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PDB: 26 件
3CC6
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Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B)
分子名称: GLYCEROL, MAGNESIUM ION, Protein tyrosine kinase 2 beta
著者Busam, R.D, Lehtio, L, Karlberg, T, Arrowsmith, C.H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Helleday, T, Herman, M.D, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Weigelt, J, Welin, M, Berglund, H, Structural Genomics Consortium (SGC)
登録日2008-02-25
公開日2008-03-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of Protein Tyrosine Kinase 2 Beta (PTK2B) Kinase domain.
To be Published
3FZS
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BU of 3fzs by Molmil
Crystal Structure of PYK2 complexed with BIRB796
分子名称: 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA, Protein tyrosine kinase 2 beta
著者Han, S.
登録日2009-01-26
公開日2009-03-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
4XEK
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BU of 4xek by Molmil
Pyk2-FAT domain in complex with leupaxin LD4 motif
分子名称: 19-mer peptide containing Leupaxin LD4 motif, Protein-tyrosine kinase 2-beta
著者Miller, D.J.
登録日2014-12-24
公開日2015-12-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.793 Å)
主引用文献Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Biochemistry, 55, 2016
8XOX
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BU of 8xox by Molmil
The Crystal Structure of FAK2 from Biortus.
分子名称: 1,2-ETHANEDIOL, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide, Protein-tyrosine kinase 2-beta
著者Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J.
登録日2024-01-02
公開日2024-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Crystal Structure of FAK2 from Biortus.
To Be Published
3FZT
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BU of 3fzt by Molmil
Crystal structure of PYK2 complexed with PF-4618433
分子名称: 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3H-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1H-pyrazol-5-yl}urea, Protein tyrosine kinase 2 beta
著者Han, S.
登録日2009-01-26
公開日2009-03-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
5TO8
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BU of 5to8 by Molmil
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
分子名称: 25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22,23,24,25-octahydro-12H-7,11-(azeno)-16,13-(metheno)pyrido[3,2-i]pyrrolo[1,2-q][1,3,7,11,17]pentaazacyclohenicosin-20(6H)-one, Protein-tyrosine kinase 2-beta
著者Newby, Z.E.
登録日2016-10-17
公開日2016-12-21
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.9849 Å)
主引用文献Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Bioorg. Med. Chem. Lett., 26, 2016
4H1M
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Crystal structure of PYK2 with the indole 10c
分子名称: 7-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)-N-(propan-2-yl)-1H-indole-2-carboxamide, Protein-tyrosine kinase 2-beta
著者Han, S.
登録日2012-09-10
公開日2012-11-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
8YGX
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Structure of the PYK2 from Biortus.
分子名称: Protein-tyrosine kinase 2-beta
著者Wang, F, Cheng, W, Lv, Z, Meng, Q, Zhang, B.
登録日2024-02-27
公開日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the PYK2 from Biortus.
To Be Published
3H3C
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BU of 3h3c by Molmil
Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog
分子名称: 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide, Protein tyrosine kinase 2 beta, SULFATE ION
著者Han, S, Mistry, A.
登録日2009-04-16
公開日2009-05-26
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Bioorg.Med.Chem.Lett., 19, 2009
4H1J
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Crystal structure of PYK2 with the pyrazole 13a
分子名称: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1H-pyrazol-5-yl]urea, Protein-tyrosine kinase 2-beta
著者Han, S.
登録日2012-09-10
公開日2012-11-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4XEV
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BU of 4xev by Molmil
Fusion of Pyk2-FAT domain with Leupaxin LD1 motif, complexed with Leupaxin LD4 peptide
分子名称: 19-mer peptide containing Leupaxin LD4 motif, Fusion protein of Protein-tyrosine kinase 2-beta FAT domain and Leupaxin LD1 motif
著者Miller, D.J.
登録日2014-12-24
公開日2015-12-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.0073 Å)
主引用文献Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Biochemistry, 55, 2016
3FZP
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BU of 3fzp by Molmil
Crystal structure of PYK2 complexed with ATPgS
分子名称: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Protein tyrosine kinase 2 beta, SULFATE ION
著者Han, S.
登録日2009-01-26
公開日2009-03-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
5TOB
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BU of 5tob by Molmil
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
分子名称: N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide, Protein-tyrosine kinase 2-beta
著者Newby, Z.E.
