PDB: 274 件ウェブページステータス検索Chemie searchBIRD

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7MS6	Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with (2-fluoro-4-((4-phenylpiperidin-1-yl)sulfonyl)benzoyl)glycine 分子名称: 1,2-ETHANEDIOL, N-[2-fluoro-4-(4-phenylpiperidine-1-sulfonyl)benzoyl]glycine, SULFATE ION, ... 著者 Mann, M.K, Zepeda-Velazquez, C.A, Alvarez, H.G, Dong, A, Kiyota, T, Aman, A, Arrowsmith, C.H, Al-Awar, R, Harding, R.J, Schapira, M. 登録日 2021-05-10 公開日 2021-06-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure-Activity Relationship of USP5 Inhibitors. J.Med.Chem., 64, 2021
3PV1	Crystal structure of the USP15 DUSP-UBL domains 分子名称: ACETATE ION, Ubiquitin carboxyl-terminal hydrolase 15 著者 Elliott, P.R, Urbe, S, Clague, M.J, Barsukov, I.L. 登録日 2010-12-06 公開日 2011-11-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural variability of the ubiquitin specific protease DUSP-UBL double domains. Febs Lett., 585, 2011
8G6P	Crystal structure of Mycobacterium thermoresistibile MurE in complex with ADP and 2,6-Diaminopimelic acid 分子名称: 2,6-DIAMINOPIMELIC ACID, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... 著者 Rossini, N.O, Silva, C.S, Dias, M.V.B. 登録日 2023-02-15 公開日 2023-04-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The crystal structure of Mycobacterium thermoresistibile MurE ligase reveals the binding mode of the substrate m-diaminopimelate. J.Struct.Biol., 215, 2023
8GF3	Crystallographic structure from BlMan5_7 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... 著者 Briganti, L, Araujo, E.A, Polikarpov, I. 登録日 2023-03-07 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Crystallographic structure from BlMan5_7 To be published
7MS7	Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with (5-((4-(4-chlorophenyl)piperidin-1-yl)sulfonyl)picolinoyl)glycine 分子名称: 1,2-ETHANEDIOL, ACETATE ION, N-{5-[4-(4-chlorophenyl)piperidine-1-sulfonyl]pyridine-2-carbonyl}glycine, ... 著者 Mann, M.K, Zepeda-Velazquez, C.A, Alvarez, H.G, Dong, A, Kiyota, T, Aman, A, Arrowsmith, C.H, Al-Awar, R, Harding, R.J, Schapira, M. 登録日 2021-05-10 公開日 2021-06-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure-Activity Relationship of USP5 Inhibitors. J.Med.Chem., 64, 2021
7MS5	Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 4-(4-(4-(3,4-difluoro-phenyl)-piperidin-1-ylsulfonyl)-phenyl)-4-oxo-butanoic acid 分子名称: 1,2-ETHANEDIOL, 4-{4-[4-(3,4-difluorophenyl)piperidine-1-sulfonyl]phenyl}-4-oxobutanoic acid, CALCIUM ION, ... 著者 Mann, M.K, Zepeda-Velazquez, C.A, Alvarez, H.G, Dong, A, Kiyota, T, Aman, A, Arrowsmith, C.H, Al-Awar, R, Harding, R.J, Schapira, M, Structural Genomics Consortium (SGC) 登録日 2021-05-10 公開日 2021-06-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure-Activity Relationship of USP5 Inhibitors. J.Med.Chem., 64, 2021
2MUX	SUMO2 non-covalently interacts with USP25 and downregulates its activity 分子名称: Ubiquitin carboxyl-terminal hydrolase 25 著者 Shi, L, Zhang, N, Wen, Y. 登録日 2014-09-18 公開日 2016-04-20 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 SUMO2 non-covalently interacts with USP25 and downregulates its activity To be Published
2DAG	Solution Structure of the First UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5) 分子名称: Ubiquitin carboxyl-terminal hydrolase 5 著者 Zhao, C, Kigawa, T, Tomizawa, T, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-14 公開日 2006-06-14 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the First UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5) To be Published
2DAK	Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5) 分子名称: Ubiquitin carboxyl-terminal hydrolase 5 著者 Zhao, C, Kigawa, T, Sato, M, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-14 公開日 2006-06-14 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5) To be Published
6BCM	Structure of a Self-inhibited N475A variant of the Venezuelan Equine Encephalitis Virus (VEEV) nsP2 cysteine protease 分子名称: GLYCEROL, Protease nsP2, SODIUM ION 著者 Compton, J.R, Legler, P.M. 登録日 2017-10-20 公開日 2017-11-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State. Biochemistry, 56, 2017
3IXP	Crystal structure of the ecdysone receptor bound to BYI08346 分子名称: Ecdysone receptor, Gene regulation protein, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ... 著者 Moras, D, Billas, I.M.L, Browning, C. 登録日 2009-09-04 公開日 2010-12-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Adaptability of the ecdysone receptor bound to synthetic ligands To be Published
