6XBY
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![BU of 6xby by Molmil](/molmil-images/mine/6xby) | Cryo-EM structure of V-ATPase from bovine brain, state 2 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Wang, R, Li, X. | Deposit date: | 2020-06-07 | Release date: | 2020-08-19 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Cryo-EM structures of intact V-ATPase from bovine brain. Nat Commun, 11, 2020
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6ZAY
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![BU of 6zay by Molmil](/molmil-images/mine/6zay) | Crystal structure of Atg16L in complex with GDP-bound Rab33B | Descriptor: | 1,2-ETHANEDIOL, Autophagy-related protein 16-1, DI(HYDROXYETHYL)ETHER, ... | Authors: | Pantoom, S, Wu, Y.W. | Deposit date: | 2020-06-06 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein. Autophagy, 17, 2021
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7C97
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![BU of 7c97 by Molmil](/molmil-images/mine/7c97) | |
6ZA8
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![BU of 6za8 by Molmil](/molmil-images/mine/6za8) | Crystal structure of the neurotensin receptor 1 in complex with the small-molecule partial agonist RTI-3a | Descriptor: | (2~{S})-2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]-4-methyl-pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1),Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1) | Authors: | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | Deposit date: | 2020-06-05 | Release date: | 2021-02-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6XAY
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![BU of 6xay by Molmil](/molmil-images/mine/6xay) | Structure of a fragment of human fibronectin containing the 10th, 11th and 12th type III domains | Descriptor: | Fibronectin, GLYCEROL | Authors: | Mou, T.C, Nepomuceno, P.A, Sprang, S.R, Briknarova, K. | Deposit date: | 2020-06-05 | Release date: | 2021-06-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Fragment of human fibronectin containing the 10th, 11th and 12th type III domains To Be Published
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6Z9S
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![BU of 6z9s by Molmil](/molmil-images/mine/6z9s) | Transcription termination intermediate complex 4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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6Z9R
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![BU of 6z9r by Molmil](/molmil-images/mine/6z9r) | Transcription termination intermediate complex 3 | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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6XAS
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![BU of 6xas by Molmil](/molmil-images/mine/6xas) | CryoEM Structure of E. coli Rho-dependent Transcription Pre-termination Complex | Descriptor: | DNA (29-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Hao, Z.T, Kim, H.K, Walz, T, Nudler, E. | Deposit date: | 2020-06-04 | Release date: | 2020-12-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Pre-termination Transcription Complex: Structure and Function. Mol.Cell, 81, 2021
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6XAX
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![BU of 6xax by Molmil](/molmil-images/mine/6xax) | Structure of a fragment of human fibronectin containing the 11th type III domain, extra domain A, and the 12th type III domain | Descriptor: | Fibronectin, GLYCEROL | Authors: | Mou, T.C, Nepomuceno, P.A, Sprang, S.R, Briknarova, K. | Deposit date: | 2020-06-04 | Release date: | 2021-06-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Fragment of human fibronectin containing the 11th type III domain, extra domain A, and 12th type III domain To Be Published
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6XAV
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![BU of 6xav by Molmil](/molmil-images/mine/6xav) | CryoEM Structure of E. coli Rho-dependent Transcription Pre-termination Complex bound with NusG | Descriptor: | DNA (29-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Hao, Z.T, Kim, H.K, Walz, T, Nudler, E. | Deposit date: | 2020-06-04 | Release date: | 2020-12-16 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (7.7 Å) | Cite: | Pre-termination Transcription Complex: Structure and Function. Mol.Cell, 81, 2021
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6Z9T
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![BU of 6z9t by Molmil](/molmil-images/mine/6z9t) | Transcription termination intermediate complex 5 | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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6Z9P
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![BU of 6z9p by Molmil](/molmil-images/mine/6z9p) | Transcription termination intermediate complex 1 | Descriptor: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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6Z9Q
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![BU of 6z9q by Molmil](/molmil-images/mine/6z9q) | Transcription termination intermediate complex 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, M.C. | Deposit date: | 2020-06-04 | Release date: | 2020-11-04 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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6XA2
