1EB2
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![BU of 1eb2 by Molmil](/molmil-images/mine/1eb2) | Trypsin inhibitor complex (BPO) | 分子名称: | 3-[(Z)-AMINO(IMINO)METHYL]-N-[2-(4-BENZOYL-1-PIPERIDINYL)-2-OXO-1-PHENYLETHYL]BENZAMIDE, CALCIUM ION, SULFATE ION, ... | 著者 | Wilkinson, K.W, Young, S.C, Liebeschuetz, J.W, Brady, R.L. | 登録日 | 2001-07-18 | 公開日 | 2002-02-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Pro_Select: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa Inhibitors J.Med.Chem., 45, 2002
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1V2K
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![BU of 1v2k by Molmil](/molmil-images/mine/1v2k) | Factor XA specific Inhibitor in complex with bovine trypsin variant X(triple.Glu)bT.D2 | 分子名称: | CALCIUM ION, SULFATE ION, Trypsin, ... | 著者 | Rauh, D, Klebe, G, Stubbs, M.T. | 登録日 | 2003-10-17 | 公開日 | 2004-06-01 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Understanding protein-ligand interactions: the price of protein flexibility J.Mol.Biol., 335, 2004
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1O3A
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![BU of 1o3a by Molmil](/molmil-images/mine/1o3a) | Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors | 分子名称: | 3-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-1,1'-BIPHENYL-2-OLATE, BETA-TRYPSIN, CALCIUM ION | 著者 | Katz, B.A, Elrod, K, Verner, E, Mackman, R.L, Luong, C, Shrader, W.D, Sendzik, M, Spencer, J.R, Sprengeler, P.A, Kolesnikov, A, Tai, V.W, Hui, H.C, Breitenbucher, J.G, Allen, D, Janc, J.W. | 登録日 | 2003-03-06 | 公開日 | 2003-09-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease
inhibitors. J.Mol.Biol., 329, 2003
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1PPE
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1OX1
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![BU of 1ox1 by Molmil](/molmil-images/mine/1ox1) | crystal structure of the bovine trypsin complex with a synthetic 11 peptide inhibitor | 分子名称: | 11-mer peptide, CALCIUM ION, Trypsinogen, ... | 著者 | Wu, G, Huang, Y, Zhu, G, Huang, Q, Tang, Y, Miyake, H, Kusunoki, M. | 登録日 | 2003-03-31 | 公開日 | 2004-05-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | crystal structure of the bovine trypsin complex with a synthetic 11 peptide inhibitor To be published
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1K1N
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![BU of 1k1n by Molmil](/molmil-images/mine/1k1n) | BOVINE TRYPSIN-INHIBITOR COMPLEX | 分子名称: | CALCIUM ION, TRYPSIN, [N-[N-(4-METHOXY-2,3,6-TRIMETHYLPHENYLSULFONYL)-L-ASPARTYL]-D-(4-AMIDINO-PHENYLALANYL)]-PIPERIDINE | 著者 | Stubbs, M.T. | 登録日 | 2001-09-25 | 公開日 | 2001-11-28 | 最終更新日 | 2012-12-12 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition. J.Mol.Biol., 313, 2001
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1K1O
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![BU of 1k1o by Molmil](/molmil-images/mine/1k1o) | BOVINE TRYPSIN-INHIBITOR COMPLEX | 分子名称: | CALCIUM ION, TRYPSIN, {[(1R)-2-((2S)-2-{[(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)AMINO]CARBONYL}PIPERIDINYL)-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]AMINO}ACETIC ACID | 著者 | Stubbs, M.T. | 登録日 | 2001-09-25 | 公開日 | 2001-11-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition. J.Mol.Biol., 313, 2001
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1JIR
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![BU of 1jir by Molmil](/molmil-images/mine/1jir) | Crystal Structure of Trypsin Complex with Amylamine in Cyclohexane | 分子名称: | AMYLAMINE, CALCIUM ION, SULFATE ION, ... | 著者 | Wu, G, Zhu, G, Huang, Q, Qian, M, Tang, Y. | 登録日 | 2001-07-02 | 公開日 | 2001-07-18 | 最終更新日 | 2017-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of beta-Trypsin Complex with Amylamine in Cyclohexane To be Published
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2D8W
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![BU of 2d8w by Molmil](/molmil-images/mine/2d8w) | Structure of HYPER-VIL-trypsin | 分子名称: | CALCIUM ION, Cationic trypsin, IODIDE ION | 著者 | Miyatake, H, Hasegawa, T, Yamano, A. | 登録日 | 2005-12-08 | 公開日 | 2006-07-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | New methods to prepare iodinated derivatives by vaporizing iodine labelling (VIL) and hydrogen peroxide VIL (HYPER-VIL) ACTA CRYSTALLOGR.,SECT.D, 62, 2006
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6B6T
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![BU of 6b6t by Molmil](/molmil-images/mine/6b6t) | |
6B6R
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6B6P
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6B6Q
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![BU of 6b6q by Molmil](/molmil-images/mine/6b6q) | |
6B6S
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3BTW
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![BU of 3btw by Molmil](/molmil-images/mine/3btw) | THE CRYSTAL STRUCTURES OF THE COMPLEXES BETWEEN BOVINE BETA-TRYPSIN AND TEN P1 VARIANTS OF BPTI | 分子名称: | CALCIUM ION, PROTEIN (BOVINE PANCREATIC TRYPSIN INHIBITOR), PROTEIN (TRYPSIN), ... | 著者 | Helland, R, Otlewski, J, Sundheim, O, Dadlez, M, Smalas, A.O. | 登録日 | 1999-03-11 | 公開日 | 2000-03-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The crystal structures of the complexes between bovine beta-trypsin and ten P1 variants of BPTI. J.Mol.Biol., 287, 1999