7SFP	Crystal structure of OssO, a spirocyclase involved in the biosynthesis of ossamycin 分子名称: Spirocyclase 著者 Bilyk, O, Leadlay, P.F, Dias, M.V.B. 登録日 2021-10-04 公開日 2022-08-17 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis. J.Am.Chem.Soc., 144, 2022
7SFN	Crystal structure of OlmO, a spirocyclase involved in the biosynthesis of oligomycin 分子名称: D-MALATE, OlmO - oligomycin spirocyclase 著者 Bilyk, O, Leadlay, P.F, Dias, M.V.B. 登録日 2021-10-04 公開日 2022-08-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis. J.Am.Chem.Soc., 144, 2022
2I50	Solution Structure of Ubp-M Znf-UBP domain 分子名称: Ubiquitin carboxyl-terminal hydrolase 16, ZINC ION 著者 Pai, M.-T. 登録日 2006-08-23 公開日 2007-08-07 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. J.Mol.Biol., 370, 2007
2JAX	Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis 分子名称: ADENOSINE-5'-TRIPHOSPHATE, HYPOTHETICAL PROTEIN TB31.7, UNKNOWN ATOM OR ION 著者 Oberschall, A, Bourenkov, G, Strizhov, N, Bartunik, H.D. 登録日 2006-11-30 公開日 2007-12-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 Crystal Structure of Universal Stress Protein Rv2623 from Mycobacterium Tuberculosis To be Published
7ZJV	Structure of human USPL1 in covalent complex with DeltaN-SUMO2/3-PA probe 分子名称: CHLORIDE ION, SUMO-specific isopeptidase USPL1, Small ubiquitin-related modifier 2, ... 著者 Zhao, Z, Gersch, M. 登録日 2022-04-12 公開日 2023-09-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases. J.Am.Chem.Soc., 145, 2023
7ZJU	Structure of human USPL1 in covalent complex with SUMO3-2Br probe 分子名称: 2-bromanylethanamine, CALCIUM ION, CHLORIDE ION, ... 著者 Zhao, Z, Gersch, M. 登録日 2022-04-12 公開日 2023-09-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases. J.Am.Chem.Soc., 145, 2023
3ZLZ	Lys6-linked tri-ubiquitin 分子名称: UBIQUITIN, ZINC ION 著者 Hospenthal, M.K, Freund, S.M.V, Komander, D. 登録日 2013-02-04 公開日 2013-04-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Assembly, Analysis and Architecture of Atypical Ubiquitin Chains Nat.Struct.Mol.Biol., 20, 2013
4A3O	Crystal structure of the USP15 DUSP-UBL monomer 分子名称: GLYCEROL, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 著者 Elliott, P.R, Liu, H, Pastok, M.W, Grossmann, G.J, Rigden, D.J, Clague, M.J, Urbe, S, Barsukov, I.L. 登録日 2011-10-03 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Variability of the Ubiquitin Specific Protease Dusp-Ubl Double Domains. FEBS Lett., 585, 2011
4A3P	Structure of USP15 DUSP-UBL deletion mutant 分子名称: ACETATE ION, IODIDE ION, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 著者 Elliott, P.R, Liu, H, Pastok, M.W, Grossmann, G.J, Rigden, D.J, Clague, M.J, Urbe, S, Barsukov, I.L. 登録日 2011-10-03 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structural Variability of the Ubiquitin Specific Protease Dusp-Ubl Double Domains. FEBS Lett., 585, 2011
5OK6	Ubiquitin specific protease 11 USP11 - peptide F complex 分子名称: 1,2-ETHANEDIOL, ALA-GLU-GLY-GLU-PHE-TYR-LYS-LEU-LYS-ILE-ARG-THR-PRO-AAR, GLYCEROL, ... 著者 Spiliotopoulos, A, Dreveny, I. 登録日 2017-07-25 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11. J.Biol.Chem., 294, 2019
8DH6	Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid nanodiscs 分子名称: CALCIUM ION, COPPER (II) ION, Cytochrome c oxidase subunit 1, ... 著者 Godoy, A.S, Song, Y, Cheruvara, H, Quigley, A, Oliva, G. 登録日 2022-06-25 公開日 2022-07-20 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid nanodiscs To Be Published
8DH7	Cryo-EM structure of Saccharomyces cerevisiae Succinyl-CoA:acetate CoA-transferase (Ach1p) 分子名称: Acetyl-CoA hydrolase 著者 Godoy, A.S, Song, Y, Cheruvara, H, Quigley, A, Oliva, G. 登録日 2022-06-25 公開日 2022-07-20 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid nanodiscs To Be Published
8DKT	Crystal Structure of Septin1 - Septin2 heterocomplex from Drosophila melanogaster 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 de Freitas, A.F, Leonardo, D.A, Cavini, I.A, Pereira, H.M, Garratt, R.C. 登録日 2022-07-06 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Conservation and divergence of the G-interfaces of Drosophila melanogaster septins. Cytoskeleton (Hoboken), 80, 2023
8E25	Crystal Structure of SARS-CoV-2 Main Protease M49I mutant in complex with Nirmatrelvir 分子名称: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, DIMETHYL SULFOXIDE, Replicase polyprotein 1ab 著者 Noske, G.D, Godoy, A.S, Oliva, G. 登録日 2022-08-14 公開日 2022-10-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.868 Å) 主引用文献 Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease. J.Biol.Chem., 299, 2023

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