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6I0B
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BU of 6i0b by Molmil
Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor.
Descriptor: (2~{S})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Brazzolotto, X, Nachon, F.
Deposit date:2018-10-25
Release date:2019-03-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.384 Å)
Cite:Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Eur.J.Med.Chem., 168, 2019
6K1B
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BU of 6k1b by Molmil
Crystal structure of EXD2 exonuclease domain soaked in Mn and dGMP
Descriptor: Exonuclease 3'-5' domain-containing protein 2, MANGANESE (II) ION
Authors:Park, J, Lee, C.
Deposit date:2019-05-10
Release date:2019-05-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.605 Å)
Cite:The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
6KBN
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BU of 6kbn by Molmil
Crystal structure of Vac8 (del 19-33) bound to Atg13
Descriptor: Autophagy-related protein 13, Vacuolar protein 8
Authors:Park, J, Lee, C.
Deposit date:2019-06-25
Release date:2019-11-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways.
Autophagy, 16, 2020
4H39
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BU of 4h39 by Molmil
Crystal Structure of JNK3 in Complex with JIP1 Peptide
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10
Authors:Nwachukwu, J.C, Laughlin, J.D, Figuera-Losada, M, Cherry, L, Nettles, K.W, LoGrasso, P.V.
Deposit date:2012-09-13
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.992 Å)
Cite:Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases.
Structure, 20, 2012
7VWX
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BU of 7vwx by Molmil
CryoEM structure of football-shaped GroEL:ES2 with RuBisCO
Descriptor: Chaperonin GroEL, Co-chaperonin GroES, Ribulose bisphosphate carboxylase
Authors:Kim, H, Roh, S.H.
Deposit date:2021-11-12
Release date:2022-01-12
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Cryo-EM structures of GroEL:ES 2 with RuBisCO visualize molecular contacts of encapsulated substrates in a double-cage chaperonin.
Iscience, 25, 2022
7X14
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BU of 7x14 by Molmil
Crystal structure of phospho-FFAT motif of MIGA2 bound to VAPB
Descriptor: MIGA2 phospho FFAT motif, SULFATE ION, Vesicle-associated membrane protein-associated protein B
Authors:Kim, H, Lee, C.
Deposit date:2022-02-23
Release date:2022-09-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.675 Å)
Cite:Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
7X15
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BU of 7x15 by Molmil
Crystal structure of MIGA2 LD targeting domain
Descriptor: DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, FORMIC ACID, Mitoguardin 2
Authors:Kim, H, Lee, C.
Deposit date:2022-02-23
Release date:2022-09-14
Method:X-RAY DIFFRACTION (2.852 Å)
Cite:Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.
Nat Commun, 13, 2022
7YCJ
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BU of 7ycj by Molmil
Crystal structure of Vac8 bound to Vac17
Descriptor: Vacuolar protein 8, vacuole-related protein 17
Authors:Kim, H, Kim, H, Lee, C.
Deposit date:2022-07-01
Release date:2023-07-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Crystal structure of Vac8 bound to Vac17
To Be Published
8GW7
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BU of 8gw7 by Molmil
AtSLAC1 6D mutant in open state
Descriptor: CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment)
Authors:Lee, Y, Lee, S.
Deposit date:2022-09-16
Release date:2023-11-15
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
8GW6
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BU of 8gw6 by Molmil
AtSLAC1 6D mutant in closed state
Descriptor: CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein (Fragment)
Authors:Lee, Y, Lee, S.
Deposit date:2022-09-16
Release date:2023-11-15
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
3O2M
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BU of 3o2m by Molmil
Crystal Structure of JNK1-alpha1 isoform complex with a biaryl tetrazol (A-82118)
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE, ...
Authors:Abad-Zapatero, C.
Deposit date:2010-07-22
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
Acs Chem.Biol., 6, 2011
8J0J
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BU of 8j0j by Molmil
AtSLAC1 8D mutant in closed state
Descriptor: CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein
Authors:Lee, Y, Lee, S.
Deposit date:2023-04-11
Release date:2023-11-22
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
8J1E
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BU of 8j1e by Molmil
AtSLAC1 in open state
Descriptor: CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, Guard cell S-type anion channel SLAC1,Green fluorescent protein
Authors:Lee, Y, Lee, S.
Deposit date:2023-04-12
Release date:2023-11-22
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.84 Å)
Cite:Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Nat Commun, 14, 2023
4DK1
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BU of 4dk1 by Molmil
Crystal Structure of MacA-MexA chimeric protein, containing the Pseudomonas aeruginosa MexA alpha-hairpin domain.
Descriptor: Putative MacA, Multidrug resistance protein mexA
Authors:Xu, Y, Ha, N.C.
