4F4J
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![BU of 4f4j by Molmil](/molmil-images/mine/4f4j) | Conversion of the enzyme guanylate kinase into a mitotic spindle orienting protein by a single mutation that inhibits gmp- induced closing | 分子名称: | Guanylate kinase, SULFATE ION | 著者 | Johnston, C.A, Whitney, D, Volkman, B.F, Prehoda, K.E. | 登録日 | 2012-05-10 | 公開日 | 2012-06-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. Proc.Natl.Acad.Sci.USA, 108, 2011
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7S5E
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2J41
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![BU of 2j41 by Molmil](/molmil-images/mine/2j41) | Crystal structure of Staphylococcus aureus guanylate monophosphate kinase | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, GUANYLATE KINASE, POTASSIUM ION, ... | 著者 | El Omari, K, Dhaliwal, B, Lockyer, M, Charles, I, Hawkins, A.R, Stammers, D.K. | 登録日 | 2006-08-24 | 公開日 | 2006-10-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of Staphylococcus Aureus Guanylate Monophosphate Kinase Acta Crystallogr.,Sect.F, 62, 2006
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8PTS
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![BU of 8pts by Molmil](/molmil-images/mine/8pts) | human GUK1 in complex with compound AT8001 | 分子名称: | GLYCEROL, Guanylate kinase, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | 著者 | Zimberger, C, Canard, B, Ferron, F. | 登録日 | 2023-07-14 | 公開日 | 2024-07-24 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution. Plos Biol., 22, 2024
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4QRH
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![BU of 4qrh by Molmil](/molmil-images/mine/4qrh) | Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp | 分子名称: | 1,2-ETHANEDIOL, Guanylate kinase, MAGNESIUM ION, ... | 著者 | Liu, K, Krasny, K, Myers, A.R, Satyshur, K.A, Keck, J.L, Wnag, J.D. | 登録日 | 2014-07-01 | 公開日 | 2015-02-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Molecular Mechanism and Evolution of Guanylate Kinase Regulation by (p)ppGpp. Mol.Cell, 57, 2015
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6WCT
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6MFU
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5YPO
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![BU of 5ypo by Molmil](/molmil-images/mine/5ypo) | Crystal structure of PSD-95 GK domain in complex with phospho-SAPAP peptide | 分子名称: | Disks large homolog 4, GLYCEROL, SAPAP | 著者 | Zhu, J, Zhou, Q, Shang, Y, Weng, Z, Zhang, R, Zhang, M. | 登録日 | 2017-11-02 | 公開日 | 2018-03-14 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. Cell Rep, 21, 2017
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7F7G
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![BU of 7f7g by Molmil](/molmil-images/mine/7f7g) | a linear Peptide Inhibitors in complex with GK domain | 分子名称: | DLG4 GK domain, UNK-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYS-ALA-ILE-GLN-UNK | 著者 | Shang, Y, Huang, X, Li, X, Zhang, M. | 登録日 | 2021-06-29 | 公開日 | 2022-02-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.446 Å) | 主引用文献 | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. Rsc Chem Biol, 2, 2021
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7F7I
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![BU of 7f7i by Molmil](/molmil-images/mine/7f7i) | Stapled Peptide Inhibitor in complex with PSD95 GK domain | 分子名称: | ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2, Disks large homolog 4 | 著者 | Shang, Y, Huang, X, Li, X, Zhang, M. | 登録日 | 2021-06-29 | 公開日 | 2022-04-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.595 Å) | 主引用文献 | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. Rsc Chem Biol, 2, 2021
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6NUI
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![BU of 6nui by Molmil](/molmil-images/mine/6nui) | Human Guanylate Kinase | 分子名称: | Guanylate kinase | 著者 | Sabo, T.M, Khan, N, Ban, D, Trigo-Mourino, P, Carneiro, M.G, Trent, J.O, Konrad, M, Lee, D. | 登録日 | 2019-02-01 | 公開日 | 2019-06-26 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer. J.Biol.Chem., 294, 2019
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2QOR
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3LNC
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3W9Y
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![BU of 3w9y by Molmil](/molmil-images/mine/3w9y) | Crystal structure of the human DLG1 guanylate kinase domain | 分子名称: | Disks large homolog 1 | 著者 | Mori, S, Tezuka, Y, Arakawa, A, Handa, N, Shirouzu, M, Akiyama, T, Yokoyama, S. | 登録日 | 2013-04-18 | 公開日 | 2013-06-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97) Biochem.Biophys.Res.Commun., 435, 2013
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3WP0
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![BU of 3wp0 by Molmil](/molmil-images/mine/3wp0) | Crystal structure of Dlg GK in complex with a phosphor-Lgl2 peptide | 分子名称: | Disks large homolog 4, GLYCEROL, Lethal(2) giant larvae protein homolog 2 | 著者 | Zhu, J, Shang, Y, Wan, Q, Xia, Y, Chen, J, Du, Q, Zhang, M. | 登録日 | 2014-01-08 | 公開日 | 2014-03-19 | 最終更新日 | 2014-04-30 | 実験手法 | X-RAY DIFFRACTION (2.039 Å) | 主引用文献 | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl Cell Res., 24, 2014
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3WP1
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![BU of 3wp1 by Molmil](/molmil-images/mine/3wp1) | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl | 分子名称: | Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, SULFATE ION | 著者 | Zhu, J, Shang, Y, Wan, Q, Xia, Y, Chen, J, Du, Q, Zhang, M. | 登録日 | 2014-01-08 | 公開日 | 2014-03-19 | 最終更新日 | 2014-04-30 | 実験手法 | X-RAY DIFFRACTION (2.804 Å) | 主引用文献 | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl Cell Res., 24, 2014
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5GNV
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![BU of 5gnv by Molmil](/molmil-images/mine/5gnv) | Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain | 分子名称: | Disks large homolog 4, Microtubule-associated protein 1A, SULFATE ION | 著者 | Shang, Y, Xia, Y, Zhu, R, Zhu, J. | 登録日 | 2016-07-25 | 公開日 | 2017-08-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.596 Å) | 主引用文献 | Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain Biochem. J., 474, 2017
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2AN9
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![BU of 2an9 by Molmil](/molmil-images/mine/2an9) | Crystal Structure Of Oligomeric E.coli Guanylate Kinase In Complex With GDP | 分子名称: | GUANOSINE, GUANOSINE-5'-DIPHOSPHATE, Guanylate kinase, ... | 著者 | Hible, G, Renault, L, Schaeffer, F, Christova, P, Radulescu, A.Z, Evrin, C, Gilles, A.M, Cherfils, J. | 登録日 | 2005-08-11 | 公開日 | 2005-08-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Calorimetric and crystallographic analysis of the oligomeric structure of Escherichia coli GMP kinase J.Mol.Biol., 352, 2005
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1GKY
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3NEY
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![BU of 3ney by Molmil](/molmil-images/mine/3ney) | Crystal structure of the kinase domain of MPP1/p55 | 分子名称: | 55 kDa erythrocyte membrane protein, SULFATE ION, UNKNOWN ATOM OR ION | 著者 | Shen, Y, Tong, Y, Zhong, N, Guan, X, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-06-09 | 公開日 | 2010-08-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Crystal structure of the kinase domain of MPP1/p55 To be Published
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2F3T
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2F3R
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1EX7
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1EX6
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7LUY
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