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![BU of 6xa2 by Molmil](/molmil-images/mine/6xa2) | Structure of the tirandamycin C-bound P450 monooxygenase TamI | Descriptor: | (3E)-3-{(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1R,3R,4S,5R)-1,4,8-trimethyl-2,9-dioxabicyclo[3.3.1]non-7-en-3-yl]hepta-2,4-dien-1-ylidene}-2H-pyrrole-2,4(3H)-dione, PROTOPORPHYRIN IX CONTAINING FE, TamI | Authors: | Newmister, S.A, Srivastava, K.R, Espinoza, R.V, Haatveit, K.C, Khatri, Y, Martini, R.M, Garcia-Borras, M, Podust, L.M, Houk, K.N, Sherman, D.H. | Deposit date: | 2020-06-03 | Release date: | 2021-06-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway. Acs Catalysis, 10, 2020
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6XA3
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![BU of 6xa3 by Molmil](/molmil-images/mine/6xa3) | Structure of the ligand free P450 monooxygenase TamI | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, TamI | Authors: | Newmister, S.A, Srivastava, K.R, Espinoza, R.V, Haatveit, K.C, Khatri, Y, Martini, R.M, Garcia-Borras, M, Podust, L.M, Houk, K.N, Sherman, D.H. | Deposit date: | 2020-06-03 | Release date: | 2021-06-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway. Acs Catalysis, 10, 2020
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6Z7Z
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![BU of 6z7z by Molmil](/molmil-images/mine/6z7z) | |
6Z7W
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![BU of 6z7w by Molmil](/molmil-images/mine/6z7w) | Human insulin in complex with the analytical antibody HUI-018 Fab | Descriptor: | HUI-018 Fab Heavy Chain, Insulin, MAb 6H10 light chain | Authors: | Johansson, E. | Deposit date: | 2020-06-02 | Release date: | 2020-12-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
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6Z84
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![BU of 6z84 by Molmil](/molmil-images/mine/6z84) | CK2 alpha bound to chemical probe SGC-CK2-1 derivative | Descriptor: | Casein kinase II subunit alpha, SULFATE ION, ~{N}-[1-[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]indol-6-yl]ethanamide | Authors: | Kraemer, A, Wells, C, Drewry, D.H, Pickett, J.E, Axtman, A.D, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2020-06-02 | Release date: | 2020-07-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol, 28, 2021
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6Z8X
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![BU of 6z8x by Molmil](/molmil-images/mine/6z8x) | X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3Leu), which contains leucyl amide in the side chain of Thy3 at N3. | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ... | Authors: | Troisi, R, Timofeev, E.N, Sica, F. | Deposit date: | 2020-06-02 | Release date: | 2021-01-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. Mol Ther Nucleic Acids, 23, 2021
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6Z8V
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![BU of 6z8v by Molmil](/molmil-images/mine/6z8v) | X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3L), which contains 1-beta-D-lactopyranosyl residue in the side chain of Thy3 at N3. | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ... | Authors: | Troisi, R, Timofeev, E.N, Sica, F. | Deposit date: | 2020-06-02 | Release date: | 2021-01-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. Mol Ther Nucleic Acids, 23, 2021
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6Z8N
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![BU of 6z8n by Molmil](/molmil-images/mine/6z8n) | Crystal structure of the neurotensin receptor 1 in complex with the small-molecule full agonist SRI-9829 | Descriptor: | (2~{S})-4-methyl-2-[(1-quinolin-8-ylsulfonylindol-3-yl)carbonylamino]pentanoic acid, Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor type 1,Neurotensin receptor 1 (NTSR1),Neurotensin receptor 1 (NTSR1) | Authors: | Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A. | Deposit date: | 2020-06-02 | Release date: | 2021-02-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.803 Å) | Cite: | Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism. Sci Adv, 7, 2021
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6X90
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![BU of 6x90 by Molmil](/molmil-images/mine/6x90) | |
6Z7Y
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![BU of 6z7y by Molmil](/molmil-images/mine/6z7y) | Human insulin in complex with the analytical antibody OXI-005 Fab | Descriptor: | Insulin, OXI-005 Fab Heavy chain, OXI-005 Fab Light chain | Authors: | Johansson, E. | Deposit date: | 2020-06-02 | Release date: | 2020-12-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
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6Z83
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![BU of 6z83 by Molmil](/molmil-images/mine/6z83) | CK2 alpha bound to chemical probe SGC-CK2-1 | Descriptor: | Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | Authors: | Kraemer, A, Wells, C, Drewry, D.H, Pickett, J.E, Axtman, A.D, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2020-06-02 | Release date: | 2020-07-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.171 Å) | Cite: | Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol, 28, 2021
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6Z8W
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![BU of 6z8w by Molmil](/molmil-images/mine/6z8w) | X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3G), which contains 1-beta-D-glucopyranosyl residue in the side chain of Thy3 at N3. | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ... | Authors: | Troisi, R, Timofeev, E.N, Sica, F. | Deposit date: | 2020-06-02 | Release date: | 2021-01-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. Mol Ther Nucleic Acids, 23, 2021
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