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PDB: 12 件
8CR4
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BU of 8cr4 by Molmil
Crystal structure of recombinant LasBArtif from Pseudomonas aeruginosa AZPAE14816
分子名称: CALCIUM ION, Pro-elastase, ZINC ION
著者Kolling, D, Koehnke, J.
登録日2023-03-07
公開日2023-07-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (0.91 Å)
主引用文献Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in Escherichia coli for Structure-Based Drug Design.
Chembiochem, 24, 2023
8CR3
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BU of 8cr3 by Molmil
Crystal structure of recombinant LasB from Pseudomonas aeruginosa PAO1
分子名称: CALCIUM ION, Pro-elastase, ZINC ION
著者Kolling, D, Koehnke, J.
登録日2023-03-07
公開日2023-07-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in Escherichia coli for Structure-Based Drug Design.
Chembiochem, 24, 2023
6F8B
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BU of 6f8b by Molmil
LasB bound to thiol based inhibitor
分子名称: CALCIUM ION, Elastase, ZINC ION, ...
著者Koehnke, J, Sikandar, A.
登録日2017-12-12
公開日2018-03-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.
ACS Infect Dis, 4, 2018
1U4G
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BU of 1u4g by Molmil
Elastase of Pseudomonas aeruginosa with an inhibitor
分子名称: CALCIUM ION, Elastase, N-(1-CARBOXY-3-PHENYLPROPYL)PHENYLALANYL-ALPHA-ASPARAGINE, ...
著者Bitto, E, McKay, D.B.
登録日2004-07-25
公開日2004-08-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Elastase of Pseudomonas aeruginosa with an inhibitor
To be Published, 2004
3DBK
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BU of 3dbk by Molmil
Pseudomonas aeruginosa elastase with phosphoramidon
分子名称: CALCIUM ION, Elastase, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, ...
著者McKay, D.B, Overgaard, M.T.
登録日2008-06-01
公開日2009-07-07
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of the Elastase of Pseudomonas aeruginosa Complexed with Phosphoramidon
To be Published
1EZM
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BU of 1ezm by Molmil
THREE-DIMENSIONAL STRUCTURE OF THE ELASTASE OF PSEUDOMONAS AERUGINOSA AT 1.5 ANGSTROMS RESOLUTION
分子名称: CALCIUM ION, PSEUDOMONAS ELASTASE, ZINC ION
著者Thayer, M.M, Flaherty, K.M, Mckay, D.B.
登録日1992-01-13
公開日1993-10-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Three-dimensional structure of the elastase of Pseudomonas aeruginosa at 1.5-A resolution.
J.Biol.Chem., 266, 1991
7Z68
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BU of 7z68 by Molmil
Pseudomonas aeruginosa Elastase in complex with a Thiol based inhibitor (R-and S-configured)
分子名称: (2~{R})-~{N}-[4-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanylphenyl]-3-phenyl-2-sulfanyl-propanamide, CALCIUM ION, GLYCEROL, ...
著者Klein, A, Hirsch, A.
登録日2022-03-11
公開日2023-09-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Dual inhibitors of Pseudomonas aeruginosa virulence factors LecA and LasB
To Be Published
8CR7
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BU of 8cr7 by Molmil
Crystal structure of recombinant LasB from Pseudomonas aeruginosa PA7
分子名称: CALCIUM ION, Pro-elastase, ZINC ION
著者Kolling, D, Koehnke, J.
登録日2023-03-07
公開日2023-07-05
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in Escherichia coli for Structure-Based Drug Design.
Chembiochem, 24, 2023
7OC7
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BU of 7oc7 by Molmil
LasB, alpha-alkyl-N-aryl mercaptoacetamide
分子名称: (2R)-N,3-diphenyl-2-sulfanyl-propanamide, CALCIUM ION, Neutral metalloproteinase, ...
著者Koehnke, J, Sikandar, A.
登録日2021-04-26
公開日2022-01-19
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Angew.Chem.Int.Ed.Engl., 61, 2022
6FZX
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BU of 6fzx by Molmil
LasB, hydroxymate Inhibitor Complex
分子名称: CALCIUM ION, GLYCEROL, Keratinase KP2, ...
著者Koehnke, J, Sikandar, A.
登録日2018-03-15
公開日2018-09-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.
ACS Chem. Biol., 13, 2018
8CC4
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BU of 8cc4 by Molmil
LasB bound to phosphonic acid based inhibitor
分子名称: CALCIUM ION, Elastase, ZINC ION, ...
著者Mueller, R, Sikandar, A.
登録日2023-01-26
公開日2023-12-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections.
Acs Cent.Sci., 9, 2023
7QH1
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BU of 7qh1 by Molmil
Discovery and development of a novel inhaled antivirulence therapy for the treatment of Pseudomonas aeruginosa infections in patients with chronic respiratory disease
分子名称: 2-[2-[[5-[3-[bis(2-hydroxyethyl)-methyl-$l^{4}-azanyl]propoxy]-6-methoxy-1,3-benzothiazol-2-yl]methylcarbamoyl]-5,6-bis(fluoranyl)-1,3-dihydroinden-2-yl]ethanoic acid, CALCIUM ION, Keratinase KP2, ...
著者Leonard, P.M, Davies, D, Pallin, T.D.
登録日2021-12-10
公開日2022-12-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1 beta in Cellular and Animal Infection Models.
Acs Infect Dis., 9, 2023

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件を2024-07-10に公開中

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