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PDB: 187 件
6UQ1
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BU of 6uq1 by Molmil
RNA polymerase II elongation complex with 5-guanidinohydantoin lesion in state 6
分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者Oh, J, Wang, D.
登録日2019-10-18
公開日2020-06-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.
Proc.Natl.Acad.Sci.USA, 117, 2020
8UKU
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BU of 8uku by Molmil
RNA polymerase II elongation complex with Fapy-dG lesion with CMP added
分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者Hou, P, Oh, J, Wang, D.
登録日2023-10-15
公開日2024-04-24
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
8UKT
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BU of 8ukt by Molmil
RNA polymerase II elongation complex with Fapy-dG lesion with AMP added
分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者Hou, P, Oh, J, Wang, D.
登録日2023-10-15
公開日2024-04-24
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
5W4U
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BU of 5w4u by Molmil
Pol II elongation complex with an N6-methyladenine-containing template
分子名称: 14mer non-template DNA, 29mer template DNA, 9mer RNA, ...
著者Wang, W, Wang, D.
登録日2017-06-13
公開日2018-06-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Epigenetic DNA Modification N6-Methyladenine Causes Site-Specific RNA Polymerase II Transcriptional Pausing.
J.Am.Chem.Soc., 139, 2017
4BY1
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BU of 4by1 by Molmil
elongating RNA Polymerase II-Bye1 TLD complex soaked with AMPCPP
分子名称: 5'-D(*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP)-3', 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP *TP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*AP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', ...
著者Kinkelin, K, Wozniak, G.G, Rothbart, S.B, Lidschreiber, M, Strahl, B.D, Cramer, P.
登録日2013-07-17
公開日2013-09-11
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structures of RNA Polymerase II Complexes with Bye1, a Chromatin-Binding Phf3/Dido1 Homologue
Proc.Natl.Acad.Sci.USA, 110, 2013
2NVX
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BU of 2nvx by Molmil
RNA polymerase II elongation complex in 5 mM Mg+2 with 2'-dUTP
分子名称: 28-MER DNA template strand, 5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3', 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3', ...
著者Wang, D, Bushnell, D.A, Westover, K.D, Kaplan, C.D, Kornberg, R.D.
登録日2006-11-13
公開日2006-12-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
Cell(Cambridge,Mass.), 127, 2006
7KED
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BU of 7ked by Molmil
RNA polymerase II elongation complex with unnatural base dTPT3
分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者Oh, J, Wang, W, Wang, D.
登録日2020-10-10
公開日2021-06-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.
Nat.Chem.Biol., 17, 2021
4BBS
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BU of 4bbs by Molmil
Structure of an initially transcribing RNA polymerase II-TFIIB complex
分子名称: 5'-D(*AP*GP*CP*GP*CP*AP*GP*TP*TP*GP*TP*GP*CP*TP *AP*TP*GP*AP*TP*AP*TP*TP*TP*TP*TP*AP*TP)-3', 5'-D(*GP*GP*CP*AP*CP*AP*AP*CP*TP*GP*CP*GP*CP*TP)-3', 5'-R(*AP*UP*AP*UP*CP*AP)-3', ...
著者Sainsbury, S, Niesser, J, Cramer, P.
登録日2012-09-27
公開日2012-11-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structure and Function of the Initially Transcribing RNA Polymerase II-TFIIB Complex
Nature, 493, 2013
1SFO
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BU of 1sfo by Molmil
RNA POLYMERASE II STRAND SEPARATED ELONGATION COMPLEX
分子名称: DNA STRAND, DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 14.2 kDa polypeptide, ...
著者Westover, K.D, Bushnell, D.A, Kornberg, R.D.
登録日2004-02-20
公開日2004-03-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.61 Å)
主引用文献Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
Science, 303, 2004
3HOX
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BU of 3hox by Molmil
Complete RNA polymerase II elongation complex V
分子名称: 5'-D(*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*C*AP*AP*GP*TP*AP*GP*TP*TP*AP*AP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*U*CP*AP*AP*CP*CP*AP*GP*GP*CP*UP*U)-3', ...
著者Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P.
登録日2009-06-03
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
Mol.Cell, 34, 2009
3HOZ
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BU of 3hoz by Molmil
Complete RNA polymerase II elongation complex IV with a T-U mismatch and a frayed RNA 3'-guanine
分子名称: 5'-D(*AP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*C*AP*AP*GP*TP*AP*GP*TP*TP*CP*TP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*U*CP*AP*AP*CP*CP*AP*GP*GP*CP*UP*G)-3', ...
著者Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P.
登録日2009-06-03
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
Mol.Cell, 34, 2009
3I4M
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BU of 3i4m by Molmil
8-oxoguanine containing RNA polymerase II elongation complex D
分子名称: DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
著者Damsma, G.E, Cramer, P.
登録日2009-07-02
公開日2009-09-08
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Molecular basis of transcriptional mutagenesis at 8-oxoguanine
J.Biol.Chem., 284, 2009
8TVP
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BU of 8tvp by Molmil
Cryo-EM structure of CPD-stalled Pol II in complex with Rad26 (open state)
分子名称: DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ...
