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PDB: 80 件
1NO3
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REFINED STRUCTURE OF SOYBEAN LIPOXYGENASE-3 WITH 4-NITROCATECHOL AT 2.15 ANGSTROM RESOLUTION
分子名称: 4-NITROCATECHOL, FE (III) ION, Lipoxygenase-3
著者Skrzypczak-Jankun, E, Borbulevych, O.Y, Jankun, J.
登録日2003-01-15
公開日2003-06-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Soybean lipoxygenase-3 in complex with 4-nitrocatechol.
Acta Crystallogr.,Sect.D, 60, 2004
5TQP
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LIPOXYGENASE-1 (SOYBEAN) I553G MUTANT AT 300K
分子名称: FE (III) ION, Seed linoleate 13S-lipoxygenase-1
著者Poss, E.M, Fraser, J.S.
登録日2016-10-24
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.
ACS Cent Sci, 3, 2017
8GHE
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The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA
分子名称: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
著者Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
登録日2023-03-09
公開日2023-08-09
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (2.05 Å)
主引用文献Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
8GHB
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The structure of h12-LOX in monomeric form
分子名称: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12
著者Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
登録日2023-03-09
公開日2023-08-09
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
8GHD
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The structure of h12-LOX in hexameric form bound to inhibitor ML355 and arachidonic acid
分子名称: ARACHIDONIC ACID, FE (II) ION, N-(1,3-benzothiazol-2-yl)-4-{[(2-hydroxy-3-methoxyphenyl)methyl]amino}benzene-1-sulfonamide, ...
著者Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
登録日2023-03-09
公開日2023-08-09
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
8GHC
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The structure of h12-LOX in dimeric form
分子名称: FE (II) ION, Polyunsaturated fatty acid lipoxygenase ALOX12
著者Black, K.A, Mobbs, J.I, Venugopal, H, Thal, D.M, Glukhova, A.
登録日2023-03-09
公開日2023-08-09
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood, 142, 2023
5TQO
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Lipoxygenase-1 (soybean) L546A/L754A mutant at 300K
分子名称: FE (III) ION, Seed linoleate 13S-lipoxygenase-1
著者Poss, E.M, Fraser, J.S, Gee, C.
登録日2016-10-24
公開日2017-11-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.
J.Am.Chem.Soc., 141, 2019
5EEO
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soybean lipoxygenase(L1)-T756R
分子名称: FE (II) ION, Seed linoleate 13S-lipoxygenase-1
著者Mikami, B, Nagaya, T, Hioki, Y.
登録日2015-10-23
公開日2015-11-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The structural basis for specificity in lipoxygenase catalysis
To Be Published
3VF1
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Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca-regulation
分子名称: 11R-lipoxygenase, FE (II) ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose
著者Eek, P, Jarving, R, Jarving, I, Gilbert, N.C, Newcomer, M.E, Samel, N.
登録日2012-01-09
公開日2012-05-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.473 Å)
主引用文献Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation.
J.Biol.Chem., 287, 2012
1LOX
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RABBIT RETICULOCYTE 15-LIPOXYGENASE
分子名称: (2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID, 15-LIPOXYGENASE, FE (II) ION
著者Gillmor, S.A, Villasenor, A, Fletterick, R.J, Sigal, E, Browner, M.F.
登録日1997-10-06
公開日1998-11-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.
Nat.Struct.Biol., 4, 1997
1LNH
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LIPOXYGENASE-3(SOYBEAN) NON-HEME FE(II) METALLOPROTEIN
分子名称: FE (II) ION, LIPOXYGENASE-3
著者Skrzypczak-Jankun, E.
登録日1996-03-29
公開日1997-02-02
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme.
Proteins, 29, 1997
1JNQ
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LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)
分子名称: 2-(3,4,5-TRIHYDROXY-PHENYL)-CHROMAN-3,5,7-TRIOL, FE (II) ION, lipoxygenase-3
著者Zhou, K, Skrzypczak-Jankun, E, Jankun, J.
登録日2001-07-24
公開日2003-06-03
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.