Deposit date:2012-02-03
Release date:2012-03-07
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.499 Å)
Cite:Assembly and channel opening of outer membrane protein in tripartite drug efflux pumps of Gram-negative bacteria.
J.Biol.Chem., 287, 2012
4DK0
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BU of 4dk0 by Molmil
Crystal structure of MacA from Actinobacillus actinomycetemcomitans
Descriptor: Putative MacA
Authors:Xu, Y, Piao, S, Ha, N.C.
Deposit date:2012-02-03
Release date:2012-03-07
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and channel opening of outer membrane protein in tripartite drug efflux pumps of Gram-negative bacteria.
J.Biol.Chem., 287, 2012
3PTG
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BU of 3ptg by Molmil
Design and Synthesis of a Novel, Orally Efficacious Tri-substituted Thiophene Based JNK Inhibitor
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 10, N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide
Authors:Bowers, S, Truong, A.P, Neitz, J, Neitzel, M, Probst, G.D, Hom, R.K, Konradi, A.W, Sham, H.L, Toth, G, Pan, H, Yao, N, Artis, D.R, Brigham, E.F, Quinn, K.P, Sauer, J, Powell, K, Ruslim, L, Bard, F, Yednock, T.A, Griswold-Prenner, I.
Deposit date:2010-12-02
Release date:2011-03-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.
Bioorg.Med.Chem.Lett., 21, 2011
3U86
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BU of 3u86 by Molmil
Crystal structure of human menin in complex with JunD
Descriptor: Menin, Transcription factor jun-D
Authors:Huang, J, Wan, B, Lei, M.
Deposit date:2011-10-15
Release date:2012-02-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.843 Å)
Cite:The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature, 482, 2012
3Q8W
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BU of 3q8w by Molmil
A b-aminoacyl containing thiazolidine derivative and DPPIV complex
Descriptor: Dipeptidyl peptidase 4, N-(4-{[({(2R)-3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidin-2-yl}carbonyl)amino]methyl}phenyl)-D-valine
Authors:Lee, J.O, Song, D.H.
Deposit date:2011-01-07
Release date:2011-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:Discovery of b-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors
To be Published
3QQU
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BU of 3qqu by Molmil
Cocrystal structure of unphosphorylated igf with pyrimidine 8
Descriptor: Insulin-like growth factor 1 receptor, N~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-N~4~-(quinolin-3-yl)pyrimidine-2,4-diamine
Authors:Huang, X.
Deposit date:2011-02-16
Release date:2011-04-20
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
2J9F
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BU of 2j9f by Molmil
Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase E1b
Descriptor: 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, C2-1-HYDROXY-3-METHYL-PROPYL-THIAMIN DIPHOSPHATE, ...
Authors:Jun, L, Machius, M, Chuang, J.L, Wynn, R.M, Chuang, D.T.
Deposit date:2006-11-07
Release date:2007-02-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The Two Active Sites in Human Branched-Chain Alpha- Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-Site Mechanism.
J.Biol.Chem., 282, 2007
7XMH
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BU of 7xmh by Molmil
Crystal structure of a rice class IIIb chitinase, Oschib2
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Putative class III chitinase
Authors:Jun, T, Tomoya, T, Tomoyuki, N, Takayuki, O.
Deposit date:2022-04-25
Release date:2023-05-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Characterization of two rice GH18 chitinases belonging to family 8 of plant pathogenesis-related proteins.
Plant Sci., 326, 2023
4W4X
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BU of 4w4x by Molmil
JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
Descriptor: 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
Authors:Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4UX9
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BU of 4ux9 by Molmil
Crystal structure of JNK1 bound to a MKK7 docking motif
Descriptor: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7, MITOGEN-ACTIVATED PROTEIN KINASE 8, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Kragelj, J, Palencia, A, Nanao, M.H, Maurin, D, Bouvignies, G, Blackledge, M, Ringkjobing-Jensen, M.
Deposit date:2014-08-20
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure and Dynamics of the Mkk7-Jnk Signaling Complex.
Proc.Natl.Acad.Sci.USA, 112, 2015
4W4Y
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BU of 4w4y by Molmil
JNK2/3 in complex with 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
Descriptor: 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
Authors:Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
6L6Z
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BU of 6l6z by Molmil
Cryo-EM structure of the Drosophila CTP synthase substrate-bound filament
Descriptor: CTP synthase
Authors:Ji-Long, L, Xian, Z, Chen-Jun, G.
Deposit date:2019-10-30
Release date:2020-03-18
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (6.09 Å)
Cite:Drosophila CTP synthase can form distinct substrate- and product-bound filaments.
J Genet Genomics, 46, 2019

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