著者Sarsam, R.D, Lahiri, I, Leschziner, A.E.
登録日2023-08-18
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TVV
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BU of 8tvv by Molmil
Cryo-EM structure of backtracked Pol II
分子名称: DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ...
著者Sarsam, R.D, Lahiri, I, Leschziner, A.E.
登録日2023-08-18
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
8TVX
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BU of 8tvx by Molmil
Cryo-EM structure of CPD-stalled Pol II (Conformation 2)
分子名称: DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ...
著者Sarsam, R.D, Lahiri, I, Leschziner, A.E.
登録日2023-08-18
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Proc.Natl.Acad.Sci.USA, 121, 2024
5C3E
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BU of 5c3e by Molmil
Crystal structure of a transcribing RNA Polymerase II complex reveals a complete transcription bubble
分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者Barnes, C.O, Calero, M, Malik, I, Spahr, H, Zhang, Q, Pullara, F, Kaplan, C.D, Calero, G.
登録日2015-06-17
公開日2015-08-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Mol.Cell, 59, 2015
7RIY
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BU of 7riy by Molmil
RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 2 soaked with UTP
分子名称: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
著者Oh, J, Dervan, P.B, Wang, D.
登録日2021-07-20
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.
Proc.Natl.Acad.Sci.USA, 119, 2022
4A3J
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BU of 4a3j by Molmil
RNA Polymerase II initial transcribing complex with a 2nt DNA-RNA hybrid and soaked with GMPCPP
分子名称: 5'-D(*AP*GP*CP*TP*AP*GP*CP*TP*TP*TP*CP*BRUP*AP*CP*CP *TP*GP*AP*AP*CP*AP*AP*CP*TP*AP*AP*CP)-3', 5'-D(*GP*TP*AP*GP*AP*AP*AP*GP*CP*TP*AP*GP*CP*TP)-3', 5'-R(*CP*AP)-3', ...
著者Cheung, A.C.M, Sainsbury, S, Cramer, P.
登録日2011-09-30
公開日2011-12-07
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Structural Basis of Initial RNA Polymerase II Transcription.
Embo J., 30, 2011
3GTG
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BU of 3gtg by Molmil
Backtracked RNA polymerase II complex with 12mer RNA
分子名称: DNA (28-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ...
著者Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
登録日2009-03-27
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.78 Å)
主引用文献Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
8UKR
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BU of 8ukr by Molmil
RNA polymerase II elongation complex with Fapy-dG lesion soaking with ATP before chemistry
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
著者Hou, P, Oh, J, Wang, D.
登録日2023-10-15
公開日2024-04-24
実験手法X-RAY DIFFRACTION (3.78 Å)
主引用文献Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG.
J.Am.Chem.Soc., 146, 2024
1WCM
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BU of 1wcm by Molmil
Complete 12-Subunit RNA Polymerase II at 3.8 Angstrom
分子名称: DNA-DIRECTED RNA POLYMERASE II 13.6 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 14.2 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II 19 KD POLYPEPTIDE, ...
著者Armache, K.-J, Mitterweger, S, Meinhart, A, Cramer, P.
登録日2004-11-17
公開日2004-12-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structures of Complete RNA Polymerase II and its Subcomplex,Rpb4/7
J.Biol.Chem., 280, 2005
3GTQ
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BU of 3gtq by Molmil
Backtracked RNA polymerase II complex induced by damage
分子名称: DNA (5'-D(*CP*TP*AP*CP*CP*CP*AP*TP*AP*AP*CP*CP*AP*CP*AP*GP*GP*CP*TP*CP*CP*TP*CP*TP*CP*CP*AP*TP*C)-3'), DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ...
著者Wang, D, Bushnell, D.A, Huang, X, Westover, K.D, Levitt, M, Kornberg, R.D.
登録日2009-03-27
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural basis of transcription: backtracked RNA polymerase II at 3.4 angstrom resolution.
Science, 324, 2009
2JA8
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BU of 2ja8 by Molmil
CPD lesion containing RNA Polymerase II elongation complex D
分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TP*TP*TP*TTP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*AP*UP)-3', ...
著者Brueckner, F, Hennecke, U, Carell, T, Cramer, P.
登録日2006-11-23
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Cpd Damage Recognition by Transcribing RNA Polymerase II.
Science, 315, 2007
2JA7
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BU of 2ja7 by Molmil
CPD lesion containing RNA Polymerase II elongation complex C
分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TP*TP*TTP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', ...
著者Brueckner, F, Hennecke, U, Carell, T, Cramer, P.
登録日2006-11-23
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Cpd Damage Recognition by Transcribing RNA Polymerase II.
Science, 315, 2007
2JA5
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CPD lesion containing RNA Polymerase II elongation complex A
分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TTP*TP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', DNA-directed RNA polymerase II subunit RPB1, ...
著者Brueckner, F, Hennecke, U, Carell, T, Cramer, P.
登録日2006-11-23
公開日2007-02-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Cpd Damage Recognition by Transcribing RNA Polymerase II
Science, 315, 2007

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