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PDB: 57 件
4O0A
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Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
分子名称: 5-{4-[({[4-(5-carboxyfuran-2-yl)-2-chlorophenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Kennedy, J.P, Waterson, A.G, Olejniczak, E.T, Pelz, N.F, Patrone, J.D, Vangamudi, B, Camper, D.V, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2013-12-13
公開日2014-01-08
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.
J. Med. Chem., 56, 2013
5E7N
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Crystal Structure of RPA70N in complex with VU0085636
分子名称: 2-({3-[(4-bromophenyl)sulfamoyl]-4-methylbenzoyl}amino)benzoic acid, Replication protein A 70 kDa DNA-binding subunit
著者Gilston, B.A, Patrone, J.D, Pelz, N.F, Bates, B.S, Souza-Fagundes, E.M, Vangamudi, B, Camper, D, Kuznetsov, A, Browning, C.F, Feldkamp, M.D, Olejniczak, E.T, Rossanese, O.W, Waterson, A.G, Fesik, S.W, Chazin, W.J.
登録日2015-10-12
公開日2016-01-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A.
Chemmedchem, 11, 2016
4IPC
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Structure of the N-terminal domain of RPA70, E7R mutant
分子名称: Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Vangamudi, B, Fesik, S.W, Chazin, W.J.
登録日2013-01-09
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting Protein.
Biochemistry, 52, 2013
4R4T
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Crystal Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)phenylthioamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-{4-[({[4-(5-carboxyfuran-2-yl)phenyl]carbonothioyl}amino)methyl]phenyl}-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
5N8A
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Structure of RPA70N in complex with PrimPol (fragment 480-560)
分子名称: DNA-directed primase/polymerase protein, Replication protein A 70 kDa DNA-binding subunit
著者Brissett, N.C, Doherty, A.J.
登録日2017-02-23
公開日2017-06-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Molecular basis for PrimPol recruitment to replication forks by RPA.
Nat Commun, 8, 2017
4R4O
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Crystal structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)benzyl)carbamothioyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-(4-{[4-(5-carboxyfuran-2-yl)benzyl]carbamothioyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4Q
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Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-[4-({acetyl[4-(5-carboxyfuran-2-yl)benzyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4NB3
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Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide
分子名称: 3,4 dichlorophenylalanine ATRIP derived peptide, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Vangamudi, B, Souza-Fagundes, E.M, Luzwik, J.W, Cortez, D, Olejniczak, O.T, Waterson, A.G, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2013-10-22
公開日2014-02-26
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.
J.Med.Chem., 57, 2014
8K00
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RPA70N-MRE11 fusion
分子名称: Double-strand break repair protein MRE11, Replication protein A 70 kDa DNA-binding subunit
著者Fu, W.M, Wu, Y.Y, Zhou, C.
登録日2023-07-07
公開日2023-09-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural characterization of human RPA70N association with DNA damage response proteins.
Elife, 12, 2023
4R4I
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Structure of RPA70N in complex with 5-(4-((6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-(4-{[6-(5-carboxyfuran-2-yl)-1-thioxo-3,4-dihydroisoquinolin-2(1H)-yl]methyl}phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4R4C
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Structure of RPA70N in complex with 5-(4-((4-(5-carboxyfuran-2-yl)-2-chlorobenzamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
分子名称: 5-[4-({[4-(5-carboxyfuran-2-yl)-2-chlorobenzoyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Waterson, A.G, Kennedy, J.P, Patrone, J.D, Pelz, N.F, Frank, A.O, Vangamudi, B, Sousa-Fagundes, E.M, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2014-08-19
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6, 2015
4LUV
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BU of 4luv by Molmil
Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
分子名称: 1-(3-methylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, 5-(3-chloro-4-fluorophenyl)furan-2-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Kennedy, J.P, Waterson, A.G, Olejnczak, E.O, Pelz, N.F, Patrone, J.D, Vangamudi, B, Camper, D.V, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2013-07-25
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.
J.Med.Chem., 56, 2013
4IJH
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BU of 4ijh by Molmil
Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A
分子名称: 3-chloro-6-[3-(4-fluorophenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]-1-benzothiophene-2-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Patrone, J.D, Kennedy, J.P, Frank, A.O, Vangamudi, B, Pelz, N.F, Rossanese, O.W, Waterson, A.G, Fesik, S.W, Chazin, W.J.
