5EKU
| |
5IC5
| Bacteriophytochrome response regulator RtBRR | Descriptor: | CACODYLATE ION, Candidate response regulator, CheY, ... | Authors: | Baker, A.W, Satyshur, K.A, Forest, K.T. | Deposit date: | 2016-02-22 | Release date: | 2016-03-02 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Arm-in-Arm Response Regulator Dimers Promote Intermolecular Signal Transduction. J.Bacteriol., 198, 2016
|
|
5KLH
| |
5KMX
| Structure of Trypanosoma congolense Insect Stage Antigen | Descriptor: | GLYCEROL, Putative uncharacterized protein TCIL3000_10_9440, SULFATE ION | Authors: | Ramaswamy, R, Parker, M.L, Boulanger, M.J. | Deposit date: | 2016-06-27 | Release date: | 2017-07-05 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.452 Å) | Cite: | Structural characterization reveals a novel bilobed architecture for the ectodomains of insect stage expressed Trypanosoma brucei PSSA-2 and Trypanosoma congolense ISA. Protein Sci., 25, 2016
|
|
6DNZ
| Trypanosoma brucei PRMT1 enzyme-prozyme heterotetrameric complex with AdoHcy | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Arginine N-methyltransferase, putative, ... | Authors: | Hashimoto, H, Kafkova, L, Jordan, K, Read, L.K, Debler, E.W. | Deposit date: | 2018-06-08 | Release date: | 2019-06-12 | Last modified: | 2020-02-12 | Method: | X-RAY DIFFRACTION (2.384 Å) | Cite: | Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme). J.Mol.Biol., 432, 2020
|
|
2YHU
| Trypanosoma brucei PTR1 in complex with inhibitor WHF30 | Descriptor: | 3-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1-THIOPHEN-2-YLPROPAN-1-ONE, ACETATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P. | Deposit date: | 2011-05-06 | Release date: | 2012-05-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
|
|
1APJ
| NMR STUDY OF THE TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-LIKE DOMAIN (TB MODULE/8-CYS DOMAIN), NMR, 21 STRUCTURES | Descriptor: | FIBRILLIN | Authors: | Yuan, X, Downing, A.K, Knott, V, Handford, P.A. | Deposit date: | 1997-07-22 | Release date: | 1998-01-28 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Solution structure of the transforming growth factor beta-binding protein-like module, a domain associated with matrix fibrils. EMBO J., 16, 1997
|
|
6RXC
| Leishmania major pteridine reductase 1 (LmPTR1) in complex with inhibitor 4 (NMT-C0026) | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Pteridine reductase 1, methyl 1-[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-(3-oxidanylpropyl)amino]phenyl]carbonylpiperidine-4-carboxylate | Authors: | Di Pisa, F, Dello Iacono, L, Pozzi, C, Mangani, S. | Deposit date: | 2019-06-07 | Release date: | 2020-07-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J.Med.Chem., 65, 2022
|
|
5AON
| Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei | Descriptor: | PEROXIN 14, SULFATE ION | Authors: | Obita, T, Sugawara, Y, Mizuguchi, M, Watanabe, Y, Kawaguchi, K, Imanaka, T. | Deposit date: | 2015-09-11 | Release date: | 2015-12-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.646 Å) | Cite: | Characterization of the Interaction between Trypanosoma Brucei Pex5P and its Receptor Pex14P. FEBS Lett., 590, 2016
|
|
6ITO
| Crystal structure of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, AMP and inhibitor Ribose 5-Phosphate | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, OXALATE ION, ... | Authors: | Zhong, W, Cai, Q, El Sahili, A, Mu, Y, Lescar, J, Dedon, P.C. | Deposit date: | 2018-11-24 | Release date: | 2019-08-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis. J.Mol.Biol., 431, 2019
|
|
1Y98
| Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide. | Descriptor: | Breast cancer type 1 susceptibility protein, COBALT (II) ION, CtIP PHOSPHORYLATED PEPTIDE, ... | Authors: | Varma, A.K, Brown, R.S, Birrane, G, Ladias, J.A.A. | Deposit date: | 2004-12-14 | Release date: | 2005-08-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex. Biochemistry, 44, 2005
|
|
5H9K
| |
2BKA
| CC3(TIP30)Crystal Structure | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | El Omari, K, Bird, L.E, Nichols, C.E, Ren, J, Stammers, D.K. | Deposit date: | 2005-02-14 | Release date: | 2005-02-21 | Last modified: | 2016-12-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of Cc3 (Tip30): Implications for its Role as a Tumor Suppressor J.Biol.Chem., 280, 2005
