PDB: 1328 件ウェブページステータス検索Chemie searchBIRD

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4Q02	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 3,4-difluorobenzenethiol, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4Q21	MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kim, S.-H. 登録日 1991-09-25 公開日 1992-07-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 1990
4QL3	Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2014-06-10 公開日 2015-06-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.041 Å) 主引用文献 Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13, 2015
4RKF	Drosophila melanogaster Rab3 bound to GMPPNP 分子名称: MAGNESIUM ION, PENTAETHYLENE GLYCOL, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Lardong, J.A, Driller, J.H, Depner, H, Weise, C, Petzoldt, A, Wahl, M.C, Sigrist, S.J, Loll, B. 登録日 2014-10-13 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun, 71, 2015
5XR7	Crystal structure of RabA1a (Q72K) in complex with GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein RABA1a 著者 Yun, J.S, Chang, J.H. 登録日 2017-06-07 公開日 2018-06-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana To Be Published
5XCO	Crystal structure of human K-Ras G12D Mutant in complex with GDP and Cyclic Inhibitory Peptide 分子名称: 1,2-ETHANEDIOL, ACE-ARG-ARG-ARG-ARG-CYS-PRO-LEU-TYR-ILE-SER-TYR-ASP-PRO-VAL-CYS-ARG-ARG-ARG-ARG-NH2, GTPase KRas, ... 著者 Sogabe, S, Miwa, M. 登録日 2017-03-23 公開日 2017-05-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d ACS Med Chem Lett, 8, 2017
5XC3	Crystal structure of Acanthamoeba polyphaga mimivirus Rab GTPase in complex with GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Probable Rab-related GTPase 著者 Ku, B, You, J.A, Kim, S.J. 登録日 2017-03-22 公開日 2017-10-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.497 Å) 主引用文献 Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase Arch. Virol., 162, 2017
1IOZ	Crystal Structure of the C-HA-RAS Protein Prepared by the Cell-Free Synthesis 分子名称: GUANOSINE-5'-DIPHOSPHATE, TRANSFORMING PROTEIN P21/H-RAS-1 著者 Kigawa, T, Yamaguchi-Nunokawa, E, Kodama, K, Matsuda, T, Yabuki, T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2001-04-18 公開日 2001-10-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Selenomethionine incorporation into a protein by cell-free synthesis J.STRUCT.FUNCT.GENOM., 2, 2001
5XR6	Crystal structure of RabA1a in complex with GppNHp 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein RABA1a 著者 Yun, J.S, Chang, J.H. 登録日 2017-06-07 公開日 2018-06-13 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure and subcellular localization of RabA1a from Arabidopsis thaliana To Be Published
1JAH	H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM 分子名称: C-HA-RAS, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Schweins, T, Scheffzek, K, Assheuer, R, Wittinghofer, A. 登録日 1996-12-15 公開日 1997-07-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. J.Mol.Biol., 266, 1997
1KMQ	Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L) 分子名称: 1,4-DIETHYLENE DIOXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Longenecker, K, Read, P, Lin, S.-K, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S. 登録日 2001-12-17 公開日 2003-05-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution. Acta Crystallogr.,Sect.D, 59, 2003
5YOZ	Solution structure of truncated Rab5a from Leishmania donovani 分子名称: Rab5a 著者 Maheshwari, D, Yadav, R, Mukhopadhyay, A, Arora, A. 登録日 2017-10-31 公開日 2018-10-24 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural and Biophysical Characterization of Rab5a from Leishmania Donovani Biophys. J., 115, 2018
4GZL	Crystal structure of RAC1 Q61L mutant 分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Ha, B.H, Boggon, T.J. 登録日 2012-09-06 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc.Natl.Acad.Sci.USA, 110, 2013
