PDB: 1551 件ウェブページステータス検索Chemie searchBIRD

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3PLV	Structure of Hub-1 protein in complex with Snu66 peptide (HINDII) 分子名称: 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Ubiquitin-like modifier HUB1 著者 Mishra, S.K, Ammon, T, Popowicz, G.M, Krajewski, M, Nagel, R.J, Ares, M, Holak, T.A, Jentsch, S. 登録日 2010-11-15 公開日 2011-06-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature, 474, 2011
3PLU	Structure of Hub-1 protein in complex with Snu66 peptide (HINDI) 分子名称: 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component, Ubiquitin-like modifier HUB1 著者 Mishra, S.K, Ammon, T, Popowicz, G.M, Krajewski, M, Nagel, R.J, Ares, M, Holak, T.A, Jentsch, S. 登録日 2010-11-15 公開日 2011-06-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Role of the ubiquitin-like protein Hub1 in splice-site usage and alternative splicing. Nature, 474, 2011
7OS2	Cryo-EM structure of Brr2 in complex with Jab1/MPN and C9ORF78 分子名称: Pre-mRNA-processing-splicing factor 8, Telomere length and silencing protein 1 homolog, U5 small nuclear ribonucleoprotein 200 kDa helicase 著者 Bergfort, A, Hilal, T, Weber, G, Wahl, M.C. 登録日 2021-06-07 公開日 2022-02-23 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Res., 50, 2022
4MSX	Crystal structure of an essential yeast splicing factor 分子名称: ACETATE ION, Pre-mRNA-splicing factor SAD1, ZINC ION 著者 Hadjivassiliou, H, Guthrie, C, Rosenberg, O.S. 登録日 2013-09-18 公開日 2014-04-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. Rna, 20, 2014
3SBG	Crystal structure of a Prp8 C-terminal fragment 分子名称: Pre-mRNA-splicing factor 8 著者 Weber, G, Santos, K, Holton, N, Wahl, M.C. 登録日 2011-06-04 公開日 2012-04-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.28 Å) 主引用文献 Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev., 25, 2011
8ENK	Crystal structure of UAP56 in complex with Tho1, the yeast homolog of human SARNP 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... 著者 Xie, Y, Ren, Y. 登録日 2022-09-30 公開日 2023-08-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. Cell Rep, 42, 2023
2ALE	Crystal structure of yeast RNA splicing factor Snu13p 分子名称: MAGNESIUM ION, NHP2/L7aE family protein YEL026W 著者 Dobbyn, H.C, McEwan, P.A, Bella, J, O'Keefe, R.T. 登録日 2005-08-05 公開日 2006-10-03 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants. Biochem.Biophys.Res.Commun., 360, 2007
2VY5	U11-48K CHHC Zn-finger protein domain 分子名称: U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN, ZINC ION 著者 Tidow, H, Andreeva, A, Rutherford, T.J, Fersht, A.R. 登録日 2008-07-18 公開日 2009-02-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns. Structure, 17, 2009
7PX3	Structure of U5 snRNP assembly and recycling factor TSSC4 in complex with BRR2 and Jab1 domain of PRPF8 分子名称: Pre-mRNA-processing-splicing factor 8, Protein TSSC4, U5 small nuclear ribonucleoprotein 200 kDa helicase 著者 Bergfort, A, Kuropka, B, Ilik, I.A, Freund, C, Aktas, T, Hilal, T, Weber, G, Wahl, M.C. 登録日 2021-10-07 公開日 2022-01-26 最終更新日 2022-08-10 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Res., 50, 2022
3SBS	Crystal structure of Aar2 protein 分子名称: A1 cistron-splicing factor AAR2 著者 Weber, G, Santos, K.F, Holton, N, Wahl, M.C. 登録日 2011-06-06 公開日 2012-04-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev., 25, 2011
1XWN	solution structure of cyclophilin like 1(PPIL1) and insights into its interaction with SKIP 分子名称: Peptidyl-prolyl cis-trans isomerase like 1 著者 Xu, C, Xu, Y, Tang, Y, Wu, J, Shi, Y, Huang, Q, Zhang, Q. 登録日 2004-11-01 公開日 2005-10-18 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of human peptidyl prolyl isomerase like protein 1 and insights into its interaction with SKIP J.Biol.Chem., 281, 2006
6ZM2	Crystal structure of the DEAH-box ATPase Prp2 in complex with ADP-BeF3 and ssRNA 分子名称: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Hamann, F, Ficner, R. 登録日 2020-07-01 公開日 2021-04-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of Prp2 bound to RNA and ADP-BeF 3 - reveals structural features important for RNA unwinding by DEAH-box ATPases. Acta Crystallogr D Struct Biol, 77, 2021
4M7D	Crystal structure of Lsm2-8 complex bound to the RNA fragment CGUUU 分子名称: U6 snRNA, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ... 著者 Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. 登録日 2013-08-12 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.595 Å) 主引用文献 Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
