PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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4RUO	Crystal structure of zVDR L337H mutant-gemini complex 分子名称: 21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL, 20-(4-HYDROXY-4-METHYLPENTYL)-, (1A,3B,5Z,7E), ... 著者 Huet, T, Moras, D, Rochel, N. 登録日 2014-11-21 公開日 2015-10-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.805 Å) 主引用文献 A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep, 10, 2015
5HG8	EGFR (L858R, T790M, V948R) in complex with N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]prop-2-enamide 分子名称: Epidermal growth factor receptor, GLYCEROL, N-[3-({2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]propanamide, ... 著者 Gajiwala, K.S. 登録日 2016-01-08 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J.Med.Chem., 59, 2016
1SWI	GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A COMPLEXED WITH BENZENE 分子名称: BENZENE, GCN4P1 著者 Gonzalez, L, Plecs, J, Alber, T. 登録日 1996-05-09 公開日 1996-11-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 An engineered allosteric switch in leucine-zipper oligomerization. Nat.Struct.Biol., 3, 1996
4S31	Crystal structure of mitogen-activated protein kinase 1 wtERK2 at 1.45A 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
4RUP	Crystal structure of zVDR L337H mutant-Gemini72 complex 分子名称: (1R,3R,7E,17beta)-17-[(1R)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,1 0-secoestra-5,7-diene-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A 著者 Huet, T, Moras, D, Rochel, N. 登録日 2014-11-21 公開日 2015-10-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects. Cell Rep, 10, 2015
6E1Y	Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design 分子名称: N-[(1S)-1-(3-chlorophenyl)ethyl]-3-{[(4,5-dihydro-1H-imidazol-2-yl)amino]methyl}benzamide, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-07-10 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.219 Å) 主引用文献 Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
2K2U	NMR Structure of the complex between Tfb1 subunit of TFIIH and the activation domain of VP16 分子名称: Alpha trans-inducing protein, RNA polymerase II transcription factor B subunit 1 著者 Langlois, C, Mas, C, Di Lello, P, Miller Jenkins, P.M, Legault, J, Omichinski, J.G. 登録日 2008-04-11 公開日 2008-08-12 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR Structure of the Complex between the Tfb1 Subunit of TFIIH and the Activation Domain of VP16: Structural Similarities between VP16 and p53. J.Am.Chem.Soc., 130, 2008
6E1Z	Displacement of WDR5 from chromatin by a pharmacological WIN site inhibitor with picomolar affinity 分子名称: 5-[(1H-imidazol-1-yl)methyl]furan-2-carboxylic acid, WD repeat-containing protein 5 著者 Phan, J, Fesik, S.W. 登録日 2018-07-10 公開日 2019-03-13 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep, 26, 2019
4EJU	Staphylococcus epidermidis TcaR full length 分子名称: Transcriptional regulator TcaR 著者 Chang, Y.M, Chen, C.K.M, Wang, A.H.J. 登録日 2012-04-07 公開日 2013-05-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural analysis of the antibiotic recognition mechanism of MarR family proteins Acta Crystallogr.,Sect.D, 2013
5HCQ	Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Gagnon, M.G, Roy, R.N, Lomakin, I.B, Florin, T, Mankin, A.S, Steitz, T.A. 登録日 2016-01-04 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res., 44, 2016
4Q0A	Vitamin D Receptor complex with lithocholic acid 分子名称: (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, Nuclear receptor coactivator 2, Vitamin D3 receptor A 著者 Belorusova, A, Rochel, N. 登録日 2014-04-01 公開日 2014-07-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into the molecular mechanism of vitamin d receptor activation by lithocholic Acid involving a new mode of ligand recognition. J.Med.Chem., 57, 2014
5HG7	EGFR (L858R, T790M, V948R) in complex with 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988) 分子名称: 1-{(3R,4R)-3-[({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}propan-1-one, Epidermal growth factor receptor, SULFATE ION 著者 Gajiwala, K.S. 登録日 2016-01-08 公開日 2016-01-27 最終更新日 2016-03-23 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J.Med.Chem., 59, 2016
5HAU	Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... 著者 Gagnon, M.G, Roy, R.N, Lomakin, I.B, Florin, T, Mankin, A.S, Steitz, T.A. 登録日 2015-12-30 公開日 2016-04-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res., 44, 2016
