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5MKZ
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N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(((3-methylthiophen-2-yl)methyl)amino)pyridazin-3(2H)-one
Descriptor: 4-chloranyl-2-methyl-5-[(3-methylthiophen-2-yl)methylamino]pyridazin-3-one, Bromodomain-containing protein 4, GLYCEROL
Authors:Chung, C.-W.
Deposit date:2016-12-05
Release date:2017-12-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
J. Med. Chem., 60, 2017
5ML0
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Bromodomain of Mouse PCAF with (R)-4-chloro-2-methyl-5-((1-methylpiperidin-3-yl)amino)pyridazin-3(2H)-one
Descriptor: 1,2-ETHANEDIOL, 4-chlorol-2-methyl-5-[[(3~{R})-1-methylpiperidin-3-yl]amino]pyridazin-3-one, Histone acetyltransferase KAT2B
Authors:Chung, C.-W.
Deposit date:2016-12-05
Release date:2017-12-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
J. Med. Chem., 60, 2017
5MLI
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N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(methylamino)pyridazin-3(2H)-one
Descriptor: 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one, Bromodomain-containing protein 4
Authors:Chung, C.-W.
Deposit date:2016-12-06
Release date:2017-12-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
J. Med. Chem., 60, 2017
9CR5
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BU of 9cr5 by Molmil
Crystal structure of GNAT superfamily acetyltransferase PA2271 from Pseudomonas aeruginosa
Descriptor: ACETYL COENZYME *A, Acetyltransferase PA2271, CHLORIDE ION, ...
Authors:Majorek, K.A, Cooper, D.R, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2024-07-20
Release date:2025-05-28
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural, functional, and regulatory evaluation of a cysteine post-translationally modified Gcn5-related N-acetyltransferase.
Biochem.Biophys.Res.Commun., 748, 2025
8GXF
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Pseudomonas flexibilis GCN5 family acetyltransferase
Descriptor: COENZYME A, GCN5 family acetyltransferase
Authors:Song, Y.J, Bao, R.
Deposit date:2022-09-20
Release date:2022-10-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:The novel type II toxin-antitoxin PacTA modulates Pseudomonas aeruginosa iron homeostasis by obstructing the DNA-binding activity of Fur.
Nucleic Acids Res., 50, 2022
9EVQ
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BU of 9evq by Molmil
Crystal structure of the kinetoplastid kinetochore protein KKT23 acetyltransferase domain from Trypanosoma brucei
Descriptor: ACETYL COENZYME *A, N-acetyltransferase domain-containing protein
Authors:Ludzia, P, Ishii, M, Akiyoshi, B.
Deposit date:2024-04-01
Release date:2024-08-28
Last modified:2025-01-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail.
Structure, 33, 2025
9EVR
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BU of 9evr by Molmil
Crystal structure of the kinetoplastid kinetochore protein KKT23 N-terminal domain from Trypanosoma brucei
Descriptor: N-acetyltransferase domain-containing protein
Authors:Ludzia, P, Ishii, M, Akiyoshi, B.
Deposit date:2024-04-01
Release date:2024-08-28
Last modified:2025-01-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail.
Structure, 33, 2025
9F5Q
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BU of 9f5q by Molmil
Crystal structure of selenomethionine-labelled kinetoplastid kinetochore protein KKT23 acetyltransferase domain from Trypanosoma brucei
Descriptor: ACETYL COENZYME *A, N-acetyltransferase domain-containing protein
Authors:Ludzia, P, Ishii, M, Akiyoshi, B.
Deposit date:2024-04-30
Release date:2024-08-28
Last modified:2025-01-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The kinetoplastid kinetochore protein KKT23 acetyltransferase is a structural homolog of GCN5 that acetylates the histone H2A C-terminal tail.
Structure, 33, 2025
1BOB
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BU of 1bob by Molmil
HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A
Descriptor: ACETYL COENZYME *A, CALCIUM ION, HISTONE ACETYLTRANSFERASE
Authors:Dutnall, R.N, Tafrov, S.T, Sternglanz, R, Ramakrishnan, V.
Deposit date:1998-07-02
Release date:1999-04-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily.
Cell(Cambridge,Mass.), 94, 1998
1Q2Y
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Crystal structure of the protein YJCF from Bacillus subtilis: a member of the GCN5-related N-acetyltransferase superfamily fold
Descriptor: similar to hypothetical proteins
Authors:Fedorov, A.A, Ramagopal, U.A, Fedorov, E.V, Thirumuruhan, R, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-07-27
Release date:2003-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the protein YJCF from Bacillus subtilis: a member of the GCN5-related N-acetyltransferase superfamily
To be Published
2R0Y
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BU of 2r0y by Molmil
Structure of the Rsc4 tandem bromodomain in complex with an acetylated H3 peptide
Descriptor: Chromatin structure-remodeling complex protein RSC4, Histone H3 peptide
Authors:VanDemark, A.P, Kasten, M.M, Ferris, E, Heroux, A, Hill, C.P, Cairns, B.R.
Deposit date:2007-08-21
Release date:2007-10-30
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.
