1AMO
| THREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMES | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Wang, M, Roberts, D.L, Paschke, R, Shea, T.M, Masters, B.S.S, Kim, J.J.P. | Deposit date: | 1997-06-17 | Release date: | 1998-06-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. Proc.Natl.Acad.Sci.USA, 94, 1997
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1DDI
| CRYSTAL STRUCTURE OF SIR-FP60 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT | Authors: | Gruez, A, Pignol, D, Zeghouf, M, Coves, J, Fontecave, M, Ferrer, J.L, Fontecilla-Camps, J.C. | Deposit date: | 1999-11-10 | Release date: | 2000-11-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module. J.Mol.Biol., 299, 2000
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1DDG
| CRYSTAL STRUCTURE OF SIR-FP60 | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, SULFITE REDUCTASE (NADPH) FLAVOPROTEIN ALPHA-COMPONENT | Authors: | Gruez, A, Pignol, D, Zeghouf, M, Coves, J, Fontecave, M, Ferrer, J.L, Fontecilla-Camps, J.C. | Deposit date: | 1999-11-10 | Release date: | 2000-11-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module. J.Mol.Biol., 299, 2000
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1JA0
| CYPOR-W677X | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Hubbard, P.A, Shen, A.L, Paschke, R, Kasper, C.B, Kim, J.J. | Deposit date: | 2001-05-29 | Release date: | 2001-08-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer. J.Biol.Chem., 276, 2001
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1J9Z
| CYPOR-W677G | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Hubbard, P.A, Shen, A.L, Paschke, R, Kasper, C.B, Kim, J.J. | Deposit date: | 2001-05-29 | Release date: | 2001-08-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer. J.Biol.Chem., 276, 2001
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1JA1
| CYPOR-Triple Mutant | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Hubbard, P.A, Shen, A.L, Paschke, R, Kasper, C.B, Kim, J.J. | Deposit date: | 2001-05-29 | Release date: | 2001-08-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | NADPH-cytochrome P450 oxidoreductase. Structural basis for hydride and electron transfer. J.Biol.Chem., 276, 2001
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1F20
| CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE FAD/NADP+ DOMAIN AT 1.9A RESOLUTION. | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, GLYCEROL, ... | Authors: | Zhang, J, Martasek, P, Masters, B.S, Kim, J.P. | Deposit date: | 2000-05-22 | Release date: | 2001-10-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the FAD/NADPH-binding domain of rat neuronal nitric-oxide synthase. Comparisons with NADPH-cytochrome P450 oxidoreductase. J.Biol.Chem., 276, 2001
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1TLL
| CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION. | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Garcin, E.D, Bruns, C.M, Lloyd, S.J, Hosfield, D.J, Tiso, M, Gachhui, R, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | Deposit date: | 2004-06-09 | Release date: | 2004-08-31 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase J.Biol.Chem., 279, 2004
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2BN4
| A second FMN-binding site in yeast NADPH-cytochrome P450 reductase suggests a novel mechanism of electron transfer by diflavin reductase | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Podust, L.M, Lepesheva, G.I, Kim, Y, Yermalitskaya, L.V, Yermalitsky, V.N, Lamb, D.C, Kelly, S.L, Waterman, M.R. | Deposit date: | 2005-03-18 | Release date: | 2006-01-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | A Second Fmn-Binding Site in Yeast Nadph-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases. Structure, 14, 2006
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2BF4
| A second FMN-binding site in yeast NADPH-cytochrome P450 reductase suggests a novel mechanism of electron transfer by diflavin reductases. | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Podust, L.M, Lepesheva, G.I, Kim, Y, Yermalitskaya, L.V, Yermalitsky, V.N, Lamb, D.C, Kelly, S.L, Waterman, M.R. | Deposit date: | 2004-12-03 | Release date: | 2006-01-17 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Second Fmn-Binding Site in Yeast Nadph-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases. Structure, 14, 2006
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2BPO
| Crystal structure of the yeast CPR triple mutant: D74G, Y75F, K78A. | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Yermalitskaya, L.V, Kim, Y, Waterman, M.R, Podust, L.M. | Deposit date: | 2005-04-21 | Release date: | 2006-07-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of the Yeast Cpr Triple Mutant: D74G, Y75F, K78A. To be Published
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2QTL