4M75	Crystal structure of Lsm1-7 complex 分子名称: CHLORIDE ION, U6 snRNA-associated Sm-like protein Lsm1, U6 snRNA-associated Sm-like protein Lsm2, ... 著者 Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. 登録日 2013-08-12 公開日 2013-10-23 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
4M77	Crystal structure of Lsm2-8 complex, space group I212121 分子名称: U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, U6 snRNA-associated Sm-like protein LSm4, ... 著者 Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. 登録日 2013-08-12 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.111 Å) 主引用文献 Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
4M78	Crystal structure of Lsm2-8 complex, space group P21 分子名称: U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, U6 snRNA-associated Sm-like protein LSm4, ... 著者 Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. 登録日 2013-08-12 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.794 Å) 主引用文献 Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
4M7A	Crystal structure of Lsm2-8 complex bound to the 3' end sequence of U6 snRNA 分子名称: U6 snRNA, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3, ... 著者 Zhou, L, Hang, J, Zhou, Y, Wan, R, Lu, G, Yan, C, Shi, Y. 登録日 2013-08-12 公開日 2013-11-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.781 Å) 主引用文献 Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature, 506, 2014
4PYU	The conserved ubiquitin-like protein hub1 plays a critical role in splicing in human cells 分子名称: U4/U6.U5 tri-snRNP-associated protein 1, Ubiquitin-like protein 5 著者 Ammon, T, Mishra, S.K, Kowalska, K, Popowicz, G.M, Holak, T.A, Jentsch, S. 登録日 2014-03-28 公開日 2014-07-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. J Mol Cell Biol, 6, 2014
6S8Q	Human Brr2 Helicase Region in complex with C-tail deleted Jab1 分子名称: Pre-mRNA-processing-splicing factor 8, SULFATE ION, U5 small nuclear ribonucleoprotein 200 kDa helicase 著者 Santos, K.F, Vester, K, Wahl, M.C. 登録日 2019-07-10 公開日 2020-01-22 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.391 Å) 主引用文献 The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
6S9I	Human Brr2 Helicase Region D534C/N1866C in complex with C-tail deleted Jab1 分子名称: Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase 著者 Vester, K, Santos, K.F, Wahl, M.C. 登録日 2019-07-13 公開日 2020-01-22 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (2.598 Å) 主引用文献 The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
2OG4	Structure of an expanded Jab1-MPN-like domain of splicing factor Prp8p from yeast 分子名称: Pre-mRNA-splicing factor 8 著者 Pena, V, Liu, S, Luehrmann, R, Wahl, M.C. 登録日 2007-01-05 公開日 2007-03-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa. Mol.Cell, 25, 2007
4PKD	U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2 分子名称: IMIDAZOLE, MAGNESIUM ION, U1 small nuclear ribonucleoprotein A,U1 small nuclear ribonucleoprotein 70 kDa, ... 著者 Oubridge, C, Kondo, Y, van Roon, A.M, Nagai, K. 登録日 2014-05-14 公開日 2014-12-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. Elife, 4, 2015
3EGN	C-terminal RNA Recognition Motif of the U11/U12 65K Protein 分子名称: RNA-binding protein 40 著者 Netter, C, Wahl, M.C. 登録日 2008-09-11 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion Rna, 15, 2009
7OS1	Cryo-EM structure of Brr2 in complex with Fbp21 分子名称: U5 small nuclear ribonucleoprotein 200 kDa helicase, WW domain-binding protein 4 著者 Bergfort, A, Hilal, T, Weber, G, Wahl, M.C. 登録日 2021-06-07 公開日 2022-02-23 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Res., 50, 2022
8ID2	Crystal structure of the ubiquitin-like domain in the SF3A1 subunit of human U2 snRNP complexed with the stem-loop 4 of U1 snRNA 分子名称: RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*CP*GP*UP*UP*CP*GP*CP*GP*CP*UP*UP*UP*CP*CP*CP*C)-3'), Splicing factor 3A subunit 1 著者 Terawaki, S, Nameki, N, Kuwasako, K. 登録日 2023-02-12 公開日 2023-05-17 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into recognition of SL4, the UUCG stem-loop, of human U1 snRNA by the ubiquitin-like domain, including the C-terminal tail in the SF3A1 subunit of U2 snRNP. J.Biochem., 174, 2023

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