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PDB: 302 件

7R3X
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BU of 7r3x by Molmil
The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ACETATE ION, CALCIUM ION, ...
著者Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
登録日2022-02-08
公開日2022-07-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Nucleic Acids Res., 50, 2022
7R3Y
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BU of 7r3y by Molmil
The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA Primer, ...
著者Barbari, S.R, Beach, A.K, Markgren, J.G, Parkash, V, Johansson, E, Shcherbakova, P.V.
登録日2022-02-08
公開日2022-07-27
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Nucleic Acids Res., 50, 2022
7RSR
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Kod-RI incorporating PMT, n+2
分子名称: DNA polymerase, Primer, Template
著者Hajjar, M, Chim, N, Chaput, J.C.
登録日2021-08-11
公開日2022-08-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Nucleic Acids Res., 50, 2022
7RSS
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Kod-RI incorporating DNA, n+2
分子名称: DNA polymerase, Primer, Template
著者Hajjar, M, Chim, N, Chaput, J.C.
登録日2021-08-11
公開日2022-08-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Nucleic Acids Res., 50, 2022
7RSU
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TNA polymerase, n+2 product
分子名称: DNA polymerase, Primer, Template
著者Maola, V, Chaput, J, Chim, N.
登録日2021-08-11
公開日2021-10-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities.
J.Am.Chem.Soc., 143, 2021
7QHS
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BU of 7qhs by Molmil
S. cerevisiae CMGE nucleating origin DNA melting
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ...
著者Lewis, J.S, Sousa, J.S, Costa, A.
登録日2021-12-14
公開日2022-06-15
最終更新日2022-07-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Mechanism of replication origin melting nucleated by CMG helicase assembly.
Nature, 606, 2022
5OMF
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BU of 5omf by Molmil
Closed, ternary structure of KOD DNA polymerase
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), ...
著者Kropp, H.M, Betz, K, Wirth, J, Diederichs, K, Marx, A.
登録日2017-07-31
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.092 Å)
主引用文献Crystal structures of ternary complexes of archaeal B-family DNA polymerases.
PLoS ONE, 12, 2017
5OMQ
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Ternary complex of 9N DNA polymerase in the replicative state with three metal ions in the active site
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA Primer, DNA Template, ...
著者Betz, K, Marx, A, Diederichs, K.
登録日2017-08-01
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Crystal structures of ternary complexes of archaeal B-family DNA polymerases.
PLoS ONE, 12, 2017
6S2F
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Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon (Class 2)
分子名称: Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, DNA polymerase epsilon catalytic subunit A, ...
著者Grabarczyk, D.B, Song, B.
登録日2019-06-20
公開日2020-07-08
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Ctf18-RFC and DNA Pol ε form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
Nucleic Acids Res., 48, 2020
6S2E
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Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon
分子名称: Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, DNA polymerase epsilon catalytic subunit A, ...
著者Grabarczyk, D.B, Song, B.
登録日2019-06-20
公開日2020-07-08
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Ctf18-RFC and DNA Pol ε form a stable leading strand polymerase/clamp loader complex required for normal and perturbed DNA replication.
Nucleic Acids Res., 48, 2020
6ISF
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BU of 6isf by Molmil
Structure of 9N-I DNA polymerase incorporation with dT in the active site
分子名称: CALCIUM ION, DNA (5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*T)-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-16
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6ISH
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BU of 6ish by Molmil
Structure of 9N-I DNA polymerase incorporation with 3'-AL in the active site
分子名称: CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*(DAL))-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-16
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6IS7
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BU of 6is7 by Molmil
Structure of 9N-I DNA polymerase incorporation with dA in the active site
分子名称: CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*A)-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-15
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6S1N
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BU of 6s1n by Molmil
Human polymerase delta holoenzyme Conformer 2
分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
著者Lancey, C, Hamdan, S.M, De Biasio, A.
登録日2019-06-19
公開日2019-12-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.86 Å)
主引用文献Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6S1O
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BU of 6s1o by Molmil
Human polymerase delta holoenzyme Conformer 3
分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
著者Lancey, C, Hamdan, S.M, De Biasio, A.
登録日2019-06-19
公開日2019-12-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (8.1 Å)
主引用文献Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6TNY
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BU of 6tny by Molmil
Processive human polymerase delta holoenzyme
分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
著者Lancey, C, Hamdan, S.M, De Biasio, A.
登録日2019-12-10
公開日2019-12-18
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.08 Å)
主引用文献Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6I8A
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BU of 6i8a by Molmil
The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R substitution.
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase epsilon catalytic subunit A, ...
著者Parkash, V, Johansson, E.
登録日2018-11-19
公開日2019-01-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.652 Å)
主引用文献Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Nat Commun, 10, 2019
6S1M
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BU of 6s1m by Molmil
Human polymerase delta holoenzyme Conformer 1
分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
著者Lancey, C, Hamdan, S.M, De Biasio, A.
登録日2019-06-19
公開日2019-12-25
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.27 Å)
主引用文献Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6ISG
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BU of 6isg by Molmil
Structure of 9N-I DNA polymerase incorporation with dG in the active site
分子名称: CALCIUM ION, DNA (5'-D(*GP*AP*CP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*CP*G)-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-16
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.401 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
6TNZ
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BU of 6tnz by Molmil
Human polymerase delta-FEN1-PCNA toolbelt
分子名称: DNA polymerase delta catalytic subunit, DNA polymerase delta subunit 2, DNA polymerase delta subunit 3, ...
著者Lancey, C, Hamdan, S.M, De Biasio, A.
登録日2019-12-10
公開日2019-12-18
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (4.05 Å)
主引用文献Structure of the processive human Pol delta holoenzyme.
Nat Commun, 11, 2020
6H1V
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BU of 6h1v by Molmil
The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S cluster
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(P*AP*AP*TP*TP*GP*AP*AP*CP*GP*CP*GP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*CP*GP*CP*GP*TP*TP*(DOC))-3'), ...
著者Parkash, V, Johansson, E.
登録日2018-07-12
公開日2019-04-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Nucleic Acids Res., 47, 2019
6ISI
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BU of 6isi by Molmil
Structure of 9N-I DNA polymerase incorporation with 3'-CL in the active site
分子名称: 3-[2-[2-(2-azanylethoxy)ethoxy]ethoxy]propanoic acid, CALCIUM ION, DNA (5'-D(P*AP*CP*GP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), ...
著者Linwu, S.W, Maestre-Reyna, M, Tsai, M.D, Tu, Y.H, Chang, W.H.
登録日2018-11-16
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Thermococcus sp. 9°N DNA polymerase exhibits 3'-esterase activity that can be harnessed for DNA sequencing.
Commun Biol, 2, 2019
7OM3
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BU of 7om3 by Molmil
Crystal structure of KOD DNA Polymerase in a binary complex with Hypoxanthine containing template
分子名称: 1,2-ETHANEDIOL, 21nt Template, BROMIDE ION, ...
著者Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
登録日2021-05-21
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7OMG
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BU of 7omg by Molmil
Crystal structure of KOD DNA Polymerase in a ternary complex with an Uracil containing template
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ...
著者Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
登録日2021-05-22
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7OMB
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BU of 7omb by Molmil
Crystal structure of KOD DNA Polymerase in a ternary complex with a p/t duplex containing an extended 5' single stranded template overhang
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, ...
著者Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
登録日2021-05-21
公開日2021-10-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021

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件を2024-06-12に公開中

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