Mol.Cell, 27, 2007
2R0V
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BU of 2r0v by Molmil
Structure of the Rsc4 tandem bromodomain acetylated at K25
Descriptor: Chromatin structure-remodeling complex protein RSC4, SULFATE ION
Authors:VanDemark, A.P, Kasten, M.M, Ferris, E, Heroux, A, Hill, C.P, Cairns, B.R.
Deposit date:2007-08-21
Release date:2007-10-30
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.
Mol.Cell, 27, 2007
2R10
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BU of 2r10 by Molmil
Structure of an acetylated Rsc4 tandem bromodomain Histone Chimera
Descriptor: 1,2-ETHANEDIOL, Chromatin structure-remodeling complex protein RSC4, LINKER, ...
Authors:VanDemark, A.P, Kasten, M.M, Ferris, E, Heroux, A, Hill, C.P, Cairns, B.R.
Deposit date:2007-08-21
Release date:2007-10-30
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.
Mol.Cell, 27, 2007
2R0S
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BU of 2r0s by Molmil
Crystal Structure of the Rsc4 tandem bromodomain
Descriptor: Chromatin structure-remodeling complex protein RSC4
Authors:VanDemark, A.P, Kasten, M.M, Ferris, E, Heroux, A, Hill, C.P, Cairns, B.R.
Deposit date:2007-08-21
Release date:2007-10-30
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.
Mol.Cell, 27, 2007
4MBU
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BU of 4mbu by Molmil
Crystal structure of N-acetyltransferase from Staphylococcus aureus Mu50
Descriptor: CADMIUM ION, PHOSPHATE ION, Similar to N-acetyltransferase
Authors:Srivastava, P, Khandokar, Y, Forwood, J.K.
Deposit date:2013-08-19
Release date:2014-09-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural characterization of a Gcn5-related N-acetyltransferase from Staphylococcus aureus.
Plos One, 9, 2014
1QSM
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Histone Acetyltransferase HPA2 from Saccharomyces Cerevisiae in Complex with Acetyl Coenzyme A
Descriptor: ACETYL COENZYME *A, HPA2 HISTONE ACETYLTRANSFERASE
Authors:Angus-Hill, M.L, Dutnall, R.N, Tafrov, S.T, Sternglanz, R, Ramakrishnan, V.
Deposit date:1999-06-22
Release date:1999-12-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily.
J.Mol.Biol., 294, 1999
1QSO
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BU of 1qso by Molmil
Histone Acetyltransferase HPA2 from Saccharomyces Cerevisiae
Descriptor: HPA2 HISTONE ACETYLTRANSFERASE
Authors:Angus-Hill, M.L, Dutnall, R.N, Tafrov, S.T, Sterngalnz, R, Ramakrishnan, V.
Deposit date:1999-06-22
Release date:1999-12-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily.
J.Mol.Biol., 294, 1999
4KLV
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BU of 4klv by Molmil
Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with 4-methylumbelliferyl phosphate
Descriptor: 1,2-ETHANEDIOL, 4-methylumbelliferyl phosphate, SULFATE ION, ...
Authors:Majorek, K.A, Chruszcz, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-07
Release date:2013-05-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
4KOT
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Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with Cefotaxime
Descriptor: (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Majorek, K.A, Chruszcz, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-12
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
4KOX
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Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with Cefalotin
Descriptor: 1,2-ETHANEDIOL, CEPHALOTHIN, SULFATE ION, ...
Authors:Majorek, K.A, Chruszcz, M, Zimmerman, M.D, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-12
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
4KOR
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Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with 7-aminocephalosporanic acid
Descriptor: 1,2-ETHANEDIOL, 7-aminocephalosporanic acid, SULFATE ION, ...
Authors:Majorek, K.A, Porebski, P.J, Chruszcz, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-12
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
4KOV
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Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with Cefuroxime
Descriptor: (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Majorek, K.A, Chruszcz, M, Otwinowski, Z, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-12
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
4KOS
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Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with Cefmetazole
Descriptor: (6R,7S)-7-({[(cyanomethyl)sulfanyl]acetyl}amino)-7-methoxy-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia -1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1,2-ETHANEDIOL, SULFATE ION, ...
Authors:Majorek, K.A, Chruszcz, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-12
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
4KOW
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Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with Cefoxitin
Descriptor: 1,2-ETHANEDIOL, CEFOXITIN, SULFATE ION, ...
Authors:Majorek, K.A, Porebski, P.J, Chruszcz, M, Grabowski, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-12
Release date:2013-06-05
Last modified:2025-04-02
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013
4KOY
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Crystal structure of a GNAT superfamily acetyltransferase PA4794 in complex with Cephalosporin C
Descriptor: 1,2-ETHANEDIOL, 4-(3-ACETOXYMETHYL-2-CARBOXY-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-EN-7-YLCARBAMOYL)-1-CARBOXY-BUTYL-AMMONIUM, SULFATE ION, ...
Authors:Majorek, K.A, Porebski, P.J, Chruszcz, M, Cymborowski, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG)
Deposit date:2013-05-12
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural, Functional, and Inhibition Studies of a Gcn5-related N-Acetyltransferase (GNAT) Superfamily Protein PA4794: A NEW C-TERMINAL LYSINE PROTEIN ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 288, 2013

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