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7JR1
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![BU of 7jr1 by Molmil](/molmil-images/mine/7jr1) | Crystal structure of the R64F mutant of Bauhinia Bauhinioides Kallikrein Inhibitor complexed with Bovine Trypsin | 分子名称: | Cationic trypsin, Kunitz-type inihibitor, SODIUM ION, ... | 著者 | Li, M, Wlodawer, A, Gustchina, A. | 登録日 | 2020-08-11 | 公開日 | 2021-07-21 | 最終更新日 | 2021-08-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI. Acta Crystallogr D Struct Biol, 77, 2021
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3QK1
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![BU of 3qk1 by Molmil](/molmil-images/mine/3qk1) | Crystal Structure of Enterokinase-like Trypsin Variant | 分子名称: | 1,2-ETHANEDIOL, BENZAMIDINE, CALCIUM ION, ... | 著者 | Schoepfel, M, Tziridis, A, Arnold, U, Stubbs, M.T. | 登録日 | 2011-01-31 | 公開日 | 2011-03-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Towards a restriction proteinase: construction of a self-activating enzyme. Chembiochem, 12, 2011
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2A7H
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![BU of 2a7h by Molmil](/molmil-images/mine/2a7h) | On the Routine Use of Soft X-Rays in Macromolecular Crystallography, Part III- The Optimal Data Collection Wavelength | 分子名称: | CALCIUM ION, CHLORIDE ION, Cationic trypsin | 著者 | Mueller-Dieckmann, C, Panjikar, S, Tucker, P.A, Weiss, M.S. | 登録日 | 2005-07-05 | 公開日 | 2005-07-19 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | On the routine use of soft X-rays in macromolecular crystallography. Part III. The optimal data-collection wavelength. Acta Crystallogr.,Sect.D, 61, 2005
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7AYS
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1QL7
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1YP9
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![BU of 1yp9 by Molmil](/molmil-images/mine/1yp9) | Trypsin Inhibitor Complex | 分子名称: | (1R,3AS,4R,8AS,8BR)-4-(2-BENZO[1,3]DIOXOL-5-YLMETHYL)-1-BENZYL-3-OXO-DECAHYDRO-PYRROLO[3,4-A]PYRROZILIN-4-YL-BENZAMIDINE, CALCIUM ION, Cationic trypsin, ... | 著者 | Fokkens, J, Obst-Sander, U, Heine, A, Diederich, F, Klebe, G. | 登録日 | 2005-01-31 | 公開日 | 2006-01-17 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A simple protocol to estimate differences in protein binding affinity for enantiomers without prior resolution of racemates Angew.Chem.Int.Ed.Engl., 45, 2006
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3UUZ
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![BU of 3uuz by Molmil](/molmil-images/mine/3uuz) | Bovine trypsin variant X(triplePhe227) in complex with small molecule inhibitor | 分子名称: | CALCIUM ION, Cationic trypsin, GLYCEROL, ... | 著者 | Tziridis, A, Neumann, P, Kolenko, P, Stubbs, M.T. | 登録日 | 2011-11-29 | 公開日 | 2012-12-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues. Biol.Chem., 395, 2014
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1YYY
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![BU of 1yyy by Molmil](/molmil-images/mine/1yyy) | Trypsin inhibitors with rigid tripeptidyl aldehydes | 分子名称: | 2-{(3S)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2S)-1-[(3S)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide, CALCIUM ION, TRYPSIN | 著者 | Krishnan, R, Zhang, E, Hakansson, K, Arni, R.K, Tulinsky, A, Lim-Wilby, M.S.L, Levy, O.E, Semple, J.E, Brunck, T.K. | 登録日 | 1998-06-03 | 公開日 | 1999-06-08 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. Biochemistry, 37, 1998
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2TPI
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![BU of 2tpi by Molmil](/molmil-images/mine/2tpi) | ON THE DISORDERED ACTIVATION DOMAIN IN TRYPSINOGEN. CHEMICAL LABELLING AND LOW-TEMPERATURE CRYSTALLOGRAPHY | 分子名称: | ISOLEUCINE, MERCURY (II) ION, TRYPSIN INHIBITOR, ... | 著者 | Walter, J, Steigemann, W, Singh, T.P, Bartunik, H, Bode, W, Huber, R. | 登録日 | 1981-10-26 | 公開日 | 1982-03-04 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | On the Disordered Activation Domain in Trypsinogen. Chemical Labelling and Low-Temperature Crystallography Acta Crystallogr.,Sect.B, 38, 1982
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1SMF
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![BU of 1smf by Molmil](/molmil-images/mine/1smf) | Studies on an artificial trypsin inhibitor peptide derived from the mung bean inhibitor | 分子名称: | BOWMAN-BIRK TYPE TRYPSIN INHIBITOR, CALCIUM ION, TRYPSIN | 著者 | Huang, Q, Li, Y, Zhang, S, Liu, S, Tang, Y, Qi, C. | 登録日 | 1992-10-24 | 公開日 | 1994-07-31 | 最終更新日 | 2017-06-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Studies on an artificial trypsin inhibitor peptide derived from the mung bean trypsin inhibitor: chemical synthesis, refolding, and crystallographic analysis of its complex with trypsin. J.Biochem.(Tokyo), 116, 1994
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