PDB: 31489 件ウェブページステータス検索Chemie searchBIRD

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7Q7Z	Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine) 分子名称: GUANINE, MAGNESIUM ION, RNA 1, ... 著者 Mieczkowski, M, Hoebartner, C. 登録日 2021-11-09 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.26 Å) 主引用文献 Structure and mechanism of the methyltransferase ribozyme MTR1. Nat.Chem.Biol., 18, 2022
7Q81	Crystal structure of the methyltransferase-ribozyme 1, 2'-Selenomethyl-Uridine modified (with 1-methyl-adenosine) 分子名称: GUANINE, MAGNESIUM ION, RNA 2, ... 著者 Mieczkowski, M, Hoebartner, C. 登録日 2021-11-09 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure and mechanism of the methyltransferase ribozyme MTR1. Nat.Chem.Biol., 18, 2022
7BIL	Crystal structure of helicase Pif1 from Thermus oshimai in complex with oligo GGTTTGGTTTGGTT 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*GP*GP*TP*TP*TP*GP*GP*TP*TP*TP*GP*GP*TP*T)-3'), MAGNESIUM ION, ... 著者 Dai, Y.X, Chen, W.F, Teng, F.Y, Liu, N.N, Hou, X.M, Dou, S.X, Rety, S, Xi, X.G. 登録日 2021-01-12 公開日 2021-04-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition. Nucleic Acids Res., 49, 2021
7Q7X	Crystal structure of the methyltransferase-ribozyme 1 (with 1-methyl-adenosine) 分子名称: GUANINE, MAGNESIUM ION, RNA 1, ... 著者 Mieczkowski, M, Hoebartner, C. 登録日 2021-11-09 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure and mechanism of the methyltransferase ribozyme MTR1. Nat.Chem.Biol., 18, 2022
7BIT	Inhibitor of MDM2-p53 Interaction 分子名称: (3~{R})-2-[(5-chloranylpyridin-2-yl)methyl]-3-(4-chlorophenyl)-4-fluoranyl-3-[(1-oxidanylcyclopropyl)methoxy]-6-(2-oxidanylpropan-2-yl)isoindol-1-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Williams, P.A. 登録日 2021-01-13 公開日 2021-04-07 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
6K77	Crystal structure of AMPPNP bound Ck1a alpha from C. neoformans 分子名称: Casein kinase II subunit alpha, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Cho, H.S, Yoo, Y. 登録日 2019-06-06 公開日 2020-06-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of AMPPNP bound Cka1 alpha from C. neoformans To Be Published
6BXT	Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 A (MAF1A) in complex with ADPribose 分子名称: ADENOSINE-5-DIPHOSPHORIBOSE, mitochondrial association factor 1 著者 Parker, M.L, Ramaswamy, R, Boulanger, M.J. 登録日 2017-12-18 公開日 2018-12-19 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions. Mol. Microbiol., 108, 2018
8TS0	Crystal Structure of human ASGR1 CRD (Carbohydrate Recognition Domain) bound to 8M24 Fab 分子名称: 8M24 Fab Heavy chain, 8M24 Fab Light chain, Asialoglycoprotein receptor 1, ... 著者 Sampathkumar, P, Li, Y. 登録日 2023-08-10 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Targeted protein degradation systems to enhance Wnt signaling. Elife, 13, 2024
6JT4	Crystal Structure of BACE1 in complex with N-{3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide 分子名称: Beta-secretase 1, GLYCEROL, IODIDE ION, ... 著者 Anan, K, Iso, Y, Oguma, T, Nakahara, K, Suzuki, S, Yamamoto, T, Matsuoka, E, Ito, H, Sakaguchi, G, Ando, S, Morimoto, K, Kanegawa, N, Kido, Y, Kawachi, T, Fukushima, T, Teisman, A, Urmaliya, V, Dhuyvetter, D, Borghys, H, Austin, N, Bergh, A.V.D, Verboven, P, Bischoff, F, Gijsen, H.J.M, Yamano, Y, Kusakabe, K.I. 登録日 2019-04-08 公開日 2020-01-15 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Trifluoromethyl Dihydrothiazine-Based beta-Secretase (BACE1) Inhibitors with Robust Central beta-Amyloid Reduction and Minimal Covalent Binding Burden. Chemmedchem, 14, 2019
7Q80	Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine) 分子名称: GUANINE, RNA 1, RNA 2, ... 著者 Mieczkowski, M, Hoebartner, C. 登録日 2021-11-09 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Structure and mechanism of the methyltransferase ribozyme MTR1. Nat.Chem.Biol., 18, 2022
7ZTX	Crystal structure of mutant AR-LBD (F755V) bound to dihydrotestosterone 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, IMIDAZOLE, ... 著者 Alegre-Marti, A, Jimenez-Panizo, A, Estebanez-Perpina, E, Fuentes-Prior, P. 登録日 2022-05-11 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance. Sci Adv, 9, 2023
7MY0	Sy-CrtE IPP structure 分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, GLYCEROL, Geranylgeranyl pyrophosphate synthase, ... 著者 Peat, T.S, Newman, J. 登録日 2021-05-19 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Molecular characterization of cyanobacterial short-chain prenyltransferases and discovery of a novel GGPP phosphatase. Febs J., 289, 2022
7BTZ	Crystal structure of TrmO 分子名称: Putative tRNA (Adenine(37)-N6)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Fan, C.P, Wang, L, Hu, W.H, Yang, C.W. 登録日 2020-04-03 公開日 2021-04-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of TrmO from Pseudomonas aeruginosa To Be Published
