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PDB: 43 件
2XCX
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BU of 2xcx by Molmil
Crystal structure of the apoform of the D52N variant of cytosolic 5'- nucleotidase II
分子名称: CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL
著者Wallden, K, Nordlund, P.
登録日2010-04-26
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
6FIS
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BU of 6fis by Molmil
Human cytosolic 5'-nucleotidase II soaked with 10mM 7-Benzyloxymethyl-7H-adenine
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION, ...
著者Aghajari, N, Preeti, P.
登録日2018-01-19
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Eur J Med Chem, 168, 2019
6FXH
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BU of 6fxh by Molmil
Human cytosolic 5'-nucleotidase II soaked with 10mM 3-Phenyl-N-(9H-purin-6-yl)benzamide
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION, ...
著者Aghajari, N, Preeti, P.
登録日2018-03-09
公開日2019-03-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Eur J Med Chem, 168, 2019
2XJB
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BU of 2xjb by Molmil
Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with deoxyguanosine monophosphate and deoxyadenosine triphosphate
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, ...
著者Wallden, K, Nordlund, P.
登録日2010-07-03
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
2XCV
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BU of 2xcv by Molmil
Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inosine monophosphate and 2,3-bisphosphoglycerate
分子名称: (2R)-2,3-diphosphoglyceric acid, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ...
著者Wallden, K, Nordlund, P.
登録日2010-04-26
公開日2011-03-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5'-Nucleotidase II
J.Mol.Biol., 408, 2011
6DDQ
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BU of 6ddq by Molmil
Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the basal state
分子名称: 1,2-ETHANEDIOL, Cytosolic purine 5'-nucleotidase, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DDH
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BU of 6ddh by Molmil
Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target
分子名称: Cytosolic purine 5'-nucleotidase, INOSINIC ACID
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DDO
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BU of 6ddo by Molmil
Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state
分子名称: Cytosolic purine 5'-nucleotidase, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DDK
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BU of 6ddk by Molmil
Crystal structure of the double mutant (D52N/R367Q) of the full-length NT5C2 in the basal state
分子名称: Cytosolic purine 5'-nucleotidase, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6FIR
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BU of 6fir by Molmil
Human cytosolic 5'-nucleotidase II soaked with 5mM3-Phenyl-N-(9H-purin-6-yl)benzamide
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION, ...
著者Aghajari, N, Preeti, P.
登録日2018-01-19
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Eur J Med Chem, 168, 2019
6FIU
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BU of 6fiu by Molmil
Human cytosolic 5'-nucleotidase II soaked with 10mM 2-(6-([1,1'-Biphenyl]-3-carboxamido)-9H-purin-9-yl)acetic acid
分子名称: Cytosolic purine 5'-nucleotidase, GLYCEROL, MAGNESIUM ION, ...
著者Aghajari, N, Preeti, P.
登録日2018-01-19
公開日2019-01-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Lead optimization and biological evaluation of fragment-based cN-II inhibitors.
Eur J Med Chem, 168, 2019
6DDB
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BU of 6ddb by Molmil
Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target
分子名称: Cytosolic purine 5'-nucleotidase, MANGANESE (II) ION, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2018-05-09
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
5CQZ
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BU of 5cqz by Molmil
Human cytosolic 5'-nucleotidase II in complex with 3-(3-Imidazol-1-ylphenyl)-N-(9H-purin-6-yl)benzamide
分子名称: 1-(biphenyl-3-yl)-1H-imidazole, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
著者Preeti, P, Aghajari, N.
登録日2015-07-22
公開日2015-12-23
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
J.Med.Chem., 58, 2015
5CR7
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BU of 5cr7 by Molmil
Human cytosolic 5'-nucleotidase II in complex with N-(9H-Purin-6-yl)-3-(3-pyrrol-1-ylphenyl)benzamide
分子名称: ACETATE ION, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
著者Aghajari, N, Preeti, P.
登録日2015-07-22
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach.
J.Med.Chem., 58, 2015
4H4B
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BU of 4h4b by Molmil
Human cytosolic 5'-nucleotidase II in complex with Anthraquinone-2,6- disulfonic acid
分子名称: 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid, Cytosolic purine 5'-nucleotidase, GLYCEROL, ...
著者Rhimi, M, Aghajari, N.
登録日2012-09-17
公開日2012-12-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Identification and characterization of inhibitors of cytoplasmic 5'-nucleotidase cN-II issued from virtual screening.
Biochem Pharmacol, 85, 2013
6DDX
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BU of 6ddx by Molmil
Crystal structure of the double mutant (D52N/L375F) of NT5C2-537X in the active state, Northeast Structural Genomics Target
分子名称: Cytosolic purine 5'-nucleotidase, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2018-05-10
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.901 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DDC
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BU of 6ddc by Molmil
Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target
分子名称: Cytosolic purine 5'-nucleotidase, MAGNESIUM ION, PHOSPHATE ION
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L, Northeast Structural Genomics Consortium (NESG)
登録日2018-05-09
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
6DE3
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BU of 6de3 by Molmil
Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the active state
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cytosolic purine 5'-nucleotidase, MAGNESIUM ION, ...
著者Forouhar, F, Dieck, C.L, Tzoneva, G, Carpenter, Z, Ambesi-Impiombato, A, Sanchez-Martin, M, Kirschner-Schwabe, R, Lew, S, Seetharaman, J, Ferrando, A.A, Tong, L.
登録日2018-05-11
公開日2018-07-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.
Cancer Cell, 34, 2018
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