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PDB: 11 件
9EQH
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WWP2 WW2-2,3-linker-HECT (WWP2-LH)
分子名称: GLYCEROL, Isoform 2 of NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION
著者Dudey, A.P, Hemmings, A.M.
登録日2024-03-21
公開日2024-05-15
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Expanding the Inhibitor Space of the WWP1 and WWP2 HECT E3 Ligases
To Be Published
8EI7
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BU of 8ei7 by Molmil
Crystal structure of the WWP2 HECT domain in complex with H304, a Helicon Polypeptide
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
登録日2022-09-14
公開日2023-10-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
5TJ8
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BU of 5tj8 by Molmil
Structure of WWP2 WW2-2,3-linker-HECT (no WW2 observed)
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION
著者Chen, Z, Gabelli, S.B.
登録日2016-10-03
公開日2017-06-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
4Y07
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Crystal structure of the HECT domain of human WWP2
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2
著者Gong, W, Li, J, Li, Z, Xu, Y.
登録日2015-02-05
公開日2015-11-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.507 Å)
主引用文献Structure of the HECT domain of human WWP2
Acta Crystallogr.,Sect.F, 71, 2015
8EI5
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BU of 8ei5 by Molmil
Crystal structure of the WWP2 HECT domain in complex with H301, a Helicon Polypeptide
分子名称: 1,2-ETHANEDIOL, GLYCEROL, H301, ...
著者Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
登録日2022-09-14
公開日2023-10-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
5TJ7
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Structure of WWP2 WW2-2,3-linker-HECT aa 334-398 linked to 485-865
分子名称: CHLORIDE ION, NEDD4-like E3 ubiquitin-protein ligase WWP2, SODIUM ION, ...
著者Chen, Z, Gabelli, S.B.
登録日2016-10-03
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
6J1Z
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BU of 6j1z by Molmil
WWP2 semi-open conformation
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2
著者Liu, Z.H.
登録日2018-12-30
公開日2019-07-24
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
5TJQ
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BU of 5tjq by Molmil
Structure of WWP2 2,3-linker-HECT
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2,NEDD4-like E3 ubiquitin-protein ligase WWP2
著者Chen, Z, Gabelli, S.B.
登録日2016-10-04
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A Tunable Brake for HECT Ubiquitin Ligases.
Mol. Cell, 66, 2017
8EI8
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BU of 8ei8 by Molmil
Crystal structure of the WWP2 HECT domain in complex with H308, a Helicon Polypeptide
分子名称: 1,2-ETHANEDIOL, H308, N,N'-(1,4-phenylene)diacetamide, ...
著者Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
登録日2022-09-14
公開日2023-10-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
8EI6
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BU of 8ei6 by Molmil
Crystal structure of the WWP2 HECT domain in complex with H305, a Helicon Polypeptide
分子名称: H305, N,N'-(1,4-phenylene)diacetamide, NEDD4-like E3 ubiquitin-protein ligase WWP2
著者Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H.
登録日2022-09-14
公開日2023-10-25
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
6RSS
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BU of 6rss by Molmil
Solution structure of the fourth WW domain of WWP2 with GB1-tag
分子名称: NEDD4-like E3 ubiquitin-protein ligase WWP2
著者Wahl, L.C, Watt, J.E, Tolchard, J, Blumenschein, T.M.A, Chantry, A.
登録日2019-05-22
公開日2019-10-09
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms.
Int J Mol Sci, 20, 2019

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件を2024-07-10に公開中

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