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PDB: 29 件
2D48
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Crystal structure of the Interleukin-4 variant T13D
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-11
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8X
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BU of 2b8x by Molmil
Crystal structure of the interleukin-4 variant F82D
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8U
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BU of 2b8u by Molmil
Crystal structure of wildtype human Interleukin-4
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B8Y
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BU of 2b8y by Molmil
Crystal structure of the interleukin-4 variant T13DF82D
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
2B91
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Crystal structure of the interleukin-4 variant F82DR85A
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
4YDY
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BU of 4ydy by Molmil
CRYSTAL STRUCTURE OF DARPIN 44C12V5 IN COMPLEX WITH HUMAN IL-4
分子名称: ACETATE ION, DARPIN 44C12V5, GLYCEROL, ...
著者Teplyakov, A, Obmolova, G, Gilliland, G.
登録日2015-02-23
公開日2015-03-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献CRYSTAL STRUCTURE OF DARPIN 44C12V5 IN COMPLEX WITH HUMAN IL-4
To Be Published
1HZI
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BU of 1hzi by Molmil
INTERLEUKIN-4 MUTANT E9A
分子名称: INTERLEUKIN-4, SULFATE ION
著者Hulsmeyer, M, Scheufler, C, Dreyer, M.K.
登録日2001-01-25
公開日2001-08-29
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.
Acta Crystallogr.,Sect.D, 57, 2001
2B90
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BU of 2b90 by Molmil
Crystal structure of the interleukin-4 variant T13DR85A
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
1RCB
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BU of 1rcb by Molmil
CRYSTAL STRUCTURE OF HUMAN RECOMBINANT INTERLEUKIN-4 AT 2.25 ANGSTROMS RESOLUTION
分子名称: INTERLEUKIN-4
著者Wlodawer, A, Pavlovsky, A, Gustchina, A.
登録日1992-08-26
公開日1993-10-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of human recombinant interleukin-4 at 2.25 A resolution.
FEBS Lett., 309, 1992
1IAR
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BU of 1iar by Molmil
INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
分子名称: PROTEIN (INTERLEUKIN-4 RECEPTOR ALPHA CHAIN), PROTEIN (INTERLEUKIN-4)
著者Hage, T, Sebald, W, Reinemer, P.
登録日1999-02-25
公開日2000-03-03
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.
Cell(Cambridge,Mass.), 97, 1999
2INT
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BU of 2int by Molmil
CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4
分子名称: INTERLEUKIN-4
著者Walter, M.R, Cook, W.J, Zhao, B.G, Cameron Junior, R, Ealick, S.E, Walter Junior, R.L, Reichert, P, Nagabhushan, T.L, Trotta, P.P, Bugg, C.E.
登録日1993-07-22
公開日1994-01-31
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of recombinant human interleukin-4.
J.Biol.Chem., 267, 1992
2B8Z
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Crystal structure of the interleukin-4 variant R85A
分子名称: Interleukin-4, SULFATE ION
著者Kraich, M, Klein, M, Patino, E, Harrer, H, Sebald, W, Mueller, T.D.
登録日2005-10-10
公開日2006-05-30
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
Bmc Biol., 4, 2006
5FHX
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BU of 5fhx by Molmil
CRYSTAL STRUCTURE OF CODV IN COMPLEX WITH IL4 AT 2.55 Ang. RESOLUTION.
分子名称: Antibody fragment light chain, Interleukin-4, PHOSPHATE ION, ...
著者Vallee, F, Dupuy, A, Rak, A.
登録日2015-12-22
公開日2016-03-30
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.
Mabs, 8, 2016
1HIK
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INTERLEUKIN-4 (WILD-TYPE)
分子名称: INTERLEUKIN-4
著者Mueller, T, Buehner, M.
登録日1995-06-01
公開日1996-01-29
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
3BPL
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BU of 3bpl by Molmil
Crystal structure of the IL4-IL4R-Common Gamma ternary complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Garcia, K.C.
