1KPF
 
 | | PKCI-SUBSTRATE ANALOG | | Descriptor: | ADENOSINE MONOPHOSPHATE, PROTEIN KINASE C INTERACTING PROTEIN | | Authors: | Lima, C.D, Klein, M.G, Hendrickson, W.A. | | Deposit date: | 1997-09-25 | | Release date: | 1998-03-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure-based analysis of catalysis and substrate definition in the HIT protein family.
Science, 278, 1997
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2O1L
 | | Structure of a complex of C-terminal lobe of bovine lactoferrin with disaccharide at 1.97 A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... | | Authors: | Singh, N, Sharma, S, Perbandt, M, Kaur, P, Betzel, C, Singh, T.P. | | Deposit date: | 2006-11-29 | | Release date: | 2006-12-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Structure of a complex of C-terminal lobe of bovine lactoferrin with disaccharide at 1.97 A resolution
To be Published
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3PDF
 | | Discovery of Novel Cyanamide-Based Inhibitors of Cathepsin C | | Descriptor: | 2,5-dibromo-N-{(3R,5S)-1-[(Z)-iminomethyl]-5-methylpyrrolidin-3-yl}benzenesulfonamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zhao, B, Laine, D. | | Deposit date: | 2010-10-22 | | Release date: | 2011-10-26 | | Last modified: | 2023-07-26 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Discovery of novel cyanamide-based inhibitors of cathepsin C.
Acs Med.Chem.Lett., 2, 2011
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1XXE
 | | RDC refined solution structure of the AaLpxC/TU-514 complex | | Descriptor: | 1,5-ANHYDRO-2-C-(CARBOXYMETHYL-N-HYDROXYAMIDE)-2-DEOXY-3-O-MYRISTOYL-D-GLUCITOL, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION | | Authors: | Coggins, B.E, McClerren, A.L, Jiang, L, Li, X, Rudolph, J, Hindsgaul, O, Raetz, C.R.H, Zhou, P. | | Deposit date: | 2004-11-04 | | Release date: | 2004-11-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Refined Solution Structure of the LpxC-TU-514 Complex and pK(a) Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design
Biochemistry, 44, 2005
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6KKP
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1LJ7
 | | Crystal structure of calcium-depleted human C-reactive protein from perfectly twinned data | | Descriptor: | C-reactive protein | | Authors: | Ramadan, M.A, Shrive, A.K, Holden, D, Myles, D.A, Volanakis, J.E, DeLucas, L.J, Greenhough, T.J. | | Deposit date: | 2002-04-19 | | Release date: | 2002-06-05 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | The three-dimensional structure of calcium-depleted human C-reactive protein from perfectly twinned crystals.
Acta Crystallogr.,Sect.D, 58, 2002
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4GV9
 | | Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min | | Descriptor: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | | Deposit date: | 2012-08-30 | | Release date: | 2013-05-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
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4K1X
 | | Ferredoxin-NADP(H) Reductase mutant with Ala 266 replaced by Tyr (A266Y) and residues 267-272 deleted. | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADPH:ferredoxin reductase, SULFATE ION | | Authors: | Bortolotti, A, Sanchez-Azqueta, A, Maya, C.M, Velazquez-Campoy, A, Hermoso, J.A, Cortez, N. | | Deposit date: | 2013-04-06 | | Release date: | 2013-11-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The C-terminal extension of bacterial flavodoxin-reductases: Involvement in the hydride transfer mechanism from the coenzyme.
Biochim.Biophys.Acta, 1837, 2013
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3PSJ
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4CJO
 | | Spectroscopically-validated structure of ferrous cytochrome c prime from Alcaligenes xylosoxidans, reduced at 180K using X-rays | | Descriptor: | CYTOCHROME C', HEME C | | Authors: | Kekilli, D, Dworkowski, F, Antonyuk, S, Hough, M.A. | | Deposit date: | 2013-12-21 | | Release date: | 2014-05-21 | | Last modified: | 2020-03-11 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Fingerprinting Redox and Ligand States in Haemprotein Crystal Structures Using Resonance Raman Spectroscopy.
Acta Crystallogr.,Sect.D, 70, 2014
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1KPE
 | | PKCI-TRANSITION STATE ANALOG | | Descriptor: | ADENOSINE-5'-DITUNGSTATE, PROTEIN KINASE C INTERACTING PROTEIN | | Authors: | Lima, C.D, Klein, M.G, Hendrickson, W.A. | | Deposit date: | 1997-09-25 | | Release date: | 1998-03-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure-based analysis of catalysis and substrate definition in the HIT protein family.