8T7P	X-ray crystal structure of PfA-M1(M462S) 分子名称: Aminopeptidase N, GLYCEROL, MAGNESIUM ION, ... 著者 Yang, W, Drinkwater, N, Webb, C.T, McGowan, S. 登録日 2023-06-21 公開日 2024-06-26 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Conformational dynamics of the Plasmodium falciparum M1 aminopeptidase. To Be Published
7ZT0	Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor 分子名称: 1-(2-piperazin-1-ylethyl)-5-pyridin-4-yl-indole-2-carboxamide, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Snee, M, Katariya, M, Levy, C, Leys, D. 登録日 2022-05-09 公開日 2023-04-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis. Chemistry, 29, 2023
8TDH	Structure of trehalose bound Alistipes sp. Glucoside-3-dehydrogenase AL3 分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Predicted dehydrogenases and related proteins, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose 著者 Lazarski, A.C, Worrall, L.J, Strynadka, N.C.J. 登録日 2023-07-03 公開日 2024-06-19 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature, 631, 2024
6C0M	The synthesis, biological evaluation and structural insights of unsaturated 3-N-substituted sialic acids as probes of human parainfluenza virus-3 haemagglutinin-neuraminidase 分子名称: 1,2-ETHANEDIOL, 2,6-anhydro-3,5-dideoxy-5-[(2-methylpropanoyl)amino]-3-(4-phenyl-1H-1,2,3-triazol-1-yl)-D-glycero-D-galacto-non-2-enoni c acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dirr, L, Ve, T, von Itzstein, M. 登録日 2018-01-01 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin-Neuraminidase Using Unsaturated 3- N-Substituted Sialic Acids as Probes. ACS Chem. Biol., 13, 2018
7Q82	Crystal structure of the methyltransferase-ribozyme 1, Thallium derivative (with 1-methyl-adenosine) 分子名称: GUANINE, MAGNESIUM ION, RNA 1, ... 著者 Mieczkowski, M, Hoebartner, C. 登録日 2021-11-09 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure and mechanism of the methyltransferase ribozyme MTR1. Nat.Chem.Biol., 18, 2022
7BUI	Complex of reduced oxygenase and oxidized ferredoxin in carbazole 1,9a- dioxygenase 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, FE (II) ION, ... 著者 Matsuzawa, J, Wang, Y.X, Suzuki-Minakuchi, C, Nojiri, H. 登録日 2020-04-06 公開日 2021-04-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Complex of reduced oxygenase and oxidized ferredoxin in carbazole 1,9a- dioxygenase To Be Published
7ZTV	Crystal structure of mutant AR-LBD (F755L) bound to dihydrotestosterone 分子名称: 1,2-ETHANEDIOL, 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor 著者 Alegre-Marti, A, Jimenez-Panizo, A, Estebanez-Perpina, E, Fuentes-Prior, P. 登録日 2022-05-11 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance. Sci Adv, 9, 2023
6C7G	Crystal structure of human phosphodiesterase 2A with N-(1-adamantyl)-1-(2-chloro-5-isobutoxy-phenyl)-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide 分子名称: 1-[2-chloro-5-(2-methylpropoxy)phenyl]-4-methyl-N-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl][1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide, MAGNESIUM ION, ZINC ION, ... 著者 Xu, R, Aertgeerts, K. 登録日 2018-01-22 公開日 2018-08-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes. J. Med. Chem., 61, 2018
8A2V	Room temperature structure of the ground state of AtPhot2LOV2 in space group P43212 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FLAVIN MONONUCLEOTIDE, Phototropin-2 著者 Engilberge, S, Caramello, N, Royant, A. 登録日 2022-06-06 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Slow protein dynamics probed by time-resolved oscillation crystallography at room temperature. Iucrj, 9, 2022
8TDA	Structure of Bacteroides thetaiotaomicron 3-Keto-2-hydroxy-glucal-hydratase BT2 分子名称: POTASSIUM ION, Probable secreted glycosyl hydrolase 著者 Lazarski, A.C, Worrall, L.J, Strynadka, N.C.J. 登録日 2023-07-02 公開日 2024-06-12 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 An alternative broad-specificity pathway for glycan breakdown in bacteria. Nature, 631, 2024
7Q7Y	Crystal structure of the methyltransferase-ribozyme 1 (1-benzyl-adenosine derivative) 分子名称: GUANINE, MAGNESIUM ION, RNA 1, ... 著者 Mieczkowski, M, Hoebartner, C. 登録日 2021-11-09 公開日 2022-03-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure and mechanism of the methyltransferase ribozyme MTR1. Nat.Chem.Biol., 18, 2022
6C7X	Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine 分子名称: 2-chloro-5'-O-sulfamoyladenosine, Carbonic anhydrase 2, SODIUM ION, ... 著者 Peat, T.S, Mujumdar, P, Poulsen, S.A. 登録日 2018-01-23 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Synthesis, structure and bioactivity of primary sulfamate-containing natural products. Bioorg. Med. Chem. Lett., 28, 2018

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