1LUK
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![BU of 1luk by Molmil](/molmil-images/mine/1luk) | NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure | 分子名称: | Tyrosine-protein kinase ITK/TSK | 著者 | Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. | 登録日 | 2002-05-22 | 公開日 | 2002-11-27 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
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1LUN
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![BU of 1lun by Molmil](/molmil-images/mine/1lun) | NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure | 分子名称: | Tyrosine-protein kinase ITK/TSK | 著者 | Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. | 登録日 | 2002-05-22 | 公開日 | 2002-11-27 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
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1M61
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![BU of 1m61 by Molmil](/molmil-images/mine/1m61) | |
1LUM
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![BU of 1lum by Molmil](/molmil-images/mine/1lum) | NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures | 分子名称: | Tyrosine-protein kinase ITK/TSK | 著者 | Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. | 登録日 | 2002-05-22 | 公開日 | 2002-11-27 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural characterization of a proline-driven conformational switch
within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
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1MW4
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![BU of 1mw4 by Molmil](/molmil-images/mine/1mw4) | |
1LCJ
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![BU of 1lcj by Molmil](/molmil-images/mine/1lcj) | |
1O4P
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![BU of 1o4p by Molmil](/molmil-images/mine/1o4p) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791. | 分子名称: | 2-PHENYLMALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4Q
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![BU of 1o4q by Molmil](/molmil-images/mine/1o4q) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256. | 分子名称: | PHENYL(SULFO)ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4N
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![BU of 1o4n by Molmil](/molmil-images/mine/1o4n) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID. | 分子名称: | OXALIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1NRV
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![BU of 1nrv by Molmil](/molmil-images/mine/1nrv) | |
1NZV
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![BU of 1nzv by Molmil](/molmil-images/mine/1nzv) | |
1O4D
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![BU of 1o4d by Molmil](/molmil-images/mine/1o4d) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262. | 分子名称: | 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4J
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![BU of 1o4j by Molmil](/molmil-images/mine/1o4j) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24. | 分子名称: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O43
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![BU of 1o43 by Molmil](/molmil-images/mine/1o43) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129. | 分子名称: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACET IC ACID | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O49
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![BU of 1o49 by Molmil](/molmil-images/mine/1o49) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493. | 分子名称: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4G
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![BU of 1o4g by Molmil](/molmil-images/mine/1o4g) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59. | 分子名称: | HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4M
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![BU of 1o4m by Molmil](/molmil-images/mine/1o4m) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID. | 分子名称: | MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O45
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![BU of 1o45 by Molmil](/molmil-images/mine/1o45) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687. | 分子名称: | N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4F
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![BU of 1o4f by Molmil](/molmil-images/mine/1o4f) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073. | 分子名称: | 1,2,3,4-TETRAHYDROQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4K
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![BU of 1o4k by Molmil](/molmil-images/mine/1o4k) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN. | 分子名称: | BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4A
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![BU of 1o4a by Molmil](/molmil-images/mine/1o4a) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197. | 分子名称: | 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1MIL
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![BU of 1mil by Molmil](/molmil-images/mine/1mil) | TRANSFORMING PROTEIN | 分子名称: | SHC ADAPTOR PROTEIN | 著者 | Mikol, V. | 登録日 | 1995-09-20 | 公開日 | 1996-11-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of the SH2 domain from the adaptor protein SHC: a model for peptide binding based on X-ray and NMR data. J.Mol.Biol., 254, 1995
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1O44
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![BU of 1o44 by Molmil](/molmil-images/mine/1o44) | Crystal structure of sh2 in complex with ru85052 | 分子名称: | 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4C
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![BU of 1o4c by Molmil](/molmil-images/mine/1o4c) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE. | 分子名称: | PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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1O4I
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![BU of 1o4i by Molmil](/molmil-images/mine/1o4i) | CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219. | 分子名称: | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate | 著者 | Lange, G, Loenze, P, Liesum, A. | 登録日 | 2003-06-15 | 公開日 | 2004-02-17 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
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