat protein 著者 Larson, S.B, Lucas, R.W, McPherson, A. 登録日 2006-02-08 公開日 2006-02-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The RNA of turnip yellow mosaic virus exhibits icosahedral order. Virology, 334, 2005
2FZF	Hypothetical Protein Pfu-1136390-001 From Pyrococcus furiosus 分子名称: hypothetical protein 著者 Fu, Z.-Q, Liu, Z.-J, Lee, D, Kelley, L, Chen, L, Tempel, W, Shah, N, Horanyi, P, Lee, H.S, Habel, J, Dillard, B.D, Nguyen, D, Chang, S.-H, Zhang, H, Chang, J, Sugar, F.J, Poole, F.L, Jenney Jr, F.E, Adams, M.W.W, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) 登録日 2006-02-09 公開日 2006-02-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Hypothetical Protein Pfu-1136390-001 From Pyrococcus furiosus To be published
7K7V	The X-ray crystal structure of SSR4, an S. pombe chromatin remodelling protein: iodide derivative 分子名称: CHLORIDE ION, GLYCEROL, IODIDE ION, ... 著者 Peat, T.S, Newman, J. 登録日 2020-09-24 公開日 2020-12-16 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.882 Å) 主引用文献 The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein. Acta Crystallogr.,Sect.F, 76, 2020
2FOG	Structure of porcine pancreatic elastase in 40% trifluoroethanol 分子名称: CALCIUM ION, SULFATE ION, TRIFLUOROETHANOL, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
2FOD	Structure of porcine pancreatic elastase in 80% ethanol 分子名称: CALCIUM ION, ETHANOL, SULFATE ION, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
2FOE	Structure of porcine pancreatic elastase in 80% hexane 分子名称: (2S)-HEX-5-ENE-1,2-DIOL, CALCIUM ION, SULFATE ION, ... 著者 Mattos, C, Bellamacina, C.R, Peisach, E, Pereira, A, Vitkup, D, Petsko, G.A, Ringe, D. 登録日 2006-01-13 公開日 2006-04-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Multiple solvent crystal structures: Probing binding sites, plasticity and hydration J.Mol.Biol., 357, 2006
7JTM	CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244-487)-L6-SRC1(6T78-692) IN COMPLEX WITH A TRICYCLIC SULFONE RORGT INVERSE AGONIST 分子名称: Nuclear receptor ROR-gamma, trans-4-[(3aR,9bR)-8-cyano-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl]cyclohexane-1-carboxylic acid 著者 Sack, J.S. 登録日 2020-08-18 公開日 2020-09-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Tricyclic sulfones as potent, selective and efficacious ROR gamma t inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization. Bioorg.Med.Chem.Lett., 30, 2020
2G00	Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide 分子名称: 3-[6-{2'-[(DIMETHYLAMINO)METHYL]BIPHENYL-4-YL}-7-OXO-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDIN-1-YL]BENZAMIDE, Coagulation factor X 著者 Alexander, R.S. 登録日 2006-02-10 公開日 2006-10-03 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties. Bioorg.Med.Chem.Lett., 16, 2006
2G1K	Crystal structure of Mycobacterium tuberculosis shikimate kinase in complex with shikimate at 1.75 angstrom resolution 分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, CHLORIDE ION, SULFATE ION, ... 著者 Gan, J, Gu, Y, Li, Y, Yan, H, Ji, X. 登録日 2006-02-14 公開日 2006-07-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of Mycobacterium tuberculosis Shikimate Kinase in Complex with Shikimic Acid and an ATP Analogue. Biochemistry, 45, 2006

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