7K56	Structure of VCP dodecamer purified from H1299 cells 分子名称: Transitional endoplasmic reticulum ATPase 著者 Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y. 登録日 2020-09-16 公開日 2021-10-13 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation. Iscience, 24, 2021
7K59	Structure of apo VCP hexamer generated from bacterially recombinant VCP/p97 分子名称: Transitional endoplasmic reticulum ATPase 著者 Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y. 登録日 2020-09-16 公開日 2021-10-13 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation. Iscience, 24, 2021
7K57	Structure of apo VCP dodecamer generated from bacterially recombinant VCP/p97 分子名称: Transitional endoplasmic reticulum ATPase 著者 Yu, G, Bai, Y, Li, K, Jiang, W, Zhang, Z.Y. 登録日 2020-09-16 公開日 2021-10-13 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation. Iscience, 24, 2021
1UNU	Structure Based Engineering of Internal Molecular Surfaces Of Four Helix Bundles 分子名称: CHLORIDE ION, GENERAL CONTROL PROTEIN GCN4 著者 Yadav, M.K, Redman, J.E, Alvarez-Gutierrez, J.M, Zhang, Y, Stout, C.D, Ghadiri, M.R. 登録日 2003-09-15 公開日 2004-10-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structure-Based Engineering of Internal Cavities in Coiled-Coil Peptides Biochemistry, 44, 2005
7KRD	Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 4-(3-chloro-5-cyanophenoxy)-3-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenyl sulfurofluoridate (JLJ702) 分子名称: 4-(3-chloro-5-cyanophenoxy)-3-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenyl sulfurofluoridate, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, ... 著者 Bertoletti, N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. 登録日 2020-11-19 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead. Acs Med.Chem.Lett., 12, 2021
2F20	X-ray Crystal Structure of Protein BT_1218 from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium Target BtR8. 分子名称: conserved hypothetical protein, with conserved domain 著者 Vorobiev, S.M, Abashidze, M, Seetharaman, J, Forouhar, F, Xiao, R, Ma, L.-C, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2005-11-15 公開日 2005-11-22 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the Q8A8E9_BACTIN hypothetical protein from Bacteroides thetaiotaomicron. To be Published
4E2Q	Crystal Structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana 分子名称: MANGANESE (II) ION, Ureidoglycine aminohydrolase 著者 Shin, I, Rhee, S. 登録日 2012-03-09 公開日 2012-04-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana J.Biol.Chem., 287, 2012
4E2S	Crystal structure of (S)-Ureidoglycine Aminohydrolase from Arabidopsis thaliana in complex with its substrate, (S)-Ureidoglycine 分子名称: (2S)-amino(carbamoylamino)ethanoic acid, MANGANESE (II) ION, Ureidoglycine aminohydrolase 著者 Shin, I, Rhee, S. 登録日 2012-03-09 公開日 2012-04-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana J.Biol.Chem., 287, 2012
4QL1	Crystal structure of human WDR5 in complex with compound OICR-9429 分子名称: 1,2-ETHANEDIOL, GLYCEROL, N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ... 著者 Dong, A, Dombrovski, L, Walker, J.R, Getlik, M, Kuznetsova, E, Smil, D, Barsyte, D, Li, F, Poda, G, Senisterra, G, Marcellus, R, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2014-06-10 公開日 2014-12-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Pharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia. Nat.Chem.Biol., 11, 2015
1V4R	Solution structure of Streptmycal repressor TraR 分子名称: Transcriptional Repressor 著者 Tanaka, T, Komatsu, C, Kobayashi, K, Sugai, M, Kataoka, M, Kohno, T. 登録日 2003-11-17 公開日 2005-03-01 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of Streptmycal repressor TraR TO BE PUBLISHED
4S33	ERK2 R65S mutant complexed with AMP-PNP 分子名称: MAGNESIUM ION, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Livnah, O, Karamansha, Y, Tzarum, N. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
5XBI	The structure of BrlR-C domain bound to 3-amino-2-phenazino(a pyocyanin analog) 分子名称: 3-azanylphenazin-2-ol, DI(HYDROXYETHYL)ETHER, Probable transcriptional regulator 著者 Wang, F, Qing, H, Gu, L. 登録日 2017-03-17 公開日 2018-03-21 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin. Nat Commun, 9, 2018

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