7MNZ
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![BU of 7mnz by Molmil](/molmil-images/mine/7mnz) | Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP | Descriptor: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNX
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![BU of 7mnx by Molmil](/molmil-images/mine/7mnx) | Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP | Descriptor: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNY
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![BU of 7mny by Molmil](/molmil-images/mine/7mny) | Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP | Descriptor: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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5ZYM
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![BU of 5zym by Molmil](/molmil-images/mine/5zym) | Crystal structure of CERT START domain in complex with compound E25B | Descriptor: | 2-[4-[4-cyclopentyl-3-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL, LIPID-TRANSFER PROTEIN CERT | Authors: | Suzuki, M, Nakao, N, Ueno, M, Sakai, S, Egawa, D, Hanzawa, H, Kawasaki, S, Kumagai, K, Kobayashi, S, Hanada, K. | Deposit date: | 2018-05-25 | Release date: | 2019-02-27 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT Commun Chem, 2019
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6R2X
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![BU of 6r2x by Molmil](/molmil-images/mine/6r2x) | NMR structure of Chromogranin A (F39-D63) | Descriptor: | Chromogranin-A | Authors: | Nardelli, F, Quilici, G, Ghitti, M, Curnis, F, Gori, A, Berardi, A, Corti, A, Musco, G. | Deposit date: | 2019-03-19 | Release date: | 2019-12-04 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | A stapled chromogranin A-derived peptide is a potent dual ligand for integrins alpha v beta 6 and alpha v beta 8. Chem.Commun.(Camb.), 55, 2019
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5VYQ
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![BU of 5vyq by Molmil](/molmil-images/mine/5vyq) | Crystal structure of the N-formyltransferase Rv3404c from mycobacterium tuberculosis in complex with YDP-Qui4N and folinic acid | Descriptor: | 1,2-ETHANEDIOL, 3-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONIC ACID, CHLORIDE ION, ... | Authors: | Dunsirn, M.M, Thoden, J.B, Holden, H.M. | Deposit date: | 2017-05-26 | Release date: | 2017-07-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis. Biochemistry, 56, 2017
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4TV8
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![BU of 4tv8 by Molmil](/molmil-images/mine/4tv8) | Tubulin-Maytansine complex | Descriptor: | (3beta,4beta,5beta,10beta,11E,13E)-maytansine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Prota, A.E, Bargsten, K, Diaz, J.F, Marsh, M, Cuevas, C, Liniger, M, Neuhaus, C, Andreu, J.M, Altmann, K.H, Steinmetz, M.O. | Deposit date: | 2014-06-26 | Release date: | 2014-08-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111, 2014
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8HCZ
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![BU of 8hcz by Molmil](/molmil-images/mine/8hcz) | |
6XFO
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![BU of 6xfo by Molmil](/molmil-images/mine/6xfo) | |
8HD4
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![BU of 8hd4 by Molmil](/molmil-images/mine/8hd4) | Full-length crystal structure of mycobacterium tuberculosis FadD23 in complex with AMPC16 | Descriptor: | Long-chain-fatty-acid--AMP ligase FadD23, palmitoyl adenylate | Authors: | Yan, M.R, Liu, X, Zhang, W, Rao, Z.H. | Deposit date: | 2022-11-03 | Release date: | 2023-02-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | The Key Roles of Mycobacterium tuberculosis FadD23 C-terminal Domain in Catalytic Mechanisms. Front Microbiol, 14, 2023
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1U0X
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![BU of 1u0x by Molmil](/molmil-images/mine/1u0x) | Crystal structure of nitrophorin 4 under pressure of xenon (200 psi) | Descriptor: | AMMONIA, Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Nienhaus, K, Maes, E.M, Weichsel, A, Montfort, W.R, Nienhaus, G.U. | Deposit date: | 2004-07-14 | Release date: | 2004-07-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structural dynamics controls nitric oxide affinity in nitrophorin 4 J.Biol.Chem., 279, 2004
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2IZJ
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![BU of 2izj by Molmil](/molmil-images/mine/2izj) | STREPTAVIDIN-BIOTIN PH 3.50 I4122 STRUCTURE | Descriptor: | BIOTIN, STREPTAVIDIN | Authors: | Katz, B.A. | Deposit date: | 1997-08-13 | Release date: | 1998-09-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH. J.Mol.Biol., 274, 1997
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2IZL
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![BU of 2izl by Molmil](/molmil-images/mine/2izl) | STREPTAVIDIN-2-IMINOBIOTIN PH 7.3 I222 COMPLEX | Descriptor: | 2-IMINOBIOTIN, STREPTAVIDIN | Authors: | Katz, B.A. | Deposit date: | 1997-08-13 | Release date: | 1998-09-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH. J.Mol.Biol., 274, 1997