INT.J.MOL.MED., 12, 2003
1RRH
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Soybean Lipoxygenase (LOX-3) at ambient temperatures at 2.0 A resolution
分子名称: FE (II) ION, Seed lipoxygenase-3
著者Borbulevych, O.Y, Jankun, J, Skrzypczak-Jankun, E.
登録日2003-12-08
公開日2004-12-21
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Effect of crystal freezing and small-molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 A resolution.
Acta Crystallogr.,Sect.D, 62, 2006
1ROV
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BU of 1rov by Molmil
Lipoxygenase-3 Treated with Cumene Hydroperoxide
分子名称: FE (III) ION, Seed lipoxygenase-3
著者Vahedi-Faridi, A, Brault, P.A, Shah, P, Kim, Y.W, Dunham, W.R, Funk, M.O.
登録日2003-12-02
公開日2004-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Interaction between non-heme iron of lipoxygenases and cumene hydroperoxide: basis for enzyme activation, inactivation, and inhibition
J.Am.Chem.Soc., 126, 2004
1FGT
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q697N MUTANT
分子名称: FE (III) ION, SEED LIPOXYGENASE-1
著者Tomchick, D.R, Minor, W, Holman, T.
登録日2000-07-28
公開日2001-07-04
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1F8N
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, NEW REFINEMENT
分子名称: FE (II) ION, LIPOXYGENASE-1
著者Tomchick, D.R, Minor, W, Holman, T.
登録日2000-06-30
公開日2001-07-04
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGM
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, N694H MUTANT
分子名称: FE (III) ION, SEED LIPOXYGENASE-1
著者Tomchick, D.R, Minor, W, Holman, T.R.
登録日2000-07-28
公開日2001-10-24
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGQ
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q495E MUTANT
分子名称: FE (III) ION, SEED LIPOXYGENASE-1
著者Tomchick, D.R, Minor, W, Holman, T.
登録日2000-07-28
公開日2001-07-04
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
1FGR
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LIPOXYGENASE-1 (SOYBEAN) AT 100K, Q697E MUTANT
分子名称: FE (III) ION, SEED LIPOXYGENASE-1
著者Tomchick, D.R, Minor, W, Holman, T.
登録日2000-07-28
公開日2001-07-04
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and functional characterization of second-coordination sphere mutants of soybean lipoxygenase-1.
Biochemistry, 40, 2001
7SOI
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BU of 7soi by Molmil
Structure of I552A Soybean Lipoxygenase at 277K
分子名称: FE (III) ION, Lipoxygenase, SODIUM ION
著者Gee, C.L, Offenbacher, A.R, Hu, S.
登録日2021-10-31
公開日2022-11-09
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.
Proc.Natl.Acad.Sci.USA, 120, 2023
7SOJ
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Structure of V750A Soybean Lipoxygenase at 277K
分子名称: FE (III) ION, Lipoxygenase
著者Gee, C.L, Offenbacher, A.R, Hu, S.
登録日2021-10-31
公開日2022-11-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.
Proc.Natl.Acad.Sci.USA, 120, 2023
7TTL
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Stable-5-LOX elongated Ha2 (4 copies ASU)
分子名称: Arachidonate 5-lipoxygenase, FE (II) ION
著者Gilbert, N.C, Newcomer, M.E.
登録日2022-02-01
公開日2022-08-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators.
J.Biol.Chem., 298, 2022
7TTJ
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Stable-5-LOX elongated Ha2
分子名称: Arachidonate 5-lipoxygenase, FE (II) ION
著者Gilbert, N.C, Newcomer, M.E.
登録日2022-02-01
公開日2022-08-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators.
J.Biol.Chem., 298, 2022
7TTK
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Stable-5-LOX
分子名称: Arachidonate 5-lipoxygenase, FE (II) ION
著者Gilbert, N.C, Newcomer, M.E.
登録日2022-02-01
公開日2023-02-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Stable-5-LOX "closed"
To Be Published
3FG1
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Crystal structure of Delta413-417:GS LOX
分子名称: ACETIC ACID, Allene oxide synthase-lipoxygenase protein, CALCIUM ION, ...
著者Neau, D.B, Newcomer, M.E.
登録日2008-12-04
公開日2009-08-18
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
Biochemistry, 48, 2009

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