PDB クエリの検索結果 - 日本蛋白質構造データバンク

PDB: 2 件

Rho-associated protein kinase 1 (ROCK 1) in complex with a pyridine thiazole piperidine inhibitor
分子名称:	2-{3-[3-(piperidin-4-yl)propoxy]phenyl}-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide, Rho-associated protein kinase 1
著者	Jacobs, M.J.
登録日	2016-01-28
公開日	2017-02-08
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups. Bioorg. Med. Chem. Lett., 2018

ROCK 1 bound to methoxyphenyl thiazole inhibitor
分子名称:	2-(3-methoxyphenyl)-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide, Rho-associated protein kinase 1
著者	Jacobs, M.D.
登録日	2015-03-19
公開日	2015-06-10
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (3.4 Å)
主引用文献	Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. J.Med.Chem., 58, 2015