登録日2007-12-18
公開日2008-02-05
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
1HIJ
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BU of 1hij by Molmil
INTERLEUKIN-4 MUTANT WITH ARG 88 REPLACED WITH GLN (R88Q)
分子名称: INTERLEUKIN-4
著者Mueller, T, Buehner, M.
登録日1995-06-01
公開日1996-01-29
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
3BPN
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BU of 3bpn by Molmil
Crystal structure of the IL4-IL4R-IL13Ra ternary complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13 receptor alpha-1 chain, Interleukin-4, ...
著者Garcia, K.C.
登録日2007-12-18
公開日2008-02-05
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System.
Cell(Cambridge,Mass.), 132, 2008
6OEL
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BU of 6oel by Molmil
Engineered Fab bound to IL-4 receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ...
著者Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C.
登録日2019-03-27
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A strategy for the selection of monovalent antibodies that span protein dimer interfaces.
J.Biol.Chem., 294, 2019
3QB7
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BU of 3qb7 by Molmil
Interleukin-4 mutant RGA bound to cytokine receptor common gamma
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ...
著者Bates, D.L, Junttila, I.S, Creusot, R.J, Moraga, I, Lupardus, P, Fathman, C.G, Paul, W.E, Garcia, K.C.
登録日2011-01-12
公開日2012-04-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.245 Å)
主引用文献Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.
Nat.Chem.Biol., 8, 2012
1ITL
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BU of 1itl by Molmil
HUMAN INTERLEUKIN 4: THE SOLUTION STRUCTURE OF A FOUR-HELIX-BUNDLE PROTEIN
分子名称: INTERLEUKIN-4
著者Smith, L.J, Redfield, C, Boyd, J, Lawrence, G.M.P, Edwards, R.G, Smith, R.A.G, Dobson, C.M.
登録日1992-02-08
公開日1993-04-15
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Human interleukin 4. The solution structure of a four-helix bundle protein.
J.Mol.Biol., 224, 1992
1BCN
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BU of 1bcn by Molmil
THREE-DIMENSIONAL SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-4 BY MULTI-DIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
分子名称: INTERLEUKIN-4
著者Clore, G.M, Powers, B, Garrett, D.S, Gronenborn, A.M.
登録日1992-05-01
公開日1993-10-31
最終更新日2024-06-05
実験手法SOLUTION NMR
主引用文献Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.
Science, 256, 1992
1BBN
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BU of 1bbn by Molmil
THREE-DIMENSIONAL SOLUTION STRUCTURE OF HUMAN INTERLEUKIN-4 BY MULTI-DIMENSIONAL HETERONUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
分子名称: INTERLEUKIN-4
著者Clore, G.M, Powers, B, Garrett, D.S, Gronenborn, A.M.
登録日1992-05-01
公開日1993-10-31
最終更新日2024-06-05
実験手法SOLUTION NMR
主引用文献Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.
Science, 256, 1992
8CH7
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BU of 8ch7 by Molmil
RDC-refined Interleukin-4 (wild type) pH 5.6
分子名称: Interleukin-4
著者Vaz, D.C, Rodrigues, J.R, Loureiro-Ferreira, N, Mueller, T, Sebald, W, Redfield, C, Brito, R.M.M.
登録日2023-02-07
公開日2023-10-18
最終更新日2024-01-17
実験手法SOLUTION NMR
主引用文献Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
8CGF
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Interleukin-4 (wild type) pH 2.4
分子名称: Interleukin-4
著者Vaz, D.C, Rodrigues, J.R, Loureiro-Ferreira, N, Mueller, T, Sebald, W, Redfield, C, Brito, R.M.M.
登録日2023-02-04
公開日2023-10-18
最終更新日2024-01-17
実験手法SOLUTION NMR
主引用文献Lessons on protein structure from interleukin-4: All disulfides are not created equal.
Proteins, 92, 2024
1CYL
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BU of 1cyl by Molmil
ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
分子名称: INTERLEUKIN-4
著者Mueller, T, Sebald, W, Oschkinat, H.
登録日1994-02-21
公開日1994-09-30
最終更新日2022-02-16
実験手法SOLUTION NMR
主引用文献Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy.
J.Mol.Biol., 237, 1994

 

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