登録日2012-12-21
公開日2013-08-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.498 Å)
主引用文献Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.
ACS MED.CHEM.LETT., 4, 2013
8JZV
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RPA70N-ETAA1 fusion
分子名称: Ewing's tumor-associated antigen 1, Replication protein A 70 kDa DNA-binding subunit
著者Fu, W.M, Wu, Y.Y, Zhou, C.
登録日2023-07-06
公開日2023-09-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural characterization of human RPA70N association with DNA damage response proteins.
Elife, 12, 2023
8JZY
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RPA70N-RAD9 fusion
分子名称: Cell cycle checkpoint control protein RAD9A, Replication protein A 70 kDa DNA-binding subunit
著者Fu, W.M, Wu, Y.Y, Zhou, C.
登録日2023-07-06
公開日2023-09-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural characterization of human RPA70N association with DNA damage response proteins.
Elife, 12, 2023
7XV0
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BU of 7xv0 by Molmil
Crystal structure of RPA70N-BLMp1 fusion
分子名称: Bloom syndrome protein, Replication protein A 70 kDa DNA-binding subunit
著者Wu, Y.Y, Zang, N, Fu, W.M, Zhou, C.
登録日2022-05-20
公開日2023-06-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural characterization of human RPA70N association with DNA damage response proteins.
Elife, 12, 2023
4IPD
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Structure of the N-terminal domain of RPA70, E100R mutant
分子名称: Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Vangamudi, B, Fesik, S.W, Chazin, W.J.
登録日2013-01-09
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting Protein.
Biochemistry, 52, 2013
4LUO
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Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
分子名称: 1-(3-methylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid, Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Kennedy, J.P, Waterson, A.G, Olejniczak, E.T, Pelz, N.F, Patrone, J.D, Vangamudi, B, Camper, D.V, Rossanese, O.W, Fesik, S.W, Chazin, W.J.
登録日2013-07-25
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach.
J.Med.Chem., 56, 2013
7GQU
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Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide
分子名称: ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ...
著者Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G.
登録日2023-10-19
公開日2024-05-01
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
5EAY
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Crystal structure of a Dna2 peptide in complex with Rpa 70N
分子名称: DNA replication ATP-dependent helicase/nuclease DNA2, Replication protein A 70 kDa DNA-binding subunit
著者Zhou, C, Pourmal, S, Pavletich, N.P.
登録日2015-10-17
公開日2015-11-18
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
Elife, 4, 2015
7GQS
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Crystal Structure of Werner helicase fragment 517-945 in complex with ADP
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ...
著者Classen, M, Benz, J, Brugger, D, Rudolph, M.G.
登録日2023-10-19
公開日2024-05-01
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
Nature, 629, 2024
4IPG
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BU of 4ipg by Molmil
Structure of the N-terminal domain of RPA70, E7R, E100R mutant
分子名称: Replication protein A 70 kDa DNA-binding subunit
著者Feldkamp, M.D, Frank, A.O, Vangamudi, B, Fesik, S.W, Chazin, W.J.
登録日2013-01-09
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting Protein.
Biochemistry, 52, 2013
8PFP
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Crystal structure of WRN helicase domain in complex with ATPgammaS
分子名称: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ZINC ION
著者Scheufler, C, Villard, F.
登録日2023-06-16
公開日2024-04-24
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Nature, 629, 2024
2B3G
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p53N (fragment 33-60) bound to RPA70N
分子名称: Cellular tumor antigen p53, Replication protein A 70 kDa DNA-binding subunit
著者Bochkareva, E, Kaustov, L, Ayed, A, Yi, G.S, Lu, Y, Pineda-Lucena, A, Liao, J.C, Okorokov, A.L, Milner, J, Arrowsmith, C.H, Bochkarev, A.
登録日2005-09-20
公開日2005-10-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A.
Proc.Natl.Acad.Sci.Usa, 102, 2005
7XV4
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Crystal structure of RPA70N-ATRIP fusion
分子名称: ATR-interacting protein, Replication protein A 70 kDa DNA-binding subunit
著者Wu, Y.Y, Zang, N, Fu, W.M, Zhou, C.
登録日2022-05-20
公開日2023-06-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural characterization of human RPA70N association with DNA damage response proteins.
Elife, 12, 2023

 

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