| Crystal Structure of the FAD-containing FNR-like Module of Human Methionine Synthase Reductase | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Methionine synthase reductase | Authors: | Wolthers, K.R, Lou, X, Toogood, H.S, Leys, D, Scrutton, N.S. | Deposit date: | 2007-08-02 | Release date: | 2007-11-13 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry Biochemistry, 46, 2007
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2QTZ
| Crystal Structure of the NADP+-bound FAD-containing FNR-like Module of Human Methionine Synthase Reductase | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Methionine synthase reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wolthers, K.R, Lou, X, Toogood, H.S, Leys, D, Scrutton, N.S. | Deposit date: | 2007-08-02 | Release date: | 2007-11-13 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry Biochemistry, 46, 2007
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3ES9
| NADPH-Cytochrome P450 Reductase in an Open Conformation | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Hamdane, D, Xia, C, Im, S.-C, Zhang, H, Kim, J.-J, Waskell, L. | Deposit date: | 2008-10-05 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450 J.Biol.Chem., 284, 2009
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3FJO
| Structure of chimeric YH CPR | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH-cytochrome P450 reductase | Authors: | Morera, S, Aigrain, L, Truan, G. | Deposit date: | 2008-12-15 | Release date: | 2009-06-16 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase Embo Rep., 10, 2009
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3OJX
| Disulfide crosslinked cytochrome P450 reductase inactive | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Xia, C, Hamdane, D, Shen, A, Choi, V, Kasper, C, Zhang, H, Im, S.-C, Waskell, L, Kim, J.-J.P. | Deposit date: | 2010-08-23 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding. J.Biol.Chem., 286, 2011
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3OJW
| Disulfide crosslinked cytochrome P450 reductase inactive | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH-cytochrome P450 reductase | Authors: | Xia, C, Hamdane, D, Shen, A, Choi, V, Kasper, C, Zhang, H, Im, S.-C, Waskell, L, Kim, J.-J.P. | Deposit date: | 2010-08-23 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding. J.Biol.Chem., 286, 2011
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3QE2
| Crystal Structure of Human NADPH-Cytochrome P450 Reductase | Descriptor: | CALCIUM ION, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Xia, C, Marohnic, C, Panda, S.P, Masters, B.S, Kim, J.-J.P. | Deposit date: | 2011-01-19 | Release date: | 2011-08-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc.Natl.Acad.Sci.USA, 108, 2011
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3QFC
| Crystal Structure of Human NADPH-Cytochrome P450 (V492E mutant) | Descriptor: | CALCIUM ION, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Xia, C, Marohnic, C, Panda, S.P, Masters, B.S, Kim, J.-J.P. | Deposit date: | 2011-01-21 | Release date: | 2011-08-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc.Natl.Acad.Sci.USA, 108, 2011
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3QFR
| Crystal Structure of Human NADPH-Cytochrome P450 Reductase (R457H Mutant) | Descriptor: | CALCIUM ION, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Xia, C, Marohnic, C, Panda, S.P, Masters, B.S, Kim, J.-J.P. | Deposit date: | 2011-01-22 | Release date: | 2011-08-03 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc.Natl.Acad.Sci.USA, 108, 2011
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3QFT
| Crystal Structure of NADPH-Cytochrome P450 Reductase (FAD/NADPH domain and R457H Mutant) | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH--cytochrome P450 reductase | Authors: | Xia, C, Marohnic, C, Panda, S.P, Masters, B.S, Kim, J.-J.P. | Deposit date: | 2011-01-22 | Release date: | 2011-08-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc.Natl.Acad.Sci.USA, 108, 2011
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3QFS
| Crystal Structure of NADPH-Cytochrome P450 Reductase (FAD/NADPH domain) | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH--cytochrome P450 reductase | Authors: | Xia, C, Marohnic, C, Panda, S.P, Masters, B.S, Kim, J.-J.P. | Deposit date: | 2011-01-22 | Release date: | 2011-08-17 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc.Natl.Acad.Sci.USA, 108, 2011
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4DQL
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4DQK
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3WKT
| Complex structure of an open form of NADPH-cytochrome P450 reductase and heme oxygenase-1 | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, Heme oxygenase 1, ... | Authors: | Sugishima, M, Sato, H, Higashimoto, Y, Harada, J, Wada, K, Fukuyama, K, Noguchi, M. | Deposit date: | 2013-10-31 | Release date: | 2014-01-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4.3 Å) | Cite: | Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase. Proc.Natl.Acad.Sci.USA, 111, 2014
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