5YXZ	Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI484 分子名称: 1,2-ETHANEDIOL, 1-[4-[6-chloranyl-8-fluoranyl-7-(2-fluorophenyl)quinazolin-4-yl]piperazin-1-yl]propan-1-one, GTPase KRas, ... 著者 Swaminathan, S, Thakur, M.K, Kandan, S, Gautam, A, Kanavalli, M, Simhadri, P, Gosu, R. 登録日 2017-12-07 公開日 2018-04-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI484 To Be Published
5YY1	Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI739 分子名称: 1,2-ETHANEDIOL, 1-[4-[6-chloranyl-8-fluoranyl-7-[2-(trifluoromethyl)phenyl]quinazolin-4-yl]piperazin-1-yl]propan-1-one, GTPase KRas, ... 著者 Swaminathan, S, Thakur, M.K, Kandan, S, Gautam, A, Kanavalli, M, Simhadri, P, Gosu, R. 登録日 2017-12-07 公開日 2018-04-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Co-crystal Structure of KRAS (G12C) covalently bound with Quinazoline based inhibitor JBI739 To Be Published
1K8R	Crystal structure of Ras-Bry2RBD complex 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein kinase byr2, ... 著者 Scheffzek, K, Gruenewald, P, Wohlgemuth, S, Kabsch, W, Tu, H, Wigler, M, Wittinghofer, A, Herrmann, C. 登録日 2001-10-25 公開日 2002-03-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure, 9, 2001
5YXH	Structure of Rheb-GDP 分子名称: GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Mahoney, S.J. 登録日 2017-12-05 公開日 2018-02-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun, 9, 2018
5ZC6	Solution structure of H-RasT35S mutant protein in complex with KBFM123 分子名称: 3-oxidanyl-~{N}-[[(2~{R})-oxolan-2-yl]methyl]naphthalene-2-carboxamide, GTPase HRas, MAGNESIUM ION, ... 著者 Matsumoto, S, Hayashi, Y, Hiraga, T, Matsuo, K, Kataoka, T. 登録日 2018-02-15 公開日 2018-09-12 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring Biochemistry, 57, 2018
1KY2	GPPNHP-BOUND YPT7P AT 1.6 A RESOLUTION 分子名称: GTP-BINDING PROTEIN YPT7P, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Constantinescu, A.-T, Rak, A, Scheidig, A.J. 登録日 2002-02-02 公開日 2002-06-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. Structure, 10, 2002
1KAO	CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAP2A WITH GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAP2A 著者 Cherfils, J, Menetrey, J, Le Bras, G. 登録日 1997-08-01 公開日 1997-12-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. EMBO J., 16, 1997
5ZVP	Aspergillus fumigatus Rho1 F25N 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho GTPase Rho1, ... 著者 Wei, W.F, Van Aalten, D.M.F. 登録日 2018-05-12 公開日 2019-05-15 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Aspergillus fumigateurs Rho1 F25N To Be Published
1LF5	Crystal Structure of RasA59G in the GDP-bound Form 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein P21/H-RAS-1 著者 Hall, B.E, Bar-Sagi, D, Nassar, N. 登録日 2002-04-10 公開日 2002-11-06 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The Structural Basis for the Transition from Ras-GTP to Ras-GDP Proc.Natl.Acad.Sci.USA, 99, 2002
1IAQ	C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, TRANSFORMING PROTEIN P21/H-RAS-1 著者 Spoerner, M, Herrmann, C, Vetter, I.R, Kalbitzer, H.R, Wittinghofer, A. 登録日 2001-03-23 公開日 2001-06-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc.Natl.Acad.Sci.USA, 98, 2001
1KY3	GDP-BOUND YPT7P AT 1.35 A RESOLUTION 分子名称: GTP-BINDING PROTEIN YPT7P, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Constantinescu, A.-T, Rak, A, Scheidig, A.J. 登録日 2002-02-02 公開日 2002-06-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases. Structure, 10, 2002
1JAI	H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MANGANESE 分子名称: C-HA-RAS, MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Schweins, T, Scheffzek, K, Assheuer, R, Wittinghofer, A. 登録日 1996-12-15 公開日 1997-07-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. J.Mol.Biol., 266, 1997

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