7MNJ
| Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 145-673) | Descriptor: | E3 SUMO-protein ligase RanBP2 | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Patke, A, Dasso, M, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-05-01 | Release date: | 2022-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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4V2N
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8S9T
| CRISPR-Cas type III-D effector complex | Descriptor: | CRISPR RNA, Cas10, Cas7-2x, ... | Authors: | Schwartz, E.A, Taylor, D.W. | Deposit date: | 2023-03-30 | Release date: | 2024-04-24 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | RNA targeting and cleavage by the type III-Dv CRISPR effector complex. Nat Commun, 15, 2024
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8S9U
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6WTP
| Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 3 | Descriptor: | GLYCEROL, Tyrosine-protein kinase JAK2, tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Authors: | Yu, S, Nithianantham, S, Fischer, M. | Deposit date: | 2020-05-03 | Release date: | 2021-05-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood, 138, 2021
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4V0K
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8SUO
| BA.2/AZD1061/AZD3152 structure analysis | Descriptor: | AZD1061 heavy chain, AZD1061 light chain, AZD3152 heavy chain, ... | Authors: | Oganesyan, V, van Dyk, N, Dippel, A, Barnes, A, O'Connor, E. | Deposit date: | 2023-05-12 | Release date: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | X-ray crystal structure of BA.2 RBD bound by two neutralizing antibodies To Be Published
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8SVP
| Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-278 | Descriptor: | (1P)-N-(5-tert-butyl-2-{[(3R)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide | Authors: | Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. | Deposit date: | 2023-05-17 | Release date: | 2024-05-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
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8SL9
| Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73 | Descriptor: | 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[(2R,4R)-1-{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}-2-carboxypiperidin-4-yl]-5'-thioadenosine, ... | Authors: | Shaw, G.X, Shi, G, Cherry, S, Needle, D, Tropea, J.E, Waugh, D.S, Ji, X. | Deposit date: | 2023-04-21 | Release date: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of Francisella tularensis HPPK-DHPS in complex with HPPK inhibitor HP-73 To be published
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8SVR
| Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-326 | Descriptor: | (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-5-methyl-1-(2,4,5-trimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide | Authors: | Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. | Deposit date: | 2023-05-17 | Release date: | 2024-05-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
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8SVQ
| Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-312 | Descriptor: | (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide | Authors: | Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. | Deposit date: | 2023-05-17 | Release date: | 2024-05-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
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8SFX
| High Affinity nanobodies against GFP | Descriptor: | D-MALATE, GLYCEROL, Green fluorescent protein, ... | Authors: | Ketaren, N.E, Rout, M.P, Bonanno, J.B, Almo, S.C. | Deposit date: | 2023-04-11 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | High Affinity nanobodies against GFP To Be Published
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6X3A
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8ST6
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8SVO
| Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-310 | Descriptor: | (1P)-N-(5-tert-butyl-2-{[(2S)-pentan-2-yl]oxy}phenyl)-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide | Authors: | Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. | Deposit date: | 2023-05-17 | Release date: | 2024-05-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
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6X39
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6X38
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8SFV
| High affinity nanobodies to GFP | Descriptor: | GLYCEROL, Green fluorescent protein, LaG19, ... | Authors: | Ketaren, N.E, Rout, M.P, Bonanno, J.B, Almo, S.C. | Deposit date: | 2023-04-11 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | High affinity nanobodies to GFP To Be Published
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8SV2
| Pasteurella multocida alpha2,3/2,6 sialyltransferase D141N bound to CMP | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-2,3/2,6-sialyltransferase/sialidase, CYTIDINE-5'-MONOPHOSPHATE, ... | Authors: | Stubbs, H.E, Iverson, T.M. | Deposit date: | 2023-05-15 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Pasteurella multocida alpha2,3/2,6 sialyltransferase D141N bound to CMP To Be Published
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8SFS
| High Affinity nanobodies against GFP | Descriptor: | AMMONIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Ketaren, N.E, Rout, M.P, Bonnano, J.B, Almo, S.C. | Deposit date: | 2023-04-11 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | High Affinity nanobodies against GFP To Be Published
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8SFZ
| High Affinity nanobodies against GFP | Descriptor: | Green fluorescent protein, LaG35, POTASSIUM ION, ... | Authors: | Ketaren, N.E, Rout, M.P, Bonanno, J.B, Almo, S.C. | Deposit date: | 2023-04-11 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | High Affinity nanobodies against GFP To Be Published
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8SLC
| High Affinity nanobodies against GFP | Descriptor: | CHLORIDE ION, GLYCEROL, Green fluorescent protein, ... | Authors: | Ketaren, N.E, Rout, M.P, Bonanno, J.B, Almo, S.C. | Deposit date: | 2023-04-21 | Release date: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | High Affinity nanobodies against GFP To Be Published
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8SON
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4W7Z
| Tetrameric BAP29 vDED without disulfide bonds | Descriptor: | ACETATE ION, B-cell receptor-associated protein 29, SULFATE ION | Authors: | Quistgaard, E.M. | Deposit date: | 2014-08-22 | Release date: | 2014-10-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A disulfide polymerized protein crystal. Chem.Commun.(Camb.), 50, 2014
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4W8C
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