9NLE
 
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6Y2L
 | | Structure of human ribosome in POST state | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... | | 著者 | Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A. | | 登録日 | 2020-02-16 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes.
Cell Rep, 31, 2020
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7PWO
 | | Cryo-EM structure of Giardia lamblia ribosome at 2.75 A resolution | | 分子名称: | 40S ribosomal protein S21, 40S ribosomal protein S26, 40S ribosomal protein S30, ... | | 著者 | Hiregange, D.G, Rivalta, A, Bose, T, Breiner-Goldstein, E, Samiya, S, Cimicata, G, Kulakova, L, Zimmerman, E, Bashan, A, Herzberg, O, Yonath, A. | | 登録日 | 2021-10-07 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Nucleic Acids Res., 50, 2022
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8UVR
 | | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Killam, B.Y, Phelps, G.A, Lee, R.E, Polikanov, Y.S. | | 登録日 | 2023-11-03 | | 公開日 | 2024-08-07 | | 最終更新日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8UVS
 | | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution | | 分子名称: | (2R,4R,4aS,5aR,6S,7S,8R,9S,9aR,10aS)-2-methyl-6,8-bis(methylamino)-4-({[2-(oxan-4-yl)ethyl]amino}methyl)octahydro-2H-pyrano[2,3-b][1,4]benzodioxine-4,4a,7,9(10aH)-tetrol, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | 著者 | Killam, B.Y, Phelps, G.A, Lee, R.E, Polikanov, Y.S. | | 登録日 | 2023-11-03 | | 公開日 | 2024-08-07 | | 最終更新日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8QOI
 | | Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical modifications and ions in RNA | | 分子名称: | 18S rRNA (1740-MER), 28S rRNA (3773-MER), 40S ribosomal protein S10, ... | | 著者 | Holvec, S, Barchet, C, Frechin, L, Hazemann, I, von Loeffelholz, O, Klaholz, B.P. | | 登録日 | 2023-09-29 | | 公開日 | 2024-06-12 | | 最終更新日 | 2024-08-28 | | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | | 主引用文献 | The structure of the human 80S ribosome at 1.9 angstrom resolution reveals the molecular role of chemical modifications and ions in RNA.
Nat.Struct.Mol.Biol., 31, 2024
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8P2K
 | | Ternary complex of translating ribosome, NAC and METAP1 | | 分子名称: | 18s rRNA, 28S rRNA, 40S ribosomal protein S11, ... | | 著者 | Jia, M, Jaskolowski, M, Scaiola, A, Jomaa, A, Ban, N. | | 登録日 | 2023-05-16 | | 公開日 | 2023-07-19 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | NAC controls cotranslational N-terminal methionine excision in eukaryotes.
Science, 380, 2023
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9G8M
 | | human 80S ribosome bound by a SKI2-exosome complex | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Koegel, A, Keidel, A, Loukeri, M.J, Kuhn, C.C, Langer, L.M, Schaefer, I.B, Conti, E. | | 登録日 | 2024-07-23 | | 公開日 | 2024-10-23 | | 最終更新日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of mRNA decay by the human exosome-ribosome supercomplex.
Nature, 635, 2024
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9D7S
 | | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Aleksandrova, E.V, Huang, W, Baliga, C, Atkinson, G.C, Vazquez-Laslop, N, Mankin, A.S, Polikanov, Y.S. | | 登録日 | 2024-08-17 | | 公開日 | 2024-11-13 | | 最終更新日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects.
Embo Rep., 25, 2024
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9D7T
 | | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution | | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Aleksandrova, E.V, Huang, W, Baliga, C, Atkinson, G.C, Vazquez-Laslop, N, Mankin, A.S, Polikanov, Y.S. | | 登録日 | 2024-08-17 | | 公開日 | 2024-11-13 | | 最終更新日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects.
Embo Rep., 25, 2024
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9C3H
 | | Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site. | | 分子名称: | 18S rRNA, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 28S rRNA, ... | | 著者 | Erzberger, J.P, Cruz, V.E. | | 登録日 | 2024-06-01 | | 公開日 | 2024-12-04 | | 実験手法 | ELECTRON MICROSCOPY (2 Å) | | 主引用文献 | Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes.
Science, 386, 2024
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9D0J
 | | Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution | | 分子名称: | (4S,5aS,8S,8aR)-N-[(1R,4R,6Z,8R,9R,10R,11R,12S,13R)-4-fluoro-11,12,13-trihydroxy-8-methyl-14-oxa-2-thiabicyclo[8.3.1]tetradec-6-en-9-yl]-4-(2-methylpropyl)octahydro-2H-oxepino[2,3-c]pyrrole-8-carboxamide (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | 著者 | Aleksandrova, E.V, Tresco, B.I.C, Wu, K.J.Y, Ramkissoon, A, Purdy, M, See, D.N.Y, Liu, R.Y, Myers, A.G, Polikanov, Y.S. | | 登録日 | 2024-08-07 | | 公開日 | 2024-11-20 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of a fluorinated macrobicyclic antibiotic through chemical synthesis.
Nat.Chem., 17, 2025
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8JDJ
 | | Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU) | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2023-05-14 | | 公開日 | 2023-12-06 | | 最終更新日 | 2025-02-12 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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8JDM
 | | Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state) | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2023-05-14 | | 公開日 | 2023-12-06 | | 最終更新日 | 2025-02-12 | | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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8JDK
 | | Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2023-05-14 | | 公開日 | 2023-12-06 | | 最終更新日 | 2025-02-12 | | 実験手法 | ELECTRON MICROSCOPY (2.26 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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8G60
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8JDL
 | | Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state) | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2023-05-14 | | 公開日 | 2023-12-06 | | 最終更新日 | 2025-02-12 | | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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8G5Y
 | | mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state) | | 分子名称: | 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... | | 著者 | Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. | | 登録日 | 2023-02-14 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | | 主引用文献 | mRNA decoding in human is kinetically and structurally distinct from bacteria.
Nature, 617, 2023
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8UKB
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8UIY
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8UIK
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8UJB
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8UJJ
 | | In situ HHT and CHX treated A-P state 80S ribosome | | 分子名称: | (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA, 28S rRNA, ... | | 著者 | Wei, Z, Yong, X. | | 登録日 | 2023-10-11 | | 公開日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | In situ HHT and CHX treated human A-P state 80S ribosome
To Be Published
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8UIZ
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8UJK
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