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PDB: 39 件
6YR5
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BU of 6yr5 by Molmil
14-3-3 sigma in complex with hDMX-367 peptide
分子名称: 14-3-3 protein sigma, Protein Mdm4, SULFATE ION
著者Wolter, M, Srdanovic, S, Ottman, C, Warriner, S, Wilson, A.
登録日2020-04-19
公開日2021-11-03
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study.
Febs J., 2022
2VJF
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BU of 2vjf by Molmil
Crystal Structure of the MDM2-MDMX RING Domain Heterodimer
分子名称: CITRATE ANION, E3 UBIQUITIN-PROTEIN LIGASE MDM2, MDM4 PROTEIN, ...
著者Mace, P.D, Linke, K, Smith, C.A, Day, C.L.
登録日2007-12-10
公開日2008-05-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the Mdm2/Mdmx Ring Domain Heterodimer Reveals Dimerization is Required for Their Ubiquitylation in Trans.
Cell Death Differ., 15, 2008
6Q9U
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BU of 6q9u by Molmil
HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 12 AT 2.4A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-[(4~{S})-5-(5-chloranyl-2-oxidanylidene-1~{H}-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxy-pyrimidin-5-yl]-6-oxidanylidene-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-4-yl]benzenecarbonitrile, CHLORIDE ION, ...
著者Kallen, J.
登録日2018-12-18
公開日2019-05-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.
Chemmedchem, 14, 2019
6Q9S
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BU of 6q9s by Molmil
HDMX (14-111; C17S) COMPLEXED WITH COMPOUND 14 AT 2.4A: Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
分子名称: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3-[[6-chloranyl-3-[3-[(1~{S})-1-(2,4-dichlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]carbonylamino]-4-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]benzoic acid, Protein Mdm4, ...
著者Kallen, J.
登録日2018-12-18
公開日2019-05-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.
Chemmedchem, 14, 2019
5VK1
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BU of 5vk1 by Molmil
Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
分子名称: Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI, Protein Mdm4
著者Tolbert, W.D, Gohain, N, Pazgier, M.
登録日2017-04-20
公開日2018-04-25
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.
Chem Sci, 10, 2019
7KJN
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BU of 7kjn by Molmil
CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
分子名称: D-PMI-omega, Protein Mdm4
著者Tolbert, W.D, Pazgier, M.
登録日2020-10-26
公開日2021-11-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
To Be Published
5UML
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BU of 5uml by Molmil
CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3
分子名称: PEPTIDE INHIBITOR M3, Protein Mdm4
著者Pazgier, M, Gohain, N, Tolbert, W.D.
登録日2017-01-27
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for p53 activation
To Be Published
7MLA
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BU of 7mla by Molmil
Solution NMR structure of HDMX in complex with Zn and MCo-52-2
分子名称: MCo-52-2, Protein Mdm4, ZINC ION
著者Ramirez, L.S, Theophall, G, Chaudhuri, D, Camarero, J.C, Shekhtman, A.
登録日2021-04-28
公開日2022-05-04
実験手法SOLUTION NMR
主引用文献Solution NMR structure of HDMX in complex with Zn and cyclotide 52-2
To Be Published
2N0W
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BU of 2n0w by Molmil
Mdmx-SJ212
分子名称: 4-({(4S,5R)-4-(5-bromo-2-fluorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4
著者Grace, C.R, Kriwacki, R.W.
登録日2015-03-17
公開日2016-01-27
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N06
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BU of 2n06 by Molmil
Mdmx-298
分子名称: 4-[[(4S,5R)-5-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, Protein Mdm4
著者Grace, C.R, Kriwacki, R.W.
登録日2015-03-04
公開日2016-01-27
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N14
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BU of 2n14 by Molmil
Mdmx-295
分子名称: 4-({(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4
著者Grace, C.R, Kriwacki, R.W.
登録日2015-03-20
公開日2016-01-27
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N0U
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BU of 2n0u by Molmil
Mdmx-057
分子名称: 4-[(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-1-(3-oxidanylidenepiperazin-1-yl)carbonyl-4,5-dihydroimidazol-2-yl]-3-propan-2-yloxy-benzenecarbonitrile, Protein Mdm4
著者Grace, C.R, Kriwacki, R.W.
登録日2015-03-17
公開日2016-01-27
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2CR8
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BU of 2cr8 by Molmil
Solution structure of the zf-RanBP domain of p53-binding protein Mdm4
分子名称: Mdm4 protein, ZINC ION
著者Zhang, H.P, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-20
公開日2005-11-20
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the zf-RanBP domain of p53-binding protein Mdm4
To be published
2MWY
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BU of 2mwy by Molmil
Mdmx-p53
分子名称: Cellular tumor antigen p53, Protein Mdm4
著者Grace, C.R.
登録日2014-12-03
公開日2016-01-27
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
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