6IW7
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![BU of 6iw7 by Molmil](/molmil-images/mine/6iw7) | structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease | 分子名称: | (2S)-2-benzamido-4-methyl-pentanoic acid, 4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline, ATP-dependent Clp protease proteolytic subunit 1, ... | 著者 | Bao, R, Luo, Y.F, Zhu, Y.B, Yang, Y, Zhou, Y.Z. | 登録日 | 2018-12-04 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.692121 Å) | 主引用文献 | structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease To Be Published
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5E0S
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![BU of 5e0s by Molmil](/molmil-images/mine/5e0s) | crystal structure of the active form of the proteolytic complex clpP1 and clpP2 | 分子名称: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2 | 著者 | LI, M, Wlodawer, A, Maurizi, M. | 登録日 | 2015-09-29 | 公開日 | 2016-02-17 | 最終更新日 | 2016-04-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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5DZK
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![BU of 5dzk by Molmil](/molmil-images/mine/5dzk) | Crystal structure of the active form of the proteolytic complex clpP1 and clpP2 | 分子名称: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, BEZ-LEU-LEU | 著者 | LI, M, Wlodawer, A, Maurizi, M. | 登録日 | 2015-09-25 | 公開日 | 2016-02-17 | 最終更新日 | 2016-04-13 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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6VGK
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![BU of 6vgk by Molmil](/molmil-images/mine/6vgk) | ClpP1P2 complex from M. tuberculosis | 分子名称: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2 | 著者 | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | 登録日 | 2020-01-08 | 公開日 | 2020-03-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VGN
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![BU of 6vgn by Molmil](/molmil-images/mine/6vgn) | ClpP1P2 complex from M. tuberculosis bound to ADEP | 分子名称: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, R0M-WFP-ALO-PRO-YCP-ALA-MP8 | 著者 | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | 登録日 | 2020-01-08 | 公開日 | 2020-03-18 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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4U0G
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![BU of 4u0g by Molmil](/molmil-images/mine/4u0g) | Crystal Structure of M. tuberculosis ClpP1P2 bound to ADEP and agonist | 分子名称: | ADEP-2B5Me, ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, ... | 著者 | Schmitz, K.R, Carney, D.W, Sello, J.K, Sauer, R.T. | 登録日 | 2014-07-11 | 公開日 | 2014-10-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.1978 Å) | 主引用文献 | Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc.Natl.Acad.Sci.USA, 111, 2014
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7X8X
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![BU of 7x8x by Molmil](/molmil-images/mine/7x8x) | structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease | 分子名称: | 4-[1-[3-[4-[(4-fluoranyl-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-quinazolin-7-yl]oxypropyl]piperidin-4-yl]benzamide, 4-[[3,5-bis(fluoranyl)phenyl]methyl]-N-[(4-bromophenyl)methyl]piperazine-1-carboxamide, ATP-dependent Clp protease proteolytic subunit 1, ... | 著者 | Bao, R, Luo, Y.F, Zhu, Y.B, Yang, Y, Zhou, Y.Z. | 登録日 | 2022-03-15 | 公開日 | 2023-04-12 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors J.Med.Chem., 66, 2023
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6VGQ
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![BU of 6vgq by Molmil](/molmil-images/mine/6vgq) | ClpP1P2 complex from M. tuberculosis with GLF-CMK bound to ClpP1 | 分子名称: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, Z-Gly-leu-phe-CH2Cl | 著者 | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | 登録日 | 2020-01-08 | 公開日 | 2020-03-18 | 最終更新日 | 2020-04-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR. Proc.Natl.Acad.Sci.USA, 117, 2020
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