Science, 278, 1997
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3BRP
 | | Crystal Structure of C-Phycocyanin from Galdieria sulphuraria | | Descriptor: | BILIVERDINE IX ALPHA, C-phycocyanin alpha chain, C-phycocyanin beta chain | | Authors: | Fromme, R. | | Deposit date: | 2007-12-21 | | Release date: | 2009-02-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structure of C-Phycocyanin from Galdieria sulphuraria at 1.85 A
To be Published
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4OTM
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3AFG
 | | Crystal structure of ProN-Tk-SP from Thermococcus kodakaraensis | | Descriptor: | CALCIUM ION, Subtilisin-like serine protease | | Authors: | Foophow, T, Tanaka, S, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | | Deposit date: | 2010-03-01 | | Release date: | 2010-08-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of a subtilisin homologue, Tk-SP, from Thermococcus kodakaraensis: requirement of a C-terminal beta-jelly roll domain for hyperstability.
J.Mol.Biol., 400, 2010
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4JMY
 | | Crystal structure of HCV NS3/NS4A protease complexed with DDIVPC peptide | | Descriptor: | HCV non-structural protein 4A, Polyprotein, SODIUM ION, ... | | Authors: | Lemke, C.T. | | Deposit date: | 2013-03-14 | | Release date: | 2013-10-30 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Importance of the peptide scaffold of drugs that target the hepatitis C virus NS3 protease and its crucial bioactive conformation and dynamic factors.
To be Published
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4CX9
 | | The 5-coordinate proximal NO complex of cytochrome c prime from Shewanella frigidimarina | | Descriptor: | CYTOCHROME C, CLASS II, GLYCEROL, ... | | Authors: | Manole, A.A, Kekilli, D, Dobbin, P.S, Hough, M.A. | | Deposit date: | 2014-04-04 | | Release date: | 2015-04-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Conformational Control of the Binding of Diatomic Gases to Cytochrome C'.
J.Biol.Inorg.Chem., 20, 2015
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1V0C
 | | Structure of AAC(6')-Ib in complex with Kanamycin C and AcetylCoA. | | Descriptor: | AAC(6')-IB, ACETYL COENZYME *A, CALCIUM ION, ... | | Authors: | Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S. | | Deposit date: | 2008-03-20 | | Release date: | 2008-09-02 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant.
Biochemistry, 47, 2008
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4OTN
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1Z60
 | | Solution structure of the carboxy-terminal domain of human TFIIH P44 subunit | | Descriptor: | TFIIH basal transcription factor complex p44 subunit, ZINC ION | | Authors: | Kellenberger, E, Dominguez, C, Fribourg, S, Wasielewski, E, Moras, D, Poterszman, A, Boelens, R, Kieffer, B. | | Deposit date: | 2005-03-21 | | Release date: | 2005-04-12 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions.
J.Biol.Chem., 280, 2005
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2OHY
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2FIM
 | | Structure of the C-terminal domain of Human Tubby-like protein 1 | | Descriptor: | 3-(N,N-DIMETHYLOCTYLAMMONIO)PROPANESULFONATE, SULFATE ION, Tubby related protein 1 | | Authors: | Hallberg, B.M, Ogg, D, Arrowsmith, C, Berglund, H, Edwards, A, Ehn, M, Flodin, S, Graslund, S, Hammarstrom, M, Hogbom, M, Holmberg-Schiavone, L, Kotenyova, T, Kursula, P, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Persson, C. | | Deposit date: | 2005-12-29 | | Release date: | 2006-02-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of the C-terminal domain of Human Tubby-like protein 1
To be published
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2DJG
 | | Re-determination of the native structure of human dipeptidyl peptidase I (cathepsin C) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Dipeptidyl-peptidase 1, ... | | Authors: | Molgaard, A, Arnau, J, Lauritzen, C, Larsen, S, Petersen, G, Pedersen, J. | | Deposit date: | 2006-04-02 | | Release date: | 2006-11-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2
Biochem.J., 401, 2007
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2ORL
 | | Solution structure of the cytochrome c- para-aminophenol adduct | | Descriptor: | 4-AMINOPHENOL, Cytochrome c iso-1, HEME C | | Authors: | Assfalg, M, Bertini, I, Del Conte, R, Giachetti, A, Turano, P. | | Deposit date: | 2007-02-03 | | Release date: | 2007-04-24 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | Cytochrome c and organic molecules: solution structure of the p-aminophenol adduct.
Biochemistry, 46, 2007
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2FAK
 | | Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome | | Descriptor: | (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE, Proteasome component C1, Proteasome component C11, ... | | Authors: | Groll, M, Potts, B.C. | | Deposit date: | 2005-12-07 | | Release date: | 2006-04-18 | | Last modified: | 2023-05-31 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.
J.Am.Chem.Soc., 128, 2006
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2FIB
 | | RECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) COMPLEXED TO THE PEPTIDE GLY-PRO-ARG-PRO AT PH 6.0 | | Descriptor: | CALCIUM ION, FIBRINOGEN, GLY-PRO-ARG-PRO | | Authors: | Pratt, K.P, Cote, H.C.F, Chung, D.W, Stenkamp, R.E, Davie, E.W. | | Deposit date: | 1997-06-03 | | Release date: | 1997-10-15 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.
Proc.Natl.Acad.Sci.USA, 94, 1997
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