6R2X
NMR structure of Chromogranin A (F39-D63)
Summary for 6R2X
| Entry DOI | 10.2210/pdb6r2x/pdb |
| NMR Information | BMRB: 34381 |
| Descriptor | Chromogranin-A (1 entity in total) |
| Functional Keywords | fragment of chromogranin a, ligand of alpha v beta 6, interactors, hormone |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 3042.47 |
| Authors | Nardelli, F.,Quilici, G.,Ghitti, M.,Curnis, F.,Gori, A.,Berardi, A.,Corti, A.,Musco, G. (deposition date: 2019-03-19, release date: 2019-12-04, Last modification date: 2024-06-19) |
| Primary citation | Nardelli, F.,Ghitti, M.,Quilici, G.,Gori, A.,Luo, Q.,Berardi, A.,Sacchi, A.,Monieri, M.,Bergamaschi, G.,Bermel, W.,Chen, F.,Corti, A.,Curnis, F.,Musco, G. A stapled chromogranin A-derived peptide is a potent dual ligand for integrins alpha v beta 6 and alpha v beta 8. Chem.Commun.(Camb.), 55:14777-14780, 2019 Cited by PubMed Abstract: Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications. PubMed: 31755501DOI: 10.1039/c9cc08518a PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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