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2IZI
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![BU of 2izi by Molmil](/molmil-images/mine/2izi) | STREPTAVIDIN-BIOTIN PH 2.53 I4122 STRUCTURE | Descriptor: | BIOTIN, STREPTAVIDIN | Authors: | Katz, B.A. | Deposit date: | 1997-08-13 | Release date: | 1998-09-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH. J.Mol.Biol., 274, 1997
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2IZH
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![BU of 2izh by Molmil](/molmil-images/mine/2izh) | STREPTAVIDIN-BIOTIN PH 10.44 I222 COMPLEX | Descriptor: | BIOTIN, STREPTAVIDIN | Authors: | Katz, B.A. | Deposit date: | 1997-08-13 | Release date: | 1998-09-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH. J.Mol.Biol., 274, 1997
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8IFD
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![BU of 8ifd by Molmil](/molmil-images/mine/8ifd) | Dibekacin-added human 80S ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Tomono, J, Asano, K, Chiashi, T, Tanaka, Y, Yokoyama, T. | Deposit date: | 2023-02-17 | Release date: | 2024-02-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside. J.Biochem., 175, 2024
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4MLT
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![BU of 4mlt by Molmil](/molmil-images/mine/4mlt) | |
2YAT
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![BU of 2yat by Molmil](/molmil-images/mine/2yat) | Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex | Descriptor: | ESTRADIOL-PYRIDINIUM TETRAACETIC ACID, ESTROGEN RECEPTOR, EUROPIUM ION, ... | Authors: | Li, M.J, Greenblatt, H.M, Dym, O, Albeck, S, Degani, H, Sussman, J.L. | Deposit date: | 2011-02-24 | Release date: | 2011-06-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.602 Å) | Cite: | Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators. J.Med.Chem., 54, 2011
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5FHM
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![BU of 5fhm by Molmil](/molmil-images/mine/5fhm) | Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution | Descriptor: | (2~{S})-3-[5-[2-[[3-(aminomethyl)phenyl]methyl]-1,2,3,4-tetrazol-5-yl]-3-oxidanyl-1,2-oxazol-4-yl]-2-azanyl-propanoic acid, 1,2-ETHANEDIOL, ACETATE ION, ... | Authors: | Kastrup, J.S, Frydenvang, K, Al-musaed, A. | Deposit date: | 2015-12-22 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016
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8QBU
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![BU of 8qbu by Molmil](/molmil-images/mine/8qbu) | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR CX-4945 AND THE ALPHA-D-POCKET LIGAND 3,4-DICHLORO PHENETHYLAMINE (DPA) | Descriptor: | 1,2-ETHANEDIOL, 2-(3,4-dichlorophenyl)ethanamine, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, ... | Authors: | Werner, C, Niefind, K. | Deposit date: | 2023-08-25 | Release date: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool Kinases Phosphatases, 2023
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1P1U
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2P1U
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![BU of 2p1u by Molmil](/molmil-images/mine/2p1u) | Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-ethoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2 | Descriptor: | (2E)-3-[3-(3-ETHOXY-5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-4-HYDROXYPHENYL]ACRYLIC ACID, Nuclear receptor coactivator 2 peptide, Retinoic acid receptor RXR-alpha | Authors: | Bourguet, W, Nahoum, V. | Deposit date: | 2007-03-06 | Release date: | 2007-10-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci.Usa, 104, 2007
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8IFE
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![BU of 8ife by Molmil](/molmil-images/mine/8ife) | Arbekacin-added human 80S ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | Authors: | Tomono, J, Asano, K, Chiashi, T, Tanaka, Y, Yokoyama, T. | Deposit date: | 2023-02-17 | Release date: | 2024-02-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Direct visualization of ribosomes in the cell-free system revealed the functional evolution of aminoglycoside. J.Biochem., 175, 2024
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8AZB
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3OK9
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![BU of 3ok9 by Molmil](/molmil-images/mine/3ok9) | Crystal structure of wild-type HIV-1 protease with new oxatricyclic designed inhibitor GRL-0519A | Descriptor: | (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, CHLORIDE ION, GLYCEROL, ... | Authors: | Wang, Y.-F, Agniswamy, J, Weber, I.T. | Deposit date: | 2010-08-24 | Release date: | 2010-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors. Chemmedchem, 5, 2010
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