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PDB: 82 件
5KX7
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BU of 5kx7 by Molmil
Irak4-inhibitor co-structure
分子名称: Interleukin-1 receptor-associated kinase 4, ~{N}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide
著者Fischmann, T.O.
登録日2016-07-20
公開日2016-08-17
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
4U9A
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BU of 4u9a by Molmil
Sulphur Anomalous Crystal Structure of Asymmetric IRAK4 Dimer
分子名称: Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
著者Ferrao, R, Liu, Q, Wu, H.
登録日2014-08-05
公開日2014-09-24
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
5W84
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CRYSTAL STRUCTURE OF IRAK-4 WITH A 4,6-DIAMINONICOTINAMIDE INHIBITOR (COMPOUND NUMBER 4)
分子名称: 4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]pyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4
著者Sack, J.S.
登録日2017-06-21
公開日2017-10-11
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
8V1O
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BU of 8v1o by Molmil
Crystal structure of IRAK4 kinase domain with compound 4
分子名称: CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ...
著者Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N.
登録日2023-11-21
公開日2024-07-03
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
J.Med.Chem., 67, 2024
7QG2
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BU of 7qg2 by Molmil
IRAK4 in complex with inhibitor
分子名称: 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one, Interleukin-1 receptor-associated kinase 4
著者Xue, Y, Aagaard, A, Robb, G.R, Degorce, S.L.
登録日2021-12-07
公開日2022-05-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.031 Å)
主引用文献Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
Bioorg.Med.Chem., 63, 2022
7C2W
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Crystal Structure of IRAK4 kinase in complex with a small molecule inhibitor
分子名称: Interleukin-1 receptor-associated kinase 4, N-(2-morpholin-4-yl-1,3-benzoxazol-6-yl)-6-pyridin-4-yl-pyridine-2-carboxamide
著者Krishnamurthy, N.R, Anirudha, L.
登録日2020-05-09
公開日2020-11-25
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies.
Acs Med.Chem.Lett., 11, 2020
3MOP
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The ternary Death Domain complex of MyD88, IRAK4, and IRAK2
分子名称: Interleukin-1 receptor-associated kinase 4, Interleukin-1 receptor-associated kinase-like 2, Myeloid differentiation primary response protein MyD88
著者Lin, S.-C, Lo, Y.-C, Wu, H.
登録日2010-04-23
公開日2010-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
Nature, 465, 2010
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