|
|
3E4O
| Crystal structure of succinate bound state DctB | Descriptor: | C4-dicarboxylate transport sensor protein dctB, MAGNESIUM ION, SUCCINIC ACID | Authors: | Zhou, Y.F, Nan, J, Nan, B.Y, Liang, Y.H, Panjikar, S, Su, X.D. | Deposit date: | 2008-08-12 | Release date: | 2008-10-21 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain. J.Mol.Biol., 383, 2008
|
|
3VOM
| Structure of a putative phosphoserine aminotransferase from mycobacterium tuberculosis | Descriptor: | GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, Putative phosphoserine aminotransferase, ... | Authors: | Coulibaly, F, Lassalle, E, Baker, H.M, Baker, E.N. | Deposit date: | 2012-01-30 | Release date: | 2012-02-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 68, 2012
|
|
3E4P
| Crystal structure of malonate occupied DctB | Descriptor: | C4-dicarboxylate transport sensor protein dctB, MALONIC ACID, STRONTIUM ION | Authors: | Zhou, Y.F, Nan, J, Nan, B.Y, Liang, Y.H, Panjikar, S, Su, X.D. | Deposit date: | 2008-08-12 | Release date: | 2008-10-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain. J.Mol.Biol., 383, 2008
|
|
2FYF
| Structure of a putative phosphoserine aminotransferase from Mycobacterium Tuberculosis | Descriptor: | GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, ... | Authors: | Coulibaly, F, Lassalle, E, Baker, E.N, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) | Deposit date: | 2006-02-07 | Release date: | 2007-01-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis. Acta Crystallogr.,Sect.D, 68, 2012
|
|
3E4Q
| Crystal structure of apo DctB | Descriptor: | C4-dicarboxylate transport sensor protein dctB, CALCIUM ION | Authors: | Zhou, Y.F, Nan, J, Nan, B.Y, Liang, Y.H, Panjikar, S, Su, X.D. | Deposit date: | 2008-08-12 | Release date: | 2008-10-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain. J.Mol.Biol., 383, 2008
|
|
2VZ0
| Pteridine Reductase 1 (PTR1) from Trypanosoma Brucei in complex with NADP and DDD00066641 | Descriptor: | 6-(4-methylphenyl)quinazoline-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | Authors: | Robinson, D.A, Thompson, S, Sienkiewicz, N, Fairlamb, A.H. | Deposit date: | 2008-07-29 | Release date: | 2009-09-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Development and Validation of a Cytochrome C Coupled Assay for Pteridine Reductase 1 and Dihydrofolate Reductase. Anal.Biochem., 396, 2010
|
|
2YHI
| Trypanosoma brucei PTR1 in complex with inhibitor WH16 | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | Authors: | Nerini, E, Dawson, A, Hunter, W.N, Costi, M.P. | Deposit date: | 2011-05-03 | Release date: | 2012-05-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. ACS Omega, 2, 2017
|
|
2WD8
| PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00071204 | Descriptor: | 1-(3,4-DICHLOROBENZYL)-7-PHENYL-1H-BENZIMIDAZOL-2-AMINE, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R. | Deposit date: | 2009-03-20 | Release date: | 2009-06-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J.Med.Chem., 52, 2009
|
|
2WD7
| PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00066750 | Descriptor: | 6-chloro-1H-benzimidazol-2-amine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | Authors: | Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R. | Deposit date: | 2009-03-20 | Release date: | 2009-06-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J.Med.Chem., 52, 2009
|
|
9F8W
| |
3UAQ
| Crystal Structure of the N-lobe Domain of Lactoferrin Binding Protein B (LbpB) of Moraxella bovis | Descriptor: | LbpB B-lobe | Authors: | Arutyunova, E, Brooks, C.L, Beddeck, A, Mak, M.W, Schryvers, A.B, Lemieux, M.J. | Deposit date: | 2011-10-21 | Release date: | 2012-03-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9318 Å) | Cite: | Crystal structure of the N-lobe of lactoferrin binding protein B from Moraxella bovis(1). Biochem.Cell Biol., 90, 2012
|
|
6CPJ
| Solution structure of SH3 domain from Shank2 | Descriptor: | SH3 and multiple ankyrin repeat domains protein 2 | Authors: | Ishida, H, Vogel, H.J. | Deposit date: | 2018-03-13 | Release date: | 2018-08-15 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels. FEBS Lett., 592, 2018
|
|