PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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7ZWD	Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. 登録日 2022-05-19 公開日 2022-11-30 最終更新日 2022-12-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
7XTI	RNA polymerase II elongation complex transcribing a nucleosome (EC58hex) 分子名称: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ... 著者 Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2022-05-17 公開日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Science, 377, 2022
7XT7	RNA polymerase II elongation complex transcribing a nucleosome (EC49B) 分子名称: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ... 著者 Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2022-05-16 公開日 2022-10-12 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Science, 377, 2022
7XTD	RNA polymerase II elongation complex transcribing a nucleosome (EC58oct) 分子名称: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ... 著者 Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2022-05-16 公開日 2022-09-07 最終更新日 2022-10-19 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Science, 377, 2022
7XSZ	RNA polymerase II elongation complex transcribing a nucleosome (EC115) 分子名称: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ... 著者 Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2022-05-15 公開日 2022-09-07 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Science, 377, 2022
7XSX	RNA polymerase II elongation complex transcribing a nucleosome (EC49) 分子名称: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ... 著者 Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2022-05-15 公開日 2022-09-07 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Science, 377, 2022
8CTF	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid 分子名称: 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ACETATE ION, MANGANESE (II) ION, ... 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-05-14 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
7XSE	RNA polymerase II elongation complex transcribing a nucleosome (EC42) 分子名称: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ... 著者 Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2022-05-13 公開日 2022-09-07 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Science, 377, 2022
7V04	The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide 分子名称: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide, MANGANESE (II) ION, Polymerase acidic protein 著者 Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. 登録日 2022-05-09 公開日 2022-12-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
7ZSB	Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP, complex C 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Wang, H, Cramer, P. 登録日 2022-05-06 公開日 2022-11-16 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (6.6 Å) 主引用文献 Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023
7ZSA	Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome and NTP (complex B) 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Wang, H, Cramer, P. 登録日 2022-05-06 公開日 2022-11-16 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023
7ZS9	Yeast RNA polymerase II transcription pre-initiation complex with the +1 nucleosome (complex A) 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Wang, H, Cramer, P. 登録日 2022-05-06 公開日 2022-11-16 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nat.Struct.Mol.Biol., 30, 2023
7ZPY	Influenza polymerase A C-terminal domain of PA subunit with optimized small peptide inhibitor 分子名称: METHOXY-ETHOXYL, Peptide inhibitor (ASP-TYR-ASN-PRO-TYR-LEU-LEU-TYR-LEU-LYS), Polymerase acidic protein 著者 Radilova, K, Brynda, J. 登録日 2022-04-29 公開日 2022-10-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction. Antiviral Res., 208, 2022
7UUH	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-2 (cis-form) 分子名称: (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-04-28 公開日 2022-11-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
7XN7	RNA polymerase II elongation complex containing Spt4/5, Elf1, Spt6, Spn1 and Paf1C 分子名称: Chromatin elongation factor SPT5, Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, ... 著者 Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S. 登録日 2022-04-28 公開日 2022-09-07 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT. Science, 377, 2022
7ZPM	Influenza A/H7N9 polymerase apo-protein dimer complex 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit 著者 Cusack, S, Kouba, T. 登録日 2022-04-27 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7ZPL	Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook 分子名称: 5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ... 著者 Cusack, S, Kouba, T. 登録日 2022-04-27 公開日 2022-12-28 最終更新日 2023-02-15 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023
7XME	Structure of Influenza A virus polymerase basic protein 2 (PB2) with an azazindole derivative 分子名称: (2~{S},3~{S})-3-[[5-dimethoxyphosphoryl-4-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, IODIDE ION, Polymerase basic protein 2 著者 Zhang, Z. 登録日 2022-04-25 公開日 2023-05-03 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.521 Å) 主引用文献 Discovery of a novel azaindole derivatives targeting the influenza PB2 cap binding region To Be Published
7UO7	SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Non-structural protein 7, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO9	SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOB	SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UOE	SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state 分子名称: 3'-DEOXYURIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7UO4	SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state 分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... 著者 Malone, B.F, Perry, J.K, Appleby, T.C, Feng, J.Y, Campbell, E.A, Darst, S.A. 登録日 2022-04-12 公開日 2022-11-30 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structural basis for substrate selection by the SARS-CoV-2 replicase. Nature, 614, 2023
7ZIU	Crystal structure of Ntaya virus NS5 polymerase domain 分子名称: Genome polyprotein, ZINC ION 著者 Krejcova, K, Klima, M, Boura, E. 登録日 2022-04-08 公開日 2023-04-19 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase. Structure, 2024
7UMR	The crystal structure of wild type PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001034732-1 (trans-form) 分子名称: (1P,18Z)-5-hydroxy-16,21-dioxa-3,8,28-triazatetracyclo[20.3.1.1~2,6~.1~11,15~]octacosa-1(26),2(28),5,11(27),12,14,18,22,24-nonaene-4,7-dione, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... 著者 Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. 登録日 2022-04-07 公開日 2022-10-12 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023

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