3L8W
 
 | | Urate oxidase from aspergillus flavus complexed with xanthin | | 分子名称: | SODIUM ION, Uricase, XANTHINE, ... | | 著者 | Prange, T, Gabison, L, Colloc'h, N, Chiadmi, M. | | 登録日 | 2010-01-04 | | 公開日 | 2010-06-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
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4N9S
 | | High resolution X-RAY STRUCTURE OF URATE OXIDASE IN COMPLEX WITH 8-HYDROXYXANTHINE | | 分子名称: | 8-hydroxy-3,9-dihydro-1H-purine-2,6-dione, CHLORIDE ION, GLYCEROL, ... | | 著者 | Oksanen, E, Blakeley, M.P, Budayova-Spano, M. | | 登録日 | 2013-10-21 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation.
Plos One, 9, 2014
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4POE
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4N9V
 | | High resolution x-ray structure of urate oxidase in complex with 8-azaxanthine | | 分子名称: | 8-AZAXANTHINE, CHLORIDE ION, GLYCEROL, ... | | 著者 | Oksanen, E, Blakeley, M.P, Budayova-Spano, M. | | 登録日 | 2013-10-21 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | The neutron structure of urate oxidase resolves a long-standing mechanistic conundrum and reveals unexpected changes in protonation.
Plos One, 9, 2014
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6IC1
 | | urate oxidase under 90 bar of krypton | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-AZAXANTHINE, ACETATE ION, ... | | 著者 | Prange, T, Colloc'h, N, Carpentier, P. | | 登録日 | 2018-12-01 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
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4PR8
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4CW6
 | | Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-metyl uric acid (X-ray dose, 92 kGy) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, 9-METHYL URIC ACID, ... | | 著者 | Bui, S, Steiner, R.A. | | 登録日 | 2014-04-01 | | 公開日 | 2014-10-29 | | 最終更新日 | 2018-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
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4OQC
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4PUV
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4D13
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4D17
 | | Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 106 kGy) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(HYDRO)PEROXOISOURATE, OXYGEN MOLECULE, ... | | 著者 | Bui, S, Steiner, R.A. | | 登録日 | 2014-05-01 | | 公開日 | 2014-11-05 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
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4CW2
 | | Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-metyl uric acid (X-ray dose, 2.5 kGy) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, URICASE | | 著者 | Bui, S, Steiner, R.A. | | 登録日 | 2014-04-01 | | 公開日 | 2014-10-29 | | 最終更新日 | 2018-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
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7A0L
 | | Joint neutron/X-ray room temperature structure of perdeuterated Aspergillus flavus urate oxidase in complex with the 8-azaxanthine inhibitor and catalytic water bound in the peroxo hole | | 分子名称: | 8-AZAXANTHINE, SODIUM ION, Uricase | | 著者 | McGregor, L, Bui, S, Blakeley, M.P, Steiner, R.A. | | 登録日 | 2020-08-09 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | NEUTRON DIFFRACTION (1.33 Å), X-RAY DIFFRACTION | | 主引用文献 | Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.
Iucrj, 8, 2021
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4CW3
 | | Crystal structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-metyl uric acid (X-ray dose, 665 kGy) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, (5S)-5-(dioxidanyl)-9-methyl-7H-purine-2,6,8-trione, 9-METHYL URIC ACID, ... | | 著者 | Bui, S, Steiner, R.A. | | 登録日 | 2014-04-01 | | 公開日 | 2014-10-29 | | 最終更新日 | 2018-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
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3LD4
 | | Urate oxidase complexed with 8-nitro xanthine | | 分子名称: | 1,2-ETHANEDIOL, 8-nitro-3,7-dihydro-1H-purine-2,6-dione, SODIUM ION, ... | | 著者 | Prange, T, Colloc'h, N, Gabison, L. | | 登録日 | 2010-01-12 | | 公開日 | 2010-06-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
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4D19
 | | Crystal structure of cofactor-free urate oxidase in complex with its 5-peroxoisourate intermediate (X-ray dose, 1.75 MGy) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(HYDRO)PEROXOISOURATE, OXYGEN MOLECULE, ... | | 著者 | Bui, S, Steiner, R.A. | | 登録日 | 2014-05-01 | | 公開日 | 2014-10-29 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Angew. Chem. Int. Ed. Engl., 53, 2014
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4D12
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5FRC
 | | Structure of urate oxidase prepared by the 'soak-and-freeze' method under 42 bar of oxygen pressure | | 分子名称: | 8-AZAXANTHINE, OXYGEN MOLECULE, SODIUM ION, ... | | 著者 | Lafumat, B, Mueller-Dieckmann, C, Colloc'h, N, Prange, T, Royant, A, van der Linden, P, Carpentier, P. | | 登録日 | 2015-12-16 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.443 Å) | | 主引用文献 | Gas-Sensitive Biological Crystals Processed in Pressurized Oxygen and Krypton Atmospheres: Deciphering Gas Channels in Proteins Using a Novel `Soak-and-Freeze' Methodology.
J.Appl.Crystallogr., 49, 2016
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3P9O
 | | Aerobic ternary complex of urate oxidase with azide and chloride | | 分子名称: | AZIDE ION, CHLORIDE ION, SODIUM ION, ... | | 著者 | Gabison, L, Colloc'H, N, El Hajji, M, Castro, B, Chiadmi, M, Prange, T. | | 登録日 | 2010-10-18 | | 公開日 | 2011-08-31 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Azide and Cyanide Show Different Inhibition Modes to Urate Oxidase
To be Published
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2IBA
 | | Urate oxidase from Aspergillus flavus complexed with its inhibitor 8-azaxanthine | | 分子名称: | 8-AZAXANTHINE, SODIUM ION, Uricase | | 著者 | Colloc'h, N, Retailleau, P, Sopkova-de Oliveira Santos, J, Prange, T. | | 登録日 | 2006-09-11 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Protein Crystallography under Xenon and Nitrous Oxide Pressure: Comparison with In Vivo Pharmacology Studies and Implications for the Mechanism of Inhaled Anesthetic Action
Biophys.J., 92, 2007
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6RGM
 | | urate oxidase under 130 bar of krypton | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 8-AZAXANTHINE, ACETATE ION, ... | | 著者 | Prange, T, Colloc'h, N, Carpentier, P. | | 登録日 | 2019-04-17 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization
Acta Cryst. D, 78, 2022
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3OBP
 | | Anaerobic complex of urate oxidase with uric acid | | 分子名称: | SODIUM ION, URIC ACID, Uricase | | 著者 | Gabison, L, Chopard, C, Colloc'h, N, El Hajji, M, Castro, B, Chiadmi, M, Prange, T. | | 登録日 | 2010-08-08 | | 公開日 | 2011-06-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | X-ray, ESR, and quantum mechanics studies unravel a spin well in the cofactor-less urate oxidase.
Proteins, 79, 2011
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3LBG
 | | Urate oxidase complexed with 8-thio xanthine | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 8-thioxo-3,7,8,9-tetrahydro-1H-purine-2,6-dione, ... | | 著者 | Prange, T, Colloc'h, N, Gabison, L. | | 登録日 | 2010-01-08 | | 公開日 | 2010-06-02 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand.
Acta Crystallogr.,Sect.D, 66, 2010
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4CW0
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4OP9
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