登録日2016-10-17
公開日2017-11-29
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.117 Å)
主引用文献Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Bioorg. Med. Chem. Lett., 26, 2016
3FZO
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BU of 3fzo by Molmil
Crystal Structure of PYK2-Apo, Proline-rich Tyrosine Kinase
分子名称: Protein tyrosine kinase 2 beta
著者Han, S.
登録日2009-01-26
公開日2009-03-31
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
4XEF
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BU of 4xef by Molmil
Pyk2-FAT complexed with Leupaxin LD motif LD1
分子名称: 20-mer peptide containing LD1 motif of leupaxin, Protein-tyrosine kinase 2-beta
著者Miller, D.J.
登録日2014-12-23
公開日2015-12-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Biochemistry, 55, 2016
3GM3
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BU of 3gm3 by Molmil
Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2
分子名称: Protein tyrosine kinase 2 beta
著者Lulo, J.E, Yuzawa, S, Schlessinger, J.
登録日2009-03-12
公開日2009-05-05
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Biochem.Biophys.Res.Commun., 383, 2009
3ET7
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BU of 3et7 by Molmil
Crystal structure of PYK2 complexed with PF-2318841
分子名称: 5-{[4-{[2-(pyrrolidin-1-ylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,3-dihydro-2H-indol-2-one, PHOSPHATE ION, Protein tyrosine kinase 2 beta
著者Han, S.
登録日2008-10-07
公開日2009-06-23
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
Bioorg.Med.Chem.Lett., 18, 2008
3FZR
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BU of 3fzr by Molmil
Crystal structure of PYK2 complexed with PF-431396
分子名称: N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide, PHOSPHATE ION, Protein tyrosine kinase 2 beta
著者Han, S.
登録日2009-01-26
公開日2009-03-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
3GM2
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BU of 3gm2 by Molmil
Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2
分子名称: Protein tyrosine kinase 2 beta
著者Lulo, J.E, Yuzawa, S, Schlessinger, J.
登録日2009-03-12
公開日2009-05-05
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Biochem.Biophys.Res.Commun., 383, 2009
3GM1
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Crystal Structure of the Focal Adhesion Targeting (FAT) Domain of Pyk2 in Complex with Paxillin LD4 Motif-Derived Peptides
分子名称: Paxillin, Protein tyrosine kinase 2 beta
著者Lulo, J.E, Yuzawa, S, Schlessinger, J.
登録日2009-03-12
公開日2009-05-05
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Biochem.Biophys.Res.Commun., 383, 2009
3U3F
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Structural basis for the interaction of Pyk2 PAT domain with paxillin LD motifs
分子名称: Paxillin LD2 peptide, Protein-tyrosine kinase 2-beta
著者Vanarotti, M, Miller, D.J, Guibao, C.C, Zheng, J.J.
登録日2011-10-05
公開日2012-10-24
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs.
J.Mol.Biol., 426, 2014
6LF3
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BU of 6lf3 by Molmil
3D domain-swapped dimer of the maltose-binding protein fused to a fragment of the protein-tyrosine kinase 2-beta
分子名称: Maltose/maltodextrin-binding periplasmic protein,Protein-tyrosine kinase 2-beta, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
著者Momin, A.A, Shahul Hameed, U.F, Arold, S.T.
登録日2019-11-28
公開日2019-12-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Passenger sequences can promote interlaced dimers in a common variant of the maltose-binding protein.
Sci Rep, 9, 2019
4EKU
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BU of 4eku by Molmil
Crystal Structure of FERM Domain of Proline-rich Tyrosine Kinase 2
分子名称: Protein-tyrosine kinase 2-beta
著者Savarimuthu, B, Li, R, Wang, Y.
登録日2012-04-09
公開日2012-04-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Crystal Structure of the Ferm Domain of Proline-rich Tyrosine Kinase 2
To be Published
4R32
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BU of 4r32 by Molmil
Crystal Structure Analysis of Pyk2 and Paxillin LD motifs
分子名称: Paxillin, Protein-tyrosine kinase 2-beta
著者Vanarotti, M, Miller, D.J, Guibao, C.D, Nourse, A, Zheng, J.J.
登録日2014-08-13
公開日2014-09-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.505 Å)
主引用文献Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs.
J.Mol.Biol., 426, 2014
2LK4
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Structural and mechanistic insights into the interaction between PAT Pyk2 and Paxillin LD motif
分子名称: Protein-tyrosine kinase 2-beta
著者Vanarotti, M, Miller, D, Guibao, C, Zheng, J.
登録日2011-10-04
公開日2012-10-10
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs.
J.Mol.Biol., 426, 2014

 

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